Details for: MAOB
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 43.5904
Cell Significance Index: -20.5800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.5447
Cell Significance Index: -22.8900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.2508
Cell Significance Index: -20.7200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.7106
Cell Significance Index: 45.6600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.7217
Cell Significance Index: 115.7700 - Cell Name: theca cell (CL0000503)
Fold Change: 1.6817
Cell Significance Index: 9.8800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.6708
Cell Significance Index: 63.2700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.6189
Cell Significance Index: 43.3800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.4801
Cell Significance Index: 65.4700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.4577
Cell Significance Index: 111.8600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4004
Cell Significance Index: 277.9100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.2343
Cell Significance Index: 169.5000 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 1.1507
Cell Significance Index: 14.4900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1040
Cell Significance Index: 66.2800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9737
Cell Significance Index: 28.0600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9420
Cell Significance Index: 93.1900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.8582
Cell Significance Index: 12.0000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7789
Cell Significance Index: 84.7300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7588
Cell Significance Index: 152.2100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.6546
Cell Significance Index: 95.1600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.6006
Cell Significance Index: 14.6600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5412
Cell Significance Index: 88.0300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.5347
Cell Significance Index: 15.2600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4848
Cell Significance Index: 92.2700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4786
Cell Significance Index: 33.1000 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.4285
Cell Significance Index: 6.6300 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3968
Cell Significance Index: 10.4400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3325
Cell Significance Index: 119.2500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3186
Cell Significance Index: 220.3900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2940
Cell Significance Index: 6.3700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.2229
Cell Significance Index: 3.2900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1612
Cell Significance Index: 4.0300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1057
Cell Significance Index: 1.5600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0498
Cell Significance Index: 1.0600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0376
Cell Significance Index: 70.7500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0326
Cell Significance Index: 17.8000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0257
Cell Significance Index: 16.3500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0092
Cell Significance Index: 4.0500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.0051
Cell Significance Index: 0.1500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0003
Cell Significance Index: -0.5400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0008
Cell Significance Index: -0.5500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0014
Cell Significance Index: -0.0500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0026
Cell Significance Index: -0.3000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0035
Cell Significance Index: -0.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0053
Cell Significance Index: -3.9200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0081
Cell Significance Index: -5.0300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0117
Cell Significance Index: -18.0500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0191
Cell Significance Index: -10.7600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0200
Cell Significance Index: -27.2600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0305
Cell Significance Index: -23.1100 - Cell Name: peg cell (CL4033014)
Fold Change: -0.0377
Cell Significance Index: -0.8700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0402
Cell Significance Index: -18.2600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0500
Cell Significance Index: -1.6000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0511
Cell Significance Index: -8.7200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0584
Cell Significance Index: -12.3100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0596
Cell Significance Index: -17.1600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0754
Cell Significance Index: -8.7900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0783
Cell Significance Index: -14.1200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0785
Cell Significance Index: -3.6600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0992
Cell Significance Index: -10.1300 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.1057
Cell Significance Index: -1.7100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1266
Cell Significance Index: -16.3500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1483
Cell Significance Index: -18.2300 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: -0.1487
Cell Significance Index: -0.5600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1723
Cell Significance Index: -19.6700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1828
Cell Significance Index: -14.4800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1862
Cell Significance Index: -19.3900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1917
Cell Significance Index: -24.5800 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.1960
Cell Significance Index: -2.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1987
Cell Significance Index: -23.4300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1997
Cell Significance Index: -14.8800 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.2080
Cell Significance Index: -1.5900 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2131
Cell Significance Index: -3.6900 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.2155
Cell Significance Index: -2.8800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2319
Cell Significance Index: -7.3900 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2502
Cell Significance Index: -2.5900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2584
Cell Significance Index: -15.8800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2694
Cell Significance Index: -8.8200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2809
Cell Significance Index: -17.2200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2834
Cell Significance Index: -4.2700 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.2842
Cell Significance Index: -4.7800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3116
Cell Significance Index: -22.0400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3147
Cell Significance Index: -16.3900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3328
Cell Significance Index: -11.6600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.3487
Cell Significance Index: -16.3900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3761
Cell Significance Index: -10.5100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3773
Cell Significance Index: -23.7800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3819
Cell Significance Index: -21.4300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3836
Cell Significance Index: -20.1400 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.3930
Cell Significance Index: -5.0400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4387
Cell Significance Index: -22.7900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4418
Cell Significance Index: -11.0200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4443
Cell Significance Index: -8.9200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4536
Cell Significance Index: -11.6600 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5184
Cell Significance Index: -11.2000 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.5345
Cell Significance Index: -13.3300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5399
Cell Significance Index: -19.8200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5617
Cell Significance Index: -12.3000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.5788
Cell Significance Index: -14.0200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6018
Cell Significance Index: -10.3100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 486124066
Symbol: AOFB_HUMAN
Name: Monoamine oxidase type B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2023912
Title: Human monoamine oxidase A and B genes exhibit identical exon-intron organization.
PubMed ID: 2023912
PubMed ID: 3387449
Title: cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.
PubMed ID: 3387449
PubMed ID: 8515265
Title: The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical.
PubMed ID: 8515265
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 1432104
Title: Promoter organization and activity of human monoamine oxidase (MAO) A and B genes.
PubMed ID: 1432104
PubMed ID: 11049757
Title: High-level expression of human liver monoamine oxidase B in Pichia pastoris.
PubMed ID: 11049757
PubMed ID: 8665924
Title: Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis.
PubMed ID: 8665924
PubMed ID: 20493079
Title: The oxidation of adrenaline and noradrenaline by the two forms of monoamine oxidase from human and rat brain.
PubMed ID: 20493079
PubMed ID: 8316221
Title: Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines.
PubMed ID: 8316221
PubMed ID: 11134050
Title: Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid.
PubMed ID: 11134050
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 11753429
Title: Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders.
PubMed ID: 11753429
DOI: 10.1038/nsb732
PubMed ID: 12913124
Title: Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures.
PubMed ID: 12913124
PubMed ID: 15027868
Title: Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class.
PubMed ID: 15027868
DOI: 10.1021/jm031087c
PubMed ID: 15710600
Title: Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.
PubMed ID: 15710600
PubMed ID: 16366596
Title: Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis.
PubMed ID: 16366596
DOI: 10.1021/jm0506266
Sequence Information:
- Length: 520
- Mass: 58763
- Checksum: 358D1025F5BCA604
- Sequence:
MSNKCDVVVV GGGISGMAAA KLLHDSGLNV VVLEARDRVG GRTYTLRNQK VKYVDLGGSY VGPTQNRILR LAKELGLETY KVNEVERLIH HVKGKSYPFR GPFPPVWNPI TYLDHNNFWR TMDDMGREIP SDAPWKAPLA EEWDNMTMKE LLDKLCWTES AKQLATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS TTNGGQERKF VGGSGQVSER IMDLLGDRVK LERPVIYIDQ TRENVLVETL NHEMYEAKYV ISAIPPTLGM KIHFNPPLPM MRNQMITRVP LGSVIKCIVY YKEPFWRKKD YCGTMIIDGE EAPVAYTLDD TKPEGNYAAI MGFILAHKAR KLARLTKEER LKKLCELYAK VLGSLEALEP VHYEEKNWCE EQYSGGCYTT YFPPGILTQY GRVLRQPVDR IYFAGTETAT HWSGYMEGAV EAGERAAREI LHAMGKIPED EIWQSEPESV DVPAQPITTT FLERHLPSVP GLLRLIGLTT IFSATALGFL AHKRGLLVRV
Genular Protein ID: 2197264434
Symbol: B7Z242_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 504
- Mass: 57259
- Checksum: EFC8CAD6587C5D76
- Sequence:
MAAAKLLHDS GLNVVVLEAR DRVGGRTYTL RNQKVKYVDL GGSYVGPTQN RILRLAKELG LETYKVNEVE RLIHHVKGKS YPFRGPFPPV WNPITYLDHN NFWRTMDDMG REIPSDAPWK APLAEEWDNM TMKELLDKLC WTESAKQLAT LFVNLCVTAE THEVSALWFL WYVKQCGGTT RIISTTNGGQ ERKFVGGSGQ VSERIMDLLG DRVKLERPVI YIDQTRENVL VETLNHEMYE AKYVISAIPP TLGMKIHFNP PLPMMRNQMI TRVPLGSVIK CIVYYKEPFW RKKDYCGTMI IDGEEAPVAY TLDDTKPEGN YAAIMGFILA HKARKLARLT KEERLKKLCE LYAKVLGSLE ALEPVHYEEK NWCEEQYSGG CYTTYFPPGI LTQYGRVLRQ PVDRIYFAGT ETATHWSGYM EGAVEAGERA AREILHAMGK IPEDEIWQSE PESVDVPAQP ITTTFLERHL PSVPGLLRLI GLTTIFSATA LGFLAHKRGL LVRV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.