Details for: MAOB

Gene ID: 4129

Symbol: MAOB

Ensembl ID: ENSG00000069535

Description: monoamine oxidase B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 43.5904
    Cell Significance Index: -20.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5447
    Cell Significance Index: -22.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2508
    Cell Significance Index: -20.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.7106
    Cell Significance Index: 45.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7217
    Cell Significance Index: 115.7700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.6817
    Cell Significance Index: 9.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6708
    Cell Significance Index: 63.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6189
    Cell Significance Index: 43.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4801
    Cell Significance Index: 65.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4577
    Cell Significance Index: 111.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4004
    Cell Significance Index: 277.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2343
    Cell Significance Index: 169.5000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.1507
    Cell Significance Index: 14.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1040
    Cell Significance Index: 66.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9737
    Cell Significance Index: 28.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9420
    Cell Significance Index: 93.1900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.8582
    Cell Significance Index: 12.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7789
    Cell Significance Index: 84.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7588
    Cell Significance Index: 152.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.6546
    Cell Significance Index: 95.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6006
    Cell Significance Index: 14.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5412
    Cell Significance Index: 88.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5347
    Cell Significance Index: 15.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4848
    Cell Significance Index: 92.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4786
    Cell Significance Index: 33.1000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4285
    Cell Significance Index: 6.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3968
    Cell Significance Index: 10.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3325
    Cell Significance Index: 119.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3186
    Cell Significance Index: 220.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2940
    Cell Significance Index: 6.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2229
    Cell Significance Index: 3.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1612
    Cell Significance Index: 4.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1057
    Cell Significance Index: 1.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0498
    Cell Significance Index: 1.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0376
    Cell Significance Index: 70.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0326
    Cell Significance Index: 17.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0257
    Cell Significance Index: 16.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0092
    Cell Significance Index: 4.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0051
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0008
    Cell Significance Index: -0.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0026
    Cell Significance Index: -0.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0035
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0081
    Cell Significance Index: -5.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0117
    Cell Significance Index: -18.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0191
    Cell Significance Index: -10.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0200
    Cell Significance Index: -27.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0305
    Cell Significance Index: -23.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0377
    Cell Significance Index: -0.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0402
    Cell Significance Index: -18.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0500
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0511
    Cell Significance Index: -8.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0584
    Cell Significance Index: -12.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0596
    Cell Significance Index: -17.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0754
    Cell Significance Index: -8.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0783
    Cell Significance Index: -14.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0785
    Cell Significance Index: -3.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0992
    Cell Significance Index: -10.1300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1057
    Cell Significance Index: -1.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1266
    Cell Significance Index: -16.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1483
    Cell Significance Index: -18.2300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.1487
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1723
    Cell Significance Index: -19.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1828
    Cell Significance Index: -14.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1862
    Cell Significance Index: -19.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1917
    Cell Significance Index: -24.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1960
    Cell Significance Index: -2.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1987
    Cell Significance Index: -23.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1997
    Cell Significance Index: -14.8800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2080
    Cell Significance Index: -1.5900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2131
    Cell Significance Index: -3.6900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2155
    Cell Significance Index: -2.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2319
    Cell Significance Index: -7.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2502
    Cell Significance Index: -2.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2584
    Cell Significance Index: -15.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2694
    Cell Significance Index: -8.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2809
    Cell Significance Index: -17.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2834
    Cell Significance Index: -4.2700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2842
    Cell Significance Index: -4.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3116
    Cell Significance Index: -22.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3147
    Cell Significance Index: -16.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3328
    Cell Significance Index: -11.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3487
    Cell Significance Index: -16.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3761
    Cell Significance Index: -10.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3773
    Cell Significance Index: -23.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3819
    Cell Significance Index: -21.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3836
    Cell Significance Index: -20.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3930
    Cell Significance Index: -5.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4387
    Cell Significance Index: -22.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4418
    Cell Significance Index: -11.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4443
    Cell Significance Index: -8.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4536
    Cell Significance Index: -11.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5184
    Cell Significance Index: -11.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5345
    Cell Significance Index: -13.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5399
    Cell Significance Index: -19.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5617
    Cell Significance Index: -12.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5788
    Cell Significance Index: -14.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6018
    Cell Significance Index: -10.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAOB is a flavin-containing enzyme that catalyzes the oxidative deamination of biogenic amines, resulting in the production of aldehydes and ammonia. The enzyme's activity is characterized by its ability to bind to FAD (flavin adenine dinucleotide) and serve as a cofactor for the reaction. MAOB has a high Km (Michaelis constant) for its substrates, indicating its ability to efficiently metabolize biogenic amines at low concentrations. The enzyme's kinetic properties and substrate specificity are critical for its role in regulating neurotransmitter levels and modulating various physiological processes. **Pathways and Functions** MAOB is involved in several key pathways, including: 1. **Dopamine catabolic process**: MAOB is responsible for the breakdown of dopamine, a key neurotransmitter involved in motor control, reward, and motivation. 2. **Biogenic amine metabolism**: MAOB is a key enzyme in the oxidative deamination of biogenic amines, resulting in the production of aldehydes and ammonia. 3. **Electron transport chain**: MAOB is thought to be involved in the electron transport chain, where it contributes to the generation of ATP (adenosine triphosphate) in mitochondria. 4. **Neurotransmitter regulation**: MAOB's activity is critical for regulating the levels of biogenic amines in the brain, which in turn modulates various physiological processes, including mood, motivation, and motor control. **Clinical Significance** Dysregulation of MAOB has been implicated in various neurological and psychiatric disorders, including: 1. **Parkinson's disease**: MAOB deficiency has been linked to the development of Parkinson's disease, a neurodegenerative disorder characterized by motor dysfunction and dopamine depletion. 2. **Depression**: MAOB's activity has been shown to influence mood regulation, and alterations in MAOB expression or activity may contribute to the development of depression. 3. **Schizophrenia**: MAOB's role in regulating dopamine levels has also been implicated in the pathophysiology of schizophrenia, a psychiatric disorder characterized by cognitive and motor dysfunction. In conclusion, MAOB is a critical enzyme involved in the regulation of biogenic amine levels and neurotransmitter activity. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into the molecular mechanisms underlying these conditions.

Genular Protein ID: 486124066

Symbol: AOFB_HUMAN

Name: Monoamine oxidase type B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2023912

Title: Human monoamine oxidase A and B genes exhibit identical exon-intron organization.

PubMed ID: 2023912

DOI: 10.1073/pnas.88.9.3637

PubMed ID: 3387449

Title: cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties.

PubMed ID: 3387449

DOI: 10.1073/pnas.85.13.4934

PubMed ID: 8515265

Title: The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical.

PubMed ID: 8515265

DOI: 10.1111/j.1471-4159.1993.tb03554.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 1432104

Title: Promoter organization and activity of human monoamine oxidase (MAO) A and B genes.

PubMed ID: 1432104

DOI: 10.1523/jneurosci.12-11-04437.1992

PubMed ID: 11049757

Title: High-level expression of human liver monoamine oxidase B in Pichia pastoris.

PubMed ID: 11049757

DOI: 10.1006/prep.2000.1309

PubMed ID: 8665924

Title: Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis.

PubMed ID: 8665924

DOI: 10.1111/j.1432-1033.1996.00996.x

PubMed ID: 20493079

Title: The oxidation of adrenaline and noradrenaline by the two forms of monoamine oxidase from human and rat brain.

PubMed ID: 20493079

DOI: 10.1016/0197-0186(86)90182-8

PubMed ID: 8316221

Title: Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines.

PubMed ID: 8316221

PubMed ID: 11134050

Title: Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid.

PubMed ID: 11134050

DOI: 10.1074/jbc.m006972200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11753429

Title: Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders.

PubMed ID: 11753429

DOI: 10.1038/nsb732

PubMed ID: 12913124

Title: Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures.

PubMed ID: 12913124

DOI: 10.1073/pnas.1633804100

PubMed ID: 15027868

Title: Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class.

PubMed ID: 15027868

DOI: 10.1021/jm031087c

PubMed ID: 15710600

Title: Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.

PubMed ID: 15710600

DOI: 10.1074/jbc.m500949200

PubMed ID: 16366596

Title: Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis.

PubMed ID: 16366596

DOI: 10.1021/jm0506266

Sequence Information:

  • Length: 520
  • Mass: 58763
  • Checksum: 358D1025F5BCA604
  • Sequence:
  • MSNKCDVVVV GGGISGMAAA KLLHDSGLNV VVLEARDRVG GRTYTLRNQK VKYVDLGGSY 
    VGPTQNRILR LAKELGLETY KVNEVERLIH HVKGKSYPFR GPFPPVWNPI TYLDHNNFWR 
    TMDDMGREIP SDAPWKAPLA EEWDNMTMKE LLDKLCWTES AKQLATLFVN LCVTAETHEV 
    SALWFLWYVK QCGGTTRIIS TTNGGQERKF VGGSGQVSER IMDLLGDRVK LERPVIYIDQ 
    TRENVLVETL NHEMYEAKYV ISAIPPTLGM KIHFNPPLPM MRNQMITRVP LGSVIKCIVY 
    YKEPFWRKKD YCGTMIIDGE EAPVAYTLDD TKPEGNYAAI MGFILAHKAR KLARLTKEER 
    LKKLCELYAK VLGSLEALEP VHYEEKNWCE EQYSGGCYTT YFPPGILTQY GRVLRQPVDR 
    IYFAGTETAT HWSGYMEGAV EAGERAAREI LHAMGKIPED EIWQSEPESV DVPAQPITTT 
    FLERHLPSVP GLLRLIGLTT IFSATALGFL AHKRGLLVRV

Genular Protein ID: 2197264434

Symbol: B7Z242_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 504
  • Mass: 57259
  • Checksum: EFC8CAD6587C5D76
  • Sequence:
  • MAAAKLLHDS GLNVVVLEAR DRVGGRTYTL RNQKVKYVDL GGSYVGPTQN RILRLAKELG 
    LETYKVNEVE RLIHHVKGKS YPFRGPFPPV WNPITYLDHN NFWRTMDDMG REIPSDAPWK 
    APLAEEWDNM TMKELLDKLC WTESAKQLAT LFVNLCVTAE THEVSALWFL WYVKQCGGTT 
    RIISTTNGGQ ERKFVGGSGQ VSERIMDLLG DRVKLERPVI YIDQTRENVL VETLNHEMYE 
    AKYVISAIPP TLGMKIHFNP PLPMMRNQMI TRVPLGSVIK CIVYYKEPFW RKKDYCGTMI 
    IDGEEAPVAY TLDDTKPEGN YAAIMGFILA HKARKLARLT KEERLKKLCE LYAKVLGSLE 
    ALEPVHYEEK NWCEEQYSGG CYTTYFPPGI LTQYGRVLRQ PVDRIYFAGT ETATHWSGYM 
    EGAVEAGERA AREILHAMGK IPEDEIWQSE PESVDVPAQP ITTTFLERHL PSVPGLLRLI 
    GLTTIFSATA LGFLAHKRGL LVRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.