Details for: MEIS1

Gene ID: 4211

Symbol: MEIS1

Ensembl ID: ENSG00000143995

Description: Meis homeobox 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.51
    Marker Score: 28,918
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.17
    Marker Score: 31,478
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.1
    Marker Score: 21,999
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.07
    Marker Score: 5,731
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.07
    Marker Score: 72,295
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.89
    Marker Score: 2,927
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.75
    Marker Score: 2,088
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.6
    Marker Score: 12,055
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.57
    Marker Score: 6,870
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.39
    Marker Score: 7,788
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.34
    Marker Score: 1,939
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 3.23
    Marker Score: 1,810
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 3.14
    Marker Score: 917
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.09
    Marker Score: 12,947
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.86
    Marker Score: 743
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.66
    Marker Score: 3,010
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.55
    Marker Score: 806
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.46
    Marker Score: 55,070
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.41
    Marker Score: 1,156
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.38
    Marker Score: 2,272
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.1
    Marker Score: 2,325
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2
    Marker Score: 1,036
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.93
    Marker Score: 25,409
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.76
    Marker Score: 1,977
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.75
    Marker Score: 60,531
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.73
    Marker Score: 582
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.73
    Marker Score: 7,445
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.71
    Marker Score: 436
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.7
    Marker Score: 580
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.69
    Marker Score: 19,074
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.61
    Marker Score: 673
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.59
    Marker Score: 1,105
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.58
    Marker Score: 3,727
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.51
    Marker Score: 2,563
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.51
    Marker Score: 15,263
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.49
    Marker Score: 5,313
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.45
    Marker Score: 1,506
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.42
    Marker Score: 1,776
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.42
    Marker Score: 388
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.41
    Marker Score: 30,175
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.38
    Marker Score: 3,306
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.33
    Marker Score: 790
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.32
    Marker Score: 2,758
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.32
    Marker Score: 435
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.28
    Marker Score: 368
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19,947
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.25
    Marker Score: 472
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2
    Marker Score: 2,737
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.17
    Marker Score: 1,233
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.17
    Marker Score: 546
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.16
    Marker Score: 1,242
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.15
    Marker Score: 1,021
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,772
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.13
    Marker Score: 613
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.12
    Marker Score: 453
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.12
    Marker Score: 1,349
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.12
    Marker Score: 747
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.11
    Marker Score: 914
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1
    Marker Score: 328
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.09
    Marker Score: 1,679
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.09
    Marker Score: 2,852
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.09
    Marker Score: 1,153
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.05
    Marker Score: 6,843
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.04
    Marker Score: 326
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,744
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.02
    Marker Score: 352
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1
    Marker Score: 704
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,764
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,989
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.98
    Marker Score: 1,278
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2,299
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.96
    Marker Score: 654
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.96
    Marker Score: 361
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.94
    Marker Score: 3,651
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.94
    Marker Score: 232
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.94
    Marker Score: 1,212
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.92
    Marker Score: 1,142
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.92
    Marker Score: 1,870
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.92
    Marker Score: 352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,727
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.91
    Marker Score: 785
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.9
    Marker Score: 1,309
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.89
    Marker Score: 271
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.88
    Marker Score: 417
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.88
    Marker Score: 1,530
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.88
    Marker Score: 1,267
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,979
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.87
    Marker Score: 315
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.85
    Marker Score: 343
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.85
    Marker Score: 1,046
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.84
    Marker Score: 810
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.84
    Marker Score: 1,766
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4,910

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MEIS1 is a transcription factor that belongs to the MEIS family of homeobox genes. It is a DNA-binding protein that recognizes specific sequences in the promoter region of target genes, thereby regulating their expression. MEIS1 is characterized by its ability to activate or repress the expression of target genes, depending on the context. It is a transcriptional activator that regulates the expression of genes involved in cell growth, differentiation, and survival. MEIS1 is also involved in the regulation of angiogenesis, a process crucial for tissue development and repair. **Pathways and Functions** MEIS1 is involved in several developmental pathways, including: 1. **Anterior Hox Gene Activation**: MEIS1 is essential for the activation of anterior Hox genes during hindbrain development during early embryogenesis. 2. **Angiogenesis**: MEIS1 regulates the expression of genes involved in angiogenesis, a process critical for tissue development and repair. 3. **Cell Growth and Proliferation**: MEIS1 is involved in the regulation of cell growth and proliferation, particularly in the context of cardiac muscle cell development. 4. **Neuronal Differentiation**: MEIS1 regulates the expression of genes involved in neuronal differentiation, including those involved in the development of photoreceptor cells and chromaffin cells. 5. **Hemopoiesis**: MEIS1 is involved in the regulation of hematopoiesis, particularly in the context of megakaryocyte development. **Clinical Significance** Dysregulation of MEIS1 has been implicated in various diseases, including: 1. **Cancer**: MEIS1 has been found to be overexpressed in several types of cancer, including leukemia, lymphoma, and solid tumors. 2. **Developmental Disorders**: MEIS1 has been implicated in various developmental disorders, including autism, schizophrenia, and intellectual disability. 3. **Cardiovascular Disease**: MEIS1 has been found to be involved in the regulation of cardiac muscle cell development and has been implicated in the pathogenesis of cardiovascular disease. 4. **Neurological Disorders**: MEIS1 has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease. In conclusion, MEIS1 is a critical transcription factor that plays a crucial role in various developmental processes, including embryogenesis, organ morphogenesis, and cell growth. Its dysregulation has been linked to various diseases, highlighting the importance of MEIS1 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which MEIS1 regulates gene expression and to develop therapeutic strategies to target MEIS1 dysregulation in disease.

Genular Protein ID: 780022426

Symbol: MEIS1_HUMAN

Name: Homeobox protein Meis1

UniProtKB Accession Codes:

O00470 A8MV50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9226379

Title: Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene.

PubMed ID: 9226379

DOI: 10.1006/geno.1997.4766

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12609849

Title: Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene.

PubMed ID: 12609849

DOI: 10.1182/blood-2002-02-0380

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19799567

Title: PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region.

PubMed ID: 19799567

DOI: 10.1042/bj20090694

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26550823

Title: DNA-dependent formation of transcription factor pairs alters their binding specificity.

PubMed ID: 26550823

DOI: 10.1038/nature15518

PubMed ID: 28473536

Title: Impact of cytosine methylation on DNA binding specificities of human transcription factors.

PubMed ID: 28473536

DOI: 10.1126/science.aaj2239

PubMed ID: 19620614

Title: MEIS1 p.R272H in familial restless legs syndrome.

PubMed ID: 19620614

DOI: 10.1212/wnl.0b013e3181ae7c79

Sequence Information:

  • Length: 390
  • Mass: 43016
  • Checksum: 3B6A0ACCF0C39121
  • Sequence:
    • MAQRYDDLPH YGGMDGVGIP STMYGDPHAA RSMQPVHHLN HGPPLHSHQY PHTAHTNAMA 
PSMGSSVNDA LKRDKDAIYG HPLFPLLALI FEKCELATCT PREPGVAGGD VCSSESFNED 
IAVFAKQIRA EKPLFSSNPE LDNLMIQAIQ VLRFHLLELE KVHELCDNFC HRYISCLKGK 
MPIDLVIDDR EGGSKSDSED ITRSANLTDQ PSWNRDHDDT ASTRSGGTPG PSSGGHTSHS 
GDNSSEQGDG LDNSVASPST GDDDDPDKDK KRHKKRGIFP KVATNIMRAW LFQHLTHPYP 
SEEQKKQLAQ DTGLTILQVN NWFINARRRI VQPMIDQSNR AVSQGTPYNP DGQPMGGFVM 
DGQQHMGIRA PGPMSGMGMN MGMEGQWHYM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.