Details for: CL0000015

Cell ID: CL0000015

Cell Name: male germ cell

Marker Score Threshold: 288
(Derived using integrated single-cell and genomic data)

Description: A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.84
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.1
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.05
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.02
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.99
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.98
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.97
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.97
    Ensembl ID: ENSG00000152234
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.92
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.91
    Ensembl ID: ENSG00000185883
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.86
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.85
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.79
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.78
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.75
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.69
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.69
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.69
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.68
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.66
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.63
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.63
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.62
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.59
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.59
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.58
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.58
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.57
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.56
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.51
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.5
    Ensembl ID: ENSG00000204574
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.49
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.47
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.47
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.47
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BLMH (ENSG00000108578)
    Fold Change: 1.47
    Ensembl ID: ENSG00000108578
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.46
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.46
    Ensembl ID: ENSG00000177556
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.45
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.43
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.43
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.43
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.42
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.42
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.37
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.37
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.37
    Ensembl ID: ENSG00000099624
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.36
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.36
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.35
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.35
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ASNS (ENSG00000070669)
    Fold Change: 1.33
    Ensembl ID: ENSG00000070669
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.31
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.3
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.29
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.28
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BARD1 (ENSG00000138376)
    Fold Change: 1.26
    Ensembl ID: ENSG00000138376
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.25
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.25
    Ensembl ID: ENSG00000147416
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.24
    Ensembl ID: ENSG00000198356
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.21
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.2
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.2
    Ensembl ID: ENSG00000196961
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.2
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.19
    Ensembl ID: ENSG00000128272
  • Gene Symbol: POLR3D (ENSG00000168495)
    Fold Change: 1.19
    Ensembl ID: ENSG00000168495
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.19
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.18
    Ensembl ID: ENSG00000100412
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.18
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.17
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.17
    Ensembl ID: ENSG00000136717
  • Gene Symbol: BBS2 (ENSG00000125124)
    Fold Change: 1.16
    Ensembl ID: ENSG00000125124
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.15
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BRCA2 (ENSG00000139618)
    Fold Change: 1.15
    Ensembl ID: ENSG00000139618
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.15
    Ensembl ID: ENSG00000035687
  • Gene Symbol: BMI1 (ENSG00000168283)
    Fold Change: 1.12
    Ensembl ID: ENSG00000168283
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.11
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.1
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.1
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134287
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.09
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.08
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BFSP1 (ENSG00000125864)
    Fold Change: 1.08
    Ensembl ID: ENSG00000125864
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.08
    Ensembl ID: ENSG00000106605
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.07
    Ensembl ID: ENSG00000151914
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.05
    Ensembl ID: ENSG00000166747
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.05
    Ensembl ID: ENSG00000157764
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.04
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BYSL (ENSG00000112578)
    Fold Change: 1.04
    Ensembl ID: ENSG00000112578
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.02
    Ensembl ID: ENSG00000241837
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.02
    Ensembl ID: ENSG00000115307
Hovered Details

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Hovered Details

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**Key Characteristics** * Supports male gamete production * Found in the testes * Gene expression profile includes genes involved in: + Adaptive immune responses (B2M) + Antigen processing and presentation (B2M, ACTG1) + Cell signaling (ACTG1, ACTB) + Metabolism (ACTB) + Protein binding (ACTB) * Plays a crucial role in the development and maturation of sperm cells **Clinical Significance** The male germ cell is essential for male fertility and reproductive health. Abnormalities in the development or function of these cells can lead to male infertility, reproductive disorders, and increased susceptibility to infections. * Male infertility: Abnormalities in the development or function of male germ cells can lead to male infertility. * Reproductive disorders: Male germ cells play a crucial role in the development of male reproductive organs, and abnormalities in these cells can lead to reproductive disorders such as hypospadias and cryptorchidism. * Increased susceptibility to infections: Male germ cells are responsible for the production of sperm cells, which are an important component of the immune system. Abnormalities in the development or function of male germ cells can lead to increased susceptibility to infections. **Gene Symbol: B2M Ensembl ID: ENSG00000166710** The B2M gene is involved in adaptive immune responses and is expressed in male germ cells. It plays a crucial role in the processing and presentation of antigens to T-cells, which is essential for the development of immune responses. **Gene Symbol: ACTG1 Ensembl ID: ENSG00000184009** The ACTG1 gene is involved in cell signaling and is expressed in male germ cells. It plays a crucial role in the regulation of cell growth, differentiation, and survival. **Gene Symbol: ACTB Ensembl ID: ENSG00000075624** The ACTB gene is involved in cell signaling and is expressed in male germ cells. It plays a crucial role in the regulation of cell growth, differentiation, and survival. **Pathways/Ontology** The male germ cell is involved in various cellular processes, including: * Adaptive immune system * Amyloid fiber formation * Amyloid fibril formation * Antigen presentation: folding, assembly and peptide loading of class I MHC * Antigen processing-cross presentation * Antigen processing and presentation of endogenous peptide antigen via MHC class I * Antigen processing and presentation of exogenous peptide antigen via MHC class II * Antigen processing and presentation of exogenous protein antigen via MHC class Ib, tap-dependent * Bacterial infection pathways * Cellular response to iron(III) ion * Cellular response to iron ion * Cellular response to nicotine * Class I MHC-mediated antigen processing & presentation * Cytokine signaling in immune system * Cytosol * Dap12 interactions * Dap12 signaling * Disease * Early endosome lumen * Early endosome membrane * Endoplasmic reticulum * Endoplasmic reticulum lumen * Endosomal/vacuolar pathway * Er-phagosome pathway * Er to Golgi transport vesicle membrane * External side of plasma membrane * Extracellular exosome * Extracellular region * Extracellular space * Focal adhesion * Golgi apparatus * Golgi membrane * Hfe-transferrin receptor complex * HIV infection * Host interactions of HIV factors * Identical protein binding * Immune system * Immunoregulatory interactions between a lymphoid and a non-lymphoid cell * Infection with Mycobacterium tuberculosis * Infectious disease * Innate immune system * Interferon gamma signaling * Interferon signaling * Intracellular iron ion homeostasis * Iron ion transport * Late endosome membrane * Learning or memory * Lysosomal membrane * Membrane * Metabolism of proteins * MHC class II protein complex * MHC class II protein complex binding * MHC class I peptide loading complex * MHC class I protein complex * Modulation by MTB of host immune system * Multicellular organismal-level iron ion homeostasis * Nef mediates downmodulation of cell surface receptors by recruiting them to clathrin adapters * Nef-mediated downregulation of MHC class I complex cell surface expression * Negative regulation of epithelial cell proliferation * Negative regulation of forebrain neuron differentiation * Negative regulation of neurogenesis * Negative regulation of neuron projection development * Negative regulation of receptor binding * Neutrophil degranulation * Peptide antigen assembly with MHC class II protein complex * Peptide antigen assembly with MHC class I protein complex * Peptide antigen binding * Phagocytic vesicle membrane * Plasma membrane * Positive regulation of cellular senescence * Positive regulation of ferrous iron binding * Positive regulation of immune response * Positive regulation of protein binding * Positive regulation of receptor-mediated endocytosis * Positive regulation of receptor binding * Positive regulation of T-cell activation * Positive regulation of T-cell cytokine production * Positive regulation of T-cell mediated cytotoxicity * Positive regulation of transferrin receptor binding * Protein binding * Protein homodimerization activity * Protein homotetramerization * Protein refolding * Recycling endosome membrane * Regulation of erythrocyte differentiation * Regulation of iron ion transport * Response to molecule of bacterial origin * SARS-CoV-2 activates/modulates innate and adaptive immune responses * SARS-CoV-2 infection * SARS-CoV infections * Sensory perception of smell * Specific granule lumen * Structural molecule activity * T-cell differentiation in thymus * T-cell mediated cytotoxicity * Tertiary granule lumen * The role of Nef in HIV-1 replication and disease pathogenesis * Viral infection pathways