Details for: CL0000015

Cell ID: CL0000015

Cell Name: male germ cell

Marker Score Threshold: 288
(Derived using integrated single-cell and genomic data)

Description: A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: MAGEA2 (ENSG00000268606)
    Fold Change: 4.36
    Ensembl ID: ENSG00000268606
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.84
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CTAG1B (ENSG00000184033)
    Fold Change: 2.55
    Ensembl ID: ENSG00000184033
  • Gene Symbol: GK2 (ENSG00000196475)
    Fold Change: 2.39
    Ensembl ID: ENSG00000196475
  • Gene Symbol: JUNB (ENSG00000171223)
    Fold Change: 2.35
    Ensembl ID: ENSG00000171223
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 2.31
    Ensembl ID: ENSG00000204525
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.27
    Ensembl ID: ENSG00000234745
  • Gene Symbol: HLA E (ENSG00000204592)
    Fold Change: 2.26
    Ensembl ID: ENSG00000204592
  • Gene Symbol: GSC2 (ENSG00000063515)
    Fold Change: 2.23
    Ensembl ID: ENSG00000063515
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.12
    Ensembl ID: ENSG00000156508
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.11
    Ensembl ID: ENSG00000080824
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.11
    Ensembl ID: ENSG00000168028
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.1
    Ensembl ID: ENSG00000132475
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.1
    Ensembl ID: ENSG00000184009
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.1
    Ensembl ID: ENSG00000096384
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.09
    Ensembl ID: ENSG00000198804
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2.09
    Ensembl ID: ENSG00000198712
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.09
    Ensembl ID: ENSG00000087086
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.08
    Ensembl ID: ENSG00000167996
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.08
    Ensembl ID: ENSG00000198938
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.07
    Ensembl ID: ENSG00000114942
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.07
    Ensembl ID: ENSG00000198727
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 2.06
    Ensembl ID: ENSG00000196531
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.06
    Ensembl ID: ENSG00000122566
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.06
    Ensembl ID: ENSG00000111640
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.06
    Ensembl ID: ENSG00000189403
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.06
    Ensembl ID: ENSG00000198899
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.05
    Ensembl ID: ENSG00000109971
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.05
    Ensembl ID: ENSG00000075624
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.04
    Ensembl ID: ENSG00000167658
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 2.04
    Ensembl ID: ENSG00000198840
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 2.04
    Ensembl ID: ENSG00000198886
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.04
    Ensembl ID: ENSG00000149806
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 2.04
    Ensembl ID: ENSG00000092841
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.03
    Ensembl ID: ENSG00000108654
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 2.03
    Ensembl ID: ENSG00000163041
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 2.03
    Ensembl ID: ENSG00000135486
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.02
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.02
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 2.02
    Ensembl ID: ENSG00000212907
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.01
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 1.99
    Ensembl ID: ENSG00000198763
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.99
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 1.99
    Ensembl ID: ENSG00000198786
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.98
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.97
    Ensembl ID: ENSG00000145741
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 1.97
    Ensembl ID: ENSG00000170345
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.97
    Ensembl ID: ENSG00000152234
  • Gene Symbol: EIF5 (ENSG00000100664)
    Fold Change: 1.97
    Ensembl ID: ENSG00000100664
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.96
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.96
    Ensembl ID: ENSG00000127184
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 1.96
    Ensembl ID: ENSG00000126777
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.95
    Ensembl ID: ENSG00000111775
  • Gene Symbol: DNAJA1 (ENSG00000086061)
    Fold Change: 1.94
    Ensembl ID: ENSG00000086061
  • Gene Symbol: XRCC6 (ENSG00000196419)
    Fold Change: 1.93
    Ensembl ID: ENSG00000196419
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 1.93
    Ensembl ID: ENSG00000165119
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.92
    Ensembl ID: ENSG00000169100
  • Gene Symbol: HSPD1 (ENSG00000144381)
    Fold Change: 1.92
    Ensembl ID: ENSG00000144381
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.91
    Ensembl ID: ENSG00000185883
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 1.91
    Ensembl ID: ENSG00000153187
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.9
    Ensembl ID: ENSG00000108561
  • Gene Symbol: HDAC2 (ENSG00000196591)
    Fold Change: 1.9
    Ensembl ID: ENSG00000196591
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.89
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CKS2 (ENSG00000123975)
    Fold Change: 1.87
    Ensembl ID: ENSG00000123975
  • Gene Symbol: HSPE1 (ENSG00000115541)
    Fold Change: 1.87
    Ensembl ID: ENSG00000115541
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 1.86
    Ensembl ID: ENSG00000169567
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 1.86
    Ensembl ID: ENSG00000206503
  • Gene Symbol: JUN (ENSG00000177606)
    Fold Change: 1.86
    Ensembl ID: ENSG00000177606
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.86
    Ensembl ID: ENSG00000099622
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.86
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.86
    Ensembl ID: ENSG00000051523
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 1.86
    Ensembl ID: ENSG00000198830
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.85
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.85
    Ensembl ID: ENSG00000157514
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 1.85
    Ensembl ID: ENSG00000167004
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 1.85
    Ensembl ID: ENSG00000106211
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.85
    Ensembl ID: ENSG00000146731
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.84
    Ensembl ID: ENSG00000135940
  • Gene Symbol: ELAVL2 (ENSG00000107105)
    Fold Change: 1.84
    Ensembl ID: ENSG00000107105
  • Gene Symbol: HNRNPF (ENSG00000169813)
    Fold Change: 1.84
    Ensembl ID: ENSG00000169813
  • Gene Symbol: LDHB (ENSG00000111716)
    Fold Change: 1.84
    Ensembl ID: ENSG00000111716
  • Gene Symbol: ATP8 (ENSG00000228253)
    Fold Change: 1.84
    Ensembl ID: ENSG00000228253
  • Gene Symbol: ITGB1 (ENSG00000150093)
    Fold Change: 1.82
    Ensembl ID: ENSG00000150093
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.82
    Ensembl ID: ENSG00000134825
  • Gene Symbol: HOXC12 (ENSG00000123407)
    Fold Change: 1.82
    Ensembl ID: ENSG00000123407
  • Gene Symbol: NAP1L1 (ENSG00000187109)
    Fold Change: 1.8
    Ensembl ID: ENSG00000187109
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.8
    Ensembl ID: ENSG00000155368
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.8
    Ensembl ID: ENSG00000156976
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.79
    Ensembl ID: ENSG00000154518
  • Gene Symbol: MAGEB2 (ENSG00000099399)
    Fold Change: 1.79
    Ensembl ID: ENSG00000099399
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.79
    Ensembl ID: ENSG00000172757
  • Gene Symbol: STMN1 (ENSG00000117632)
    Fold Change: 1.78
    Ensembl ID: ENSG00000117632
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.78
    Ensembl ID: ENSG00000069849
  • Gene Symbol: HSPA4 (ENSG00000170606)
    Fold Change: 1.78
    Ensembl ID: ENSG00000170606
  • Gene Symbol: ID1 (ENSG00000125968)
    Fold Change: 1.78
    Ensembl ID: ENSG00000125968
  • Gene Symbol: NAP1L4 (ENSG00000205531)
    Fold Change: 1.78
    Ensembl ID: ENSG00000205531
  • Gene Symbol: HMGB2 (ENSG00000164104)
    Fold Change: 1.77
    Ensembl ID: ENSG00000164104
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.76
    Ensembl ID: ENSG00000120129
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.75
    Ensembl ID: ENSG00000110955

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in male germ cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in male germ cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Cell Type**: Male germ cell, responsible for producing male gametes. 2. **Genes**: MAGEA2, B2M, CTAG1B, GK2, and JUNB, which are involved in various cellular processes. 3. **Pathways/Ontologies**: Cellular senescence, antigen presentation, DNA-binding transcription factor binding, cellular response to calcium ion, and DNA-binding transcription factor activity. 4. **Cellular Processes**: Spermatogenesis, antigen processing, and presentation, cellular senescence, and transcription regulation. 5. **Interactions**: Interacts with non-germ cells such as Sertoli cells to facilitate spermatogenesis. **Clinical Significance** 1. **Reproductive Disorders**: Abnormalities in male germ cell function can lead to reproductive disorders such as infertility, azoospermia, and cryptorchidism. 2. **Immune System**: The male germ cell's ability to present antigens to the immune system is crucial for maintaining immune homeostasis and preventing autoimmune diseases. 3. **Cancer**: Abnormalities in the MAGEA2 gene have been associated with cancer, including melanoma and testicular cancer. 4. **Infectious Diseases**: The male germ cell's ability to present antigens to the immune system is also crucial for fighting off infections, including HIV and tuberculosis. 5. **Regenerative Medicine**: Understanding the cellular processes involved in spermatogenesis can provide insights into regenerative medicine, including the development of novel therapies for male infertility and reproductive disorders. In conclusion, the male germ cell is a critical cell type involved in reproductive processes, and its dysfunction can lead to various clinical disorders. Further research is needed to fully understand the cellular processes involved in spermatogenesis and to develop novel therapies for male reproductive disorders.