Details for: CL0000037

Cell ID: CL0000037

Cell Name: hematopoietic stem cell

Marker Score Threshold: 527
(Derived using integrated single-cell and genomic data)

Description: A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.

Synonyms: blood forming stem cell, hemopoietic stem cell, HSC, colony forming unit hematopoietic

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ADRA1D (ENSG00000171873)
    Fold Change: 4.97
    Ensembl ID: ENSG00000171873
  • Gene Symbol: BNC1 (ENSG00000169594)
    Fold Change: 4.97
    Ensembl ID: ENSG00000169594
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 4.77
    Ensembl ID: ENSG00000163485
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 4.49
    Ensembl ID: ENSG00000124812
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: 4.29
    Ensembl ID: ENSG00000198691
  • Gene Symbol: AMBN (ENSG00000178522)
    Fold Change: 3.78
    Ensembl ID: ENSG00000178522
  • Gene Symbol: OPN1SW (ENSG00000128617)
    Fold Change: 3.31
    Ensembl ID: ENSG00000128617
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.13
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.88
    Ensembl ID: ENSG00000169100
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.87
    Ensembl ID: ENSG00000166710
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.76
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.72
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.67
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.58
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.54
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.52
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.5
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.35
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.32
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.3
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.21
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.2
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.14
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.09
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.07
    Ensembl ID: ENSG00000172270
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.06
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.04
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: 2.03
    Ensembl ID: ENSG00000110881
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.01
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.96
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.94
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.91
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.88
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.85
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.84
    Ensembl ID: ENSG00000004059
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.84
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.83
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.8
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.78
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.74
    Ensembl ID: ENSG00000136881
  • Gene Symbol: ART1 (ENSG00000129744)
    Fold Change: 1.73
    Ensembl ID: ENSG00000129744
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.7
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.67
    Ensembl ID: ENSG00000084234
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.66
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.62
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.6
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.54
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.54
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.54
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.49
    Ensembl ID: ENSG00000130303
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.47
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.45
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.44
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.44
    Ensembl ID: ENSG00000123505
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 1.43
    Ensembl ID: ENSG00000171885
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.43
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.41
    Ensembl ID: ENSG00000069849
  • Gene Symbol: AGRP (ENSG00000159723)
    Fold Change: 1.41
    Ensembl ID: ENSG00000159723
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.39
    Ensembl ID: ENSG00000204472
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.36
    Ensembl ID: ENSG00000177105
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.35
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.35
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.35
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.34
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.34
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.33
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.33
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 1.31
    Ensembl ID: ENSG00000120907
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.28
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BRDT (ENSG00000137948)
    Fold Change: 1.28
    Ensembl ID: ENSG00000137948
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.26
    Ensembl ID: ENSG00000135046
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104964
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 1.22
    Ensembl ID: ENSG00000165462
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 1.19
    Ensembl ID: ENSG00000160683
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.18
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 1.17
    Ensembl ID: ENSG00000139352
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.17
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.16
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BTN1A1 (ENSG00000124557)
    Fold Change: 1.15
    Ensembl ID: ENSG00000124557
  • Gene Symbol: KLK3 (ENSG00000142515)
    Fold Change: 1.15
    Ensembl ID: ENSG00000142515
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.14
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.13
    Ensembl ID: ENSG00000170214
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.13
    Ensembl ID: ENSG00000163631
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.11
    Ensembl ID: ENSG00000148700
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.11
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.1
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.09
    Ensembl ID: ENSG00000140299
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.08
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.08
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.07
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.03
    Ensembl ID: ENSG00000106605
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.01
    Ensembl ID: ENSG00000010671
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149131
  • Gene Symbol: C4BPA (ENSG00000123838)
    Fold Change: 1
    Ensembl ID: ENSG00000123838
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Lin-negative**: Hematopoietic stem cells lack cell surface markers of effector cells, making them distinct from other types of stem cells. 2. **Multipotent**: Hematopoietic stem cells have the ability to differentiate into all cells of the lymphoid and myeloid lineages. 3. **Self-renewal**: Hematopoietic stem cells have the ability to self-renew, allowing them to maintain their population over time. 4. **Differentiation**: Hematopoietic stem cells can differentiate into various cell types, including blood cells, immune cells, and cells of the nervous system. 5. **Cell surface markers**: Hematopoietic stem cells do not express cell surface markers of effector cells, such as CD2, CD3 epsilon, CD4, CD5, CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, and ter119. **Clinical Significance** 1. **Blood cell disorders**: Hematopoietic stem cells play a critical role in the development of blood cells, and disorders in these cells can lead to blood cell disorders such as anemia, leukemia, and lymphoma. 2. **Immunological disorders**: Hematopoietic stem cells are involved in the development of immune cells, and disorders in these cells can lead to immunological disorders such as autoimmune diseases and immunodeficiency diseases. 3. **Cancer treatment**: Hematopoietic stem cells have been used in cancer treatment, such as bone marrow transplantation, to replace damaged or cancerous cells with healthy cells. 4. **Regenerative medicine**: Hematopoietic stem cells have the potential to be used in regenerative medicine to repair or replace damaged tissues, such as bone marrow and immune cells. 5. **Gene therapy**: Hematopoietic stem cells can be used as a target for gene therapy to treat genetic disorders, such as sickle cell anemia and beta-thalassemia. In conclusion, hematopoietic stem cells are critical for the development of blood cells and immune cells, and disorders in these cells can lead to various clinical disorders. Understanding the characteristics and clinical significance of hematopoietic stem cells is essential for the development of new treatments and therapies for blood cell and immunological disorders.