Details for: CL0000049

Cell ID: CL0000049

Cell Name: common myeloid progenitor

Marker Score Threshold: 265
(Derived using integrated single-cell and genomic data)

Description: A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.

Synonyms: common myeloid precursor, CFU-GEMM, CFU-S, CMP, colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte, multipotential myeloid stem cell, myeloid stem cell, pluripotent stem cell (bone marrow)

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.83
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.71
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.05
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.98
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.97
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.91
    Ensembl ID: ENSG00000099622
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.8
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.72
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.7
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.47
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.47
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.43
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.32
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.22
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.16
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.13
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.08
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.08
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.07
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.95
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.86
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.85
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.83
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.81
    Ensembl ID: ENSG00000153113
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.79
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.79
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.78
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.78
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.77
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.72
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.72
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.7
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.66
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.66
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.65
    Ensembl ID: ENSG00000117410
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.62
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.61
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.61
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.55
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.52
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.51
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.48
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.48
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.48
    Ensembl ID: ENSG00000116489
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.47
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.45
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.45
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.43
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.43
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.43
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.42
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.41
    Ensembl ID: ENSG00000141522
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.41
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.41
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.4
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.4
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.38
    Ensembl ID: ENSG00000159199
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.33
    Ensembl ID: ENSG00000146731
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.31
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.31
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.3
    Ensembl ID: ENSG00000112576
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.29
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.29
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.26
    Ensembl ID: ENSG00000122359
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.24
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.22
    Ensembl ID: ENSG00000177556
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.22
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.22
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.21
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.2
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.2
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.19
    Ensembl ID: ENSG00000109861
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.17
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.14
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.14
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.14
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.14
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.13
    Ensembl ID: ENSG00000134480
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.12
    Ensembl ID: ENSG00000162909
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.12
    Ensembl ID: ENSG00000105254
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.1
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.1
    Ensembl ID: ENSG00000172216
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.09
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143727
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.08
    Ensembl ID: ENSG00000183255
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.08
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.05
    Ensembl ID: ENSG00000111642
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149311
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149823
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.02
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1
    Ensembl ID: ENSG00000127837
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Multipotency**: CMPs have the ability to differentiate into multiple cell types within the myeloid lineage, including megakaryocytes, erythrocytes, granulocytes, macrophages, and dendritic cells. 2. **Adhesion properties**: CMPs express adhesion molecules that enable them to interact with the bone marrow microenvironment and migrate to specific niches. 3. **Self-renewal**: CMPs have the ability to self-renew, allowing them to maintain their population and replenish the hematopoietic system. 4. **Differentiation**: CMPs can differentiate into mature myeloid cells, which are responsible for producing various immune cells and blood cells. **Clinical Significance** 1. **Blood disorders**: CMPs are involved in the development of various blood disorders, including leukemia, lymphoma, and aplastic anemia. 2. **Immunodeficiency**: CMPs play a crucial role in the development of the immune system, and defects in CMP function can lead to immunodeficiency. 3. **Bone marrow transplantation**: CMPs are essential for the success of bone marrow transplantation, as they are responsible for repopulating the recipient's hematopoietic system. 4. **Cancer research**: CMPs are used as a model system to study the development and progression of cancer, as they can differentiate into cancer cells. **Functional Roles** 1. **Hematopoiesis**: CMPs are responsible for producing new blood cells, including red blood cells, white blood cells, and platelets. 2. **Immune cell development**: CMPs differentiate into immune cells, including dendritic cells, macrophages, and granulocytes, which are essential for the immune response. 3. **Bone marrow microenvironment**: CMPs interact with the bone marrow microenvironment, including osteoblasts, osteoclasts, and stromal cells, to maintain the hematopoietic system. 4. **Regulation of hematopoiesis**: CMPs are regulated by various signaling pathways, including the Wnt/β-catenin pathway, which is essential for their development and function. In conclusion, the Common Myeloid Progenitor is a crucial cell type in the hematopoietic system, responsible for producing new blood cells and immune cells. Its multipotency, adhesion properties, self-renewal, and differentiation capabilities make it an essential component of the bone marrow microenvironment. Understanding the functional roles of CMPs is essential for the development of novel therapeutic strategies for blood disorders and cancer.