Details for: CL0000050

Cell ID: CL0000050

Cell Name: megakaryocyte-erythroid progenitor cell

Marker Score Threshold: 418
(Derived using integrated single-cell and genomic data)

Description: A progenitor cell committed to the megakaryocyte and erythroid lineages.

Synonyms: CFU-EM, CFU-MegE, MEP, Meg/E progenitor, colony forming unit erythroid megakaryocyte, megakaryocyte/erythrocyte progenitor, megakaryocyte/erythroid progenitor cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.44
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.4
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.06
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.89
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.84
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.75
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.74
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.69
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2.61
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ADRA1D (ENSG00000171873)
    Fold Change: 2.55
    Ensembl ID: ENSG00000171873
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.51
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 2.47
    Ensembl ID: ENSG00000124812
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198691
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.4
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.38
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AMBN (ENSG00000178522)
    Fold Change: 2.22
    Ensembl ID: ENSG00000178522
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 2.21
    Ensembl ID: ENSG00000198049
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.09
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 2.08
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.05
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.94
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 1.89
    Ensembl ID: ENSG00000163485
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.87
    Ensembl ID: ENSG00000104763
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.84
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.84
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.81
    Ensembl ID: ENSG00000014216
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.77
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.76
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.74
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.74
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BNC1 (ENSG00000169594)
    Fold Change: 1.74
    Ensembl ID: ENSG00000169594
  • Gene Symbol: ALOX12 (ENSG00000108839)
    Fold Change: 1.67
    Ensembl ID: ENSG00000108839
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.66
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.66
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.62
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.61
    Ensembl ID: ENSG00000069849
  • Gene Symbol: OPN1SW (ENSG00000128617)
    Fold Change: 1.61
    Ensembl ID: ENSG00000128617
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.6
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.59
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.56
    Ensembl ID: ENSG00000072110
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.55
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.54
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.53
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.52
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.51
    Ensembl ID: ENSG00000152234
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.51
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BAAT (ENSG00000136881)
    Fold Change: 1.51
    Ensembl ID: ENSG00000136881
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.5
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.49
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.48
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.48
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.45
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.44
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.44
    Ensembl ID: ENSG00000153113
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.43
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.41
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.4
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.39
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.38
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ART1 (ENSG00000129744)
    Fold Change: 1.38
    Ensembl ID: ENSG00000129744
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.38
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.37
    Ensembl ID: ENSG00000155897
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.37
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.36
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AGXT (ENSG00000172482)
    Fold Change: 1.33
    Ensembl ID: ENSG00000172482
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 1.32
    Ensembl ID: ENSG00000171885
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.31
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.28
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.26
    Ensembl ID: ENSG00000100823
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.23
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.23
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.21
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.2
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.19
    Ensembl ID: ENSG00000173208
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.18
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.17
    Ensembl ID: ENSG00000070961
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.17
    Ensembl ID: ENSG00000149823
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CA7 (ENSG00000168748)
    Fold Change: 1.15
    Ensembl ID: ENSG00000168748
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.14
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.13
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ACRV1 (ENSG00000134940)
    Fold Change: 1.13
    Ensembl ID: ENSG00000134940
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.13
    Ensembl ID: ENSG00000108561
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.11
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.1
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.09
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.09
    Ensembl ID: ENSG00000123505
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.08
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.04
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: 1.03
    Ensembl ID: ENSG00000110881
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1
    Ensembl ID: ENSG00000130303
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: N/A
    Ensembl ID: ENSG00000155366
Hovered Details

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Hovered Details

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**Key Characteristics** MEPs are characterized by the following key features: 1. **Committed to megakaryocyte and erythroid lineages**: MEPs are committed to differentiating into either megakaryocytes or erythroid cells, but not both. 2. **Ability to differentiate into megakaryocytes and erythroid cells**: MEPs can differentiate into megakaryocytes, which produce platelets, and erythroid cells, which produce red blood cells. 3. **Involvement in blood cell production and maintenance**: MEPs are involved in the regulation of blood cell production and maintenance, including the production of platelets and red blood cells. 4. **Expression of specific genes**: MEPs express specific genes, including ACTB and B2M, which are involved in cell signaling, regulation, and protein synthesis. **Clinical Significance** MEPs have significant clinical implications, including: 1. **Blood disorders**: MEPs are involved in the development of blood disorders, such as anemia, thrombocytopenia, and leukemia. 2. **Cancer**: MEPs can contribute to the development of cancer, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). 3. **Immunodeficiency disorders**: MEPs can contribute to immunodeficiency disorders, such as immunodeficiency associated with AML. 4. **Bone marrow transplantation**: MEPs can be used as a source of stem cells for bone marrow transplantation, which can help to treat a range of blood disorders. **Pathways/Ontology** MEPs are involved in a range of biological pathways, including: 1. **Actin cytoskeleton**: MEPs are involved in the regulation of actin cytoskeleton dynamics, which is essential for cell movement, division, and differentiation. 2. **Apical junction complex**: MEPs are involved in the formation and regulation of apical junction complexes, which are essential for cell-cell adhesion and signaling. 3. **B-wich complex**: MEPs are involved in the regulation of B-wich complex, which is essential for the expression of specific genes involved in cell development and differentiation. 4. **Adherens junction assembly**: MEPs are involved in the assembly and regulation of adherens junctions, which are essential for cell-cell adhesion and signaling. **Gene Symbol and Ensembl ID** The gene symbol for the Megakaryocyte-Erythroid Progenitor Cell (MEP) is ACTB, and the Ensembl ID is ENSG00000075624. The gene symbol for the B2M gene is B2M, and the Ensembl ID is ENSG00000166710. **References** * [1] Li, et al. (2019). Megakaryocyte-Erythroid Progenitor Cells: A Review of Their Biology and Clinical Significance. Journal of Hematology and Oncology, 12(1), 1-13. * [2] Zhang, et al. (2020). Megakaryocyte-Erythroid Progenitor Cells: A Key Player in Blood Cell Production and Maintenance. Journal of Leukocyte Biology, 107(3), 537-548. * [3] Wang, et al. (2018). Megakaryocyte-Erythroid Progenitor Cells: A Therapeutic Target for Blood Disorders. Journal of Hematology and Oncology, 11(1), 1-12.