Details for: CL0000062

Cell ID: CL0000062

Cell Name: osteoblast

Marker Score Threshold: 537
(Derived using integrated single-cell and genomic data)

Description: Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.68
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.62
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.46
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.41
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.35
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.34
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.34
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.24
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.22
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.22
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.21
    Ensembl ID: ENSG00000179218
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.19
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.15
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.13
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.06
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.06
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.02
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.02
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.01
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.97
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.92
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.92
    Ensembl ID: ENSG00000110955
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.89
    Ensembl ID: ENSG00000175899
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.87
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.84
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.83
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.8
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.79
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.78
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 1.77
    Ensembl ID: ENSG00000162551
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.75
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.75
    Ensembl ID: ENSG00000168374
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.75
    Ensembl ID: ENSG00000005022
  • Gene Symbol: RUNX2 (ENSG00000124813)
    Fold Change: 1.75
    Ensembl ID: ENSG00000124813
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.74
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.71
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.7
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.67
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.64
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.63
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.62
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.61
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.59
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.55
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.55
    Ensembl ID: ENSG00000128272
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.51
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.49
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.49
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.48
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.47
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.46
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.44
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.43
    Ensembl ID: ENSG00000159199
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.4
    Ensembl ID: ENSG00000108561
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.39
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.37
    Ensembl ID: ENSG00000019582
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.36
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.35
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.34
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.34
    Ensembl ID: ENSG00000128595
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.33
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.33
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.32
    Ensembl ID: ENSG00000197043
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.32
    Ensembl ID: ENSG00000138760
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.29
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.29
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.27
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.24
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.24
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.23
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.23
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.21
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.19
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.19
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.19
    Ensembl ID: ENSG00000198363
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.18
    Ensembl ID: ENSG00000004455
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.18
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.14
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.13
    Ensembl ID: ENSG00000156110
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.12
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.12
    Ensembl ID: ENSG00000121691
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.11
    Ensembl ID: ENSG00000137845
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143799
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.1
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.09
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.07
    Ensembl ID: ENSG00000071553
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149131
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.05
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.05
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.04
    Ensembl ID: ENSG00000107262
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.03
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: N/A
    Ensembl ID: ENSG00000135218
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Bone formation**: Osteoblasts are responsible for producing osteoid, a non-mineralized matrix, which is then mineralized to form hydroxyapatite. 2. **Cellular origin**: Osteoblasts arise from the transformation of preosteoblast cells. 3. **Location**: Osteoblasts are located adjacent to or within osteoid tissue. 4. **Gene expression**: Osteoblasts express a range of genes involved in bone formation, including ACTB and B2M. 5. **Signaling pathways**: Osteoblasts are regulated by a complex interplay of signaling pathways, including those involved in cell proliferation, differentiation, and survival. **Clinical Significance** 1. **Bone disorders**: Osteoblast dysfunction can lead to a range of bone disorders, including osteoporosis, osteopenia, and bone cancer. 2. **Regenerative medicine**: Osteoblasts have the potential to be used in regenerative medicine to repair or replace damaged bone tissue. 3. **Bone grafting**: Osteoblasts can be used to enhance bone grafting procedures by promoting bone growth and repair. 4. **Cancer treatment**: Osteoblasts have been shown to have anti-tumor properties and may be used as a target for cancer therapy. 5. **Infectious disease**: Osteoblasts play a role in the immune response to infection and may be involved in the pathogenesis of osteomyelitis. **Pathways/Ontology** Osteoblasts are involved in a range of signaling pathways, including: 1. **Actin cytoskeleton**: Osteoblasts use actin filaments to regulate cell shape and movement. 2. **Adherens junctions**: Osteoblasts use adherens junctions to regulate cell-cell interactions. 3. **Apical junction complex**: Osteoblasts use the apical junction complex to regulate cell-cell interactions. 4. **B-wich complex**: The B-wich complex is involved in the regulation of RNA expression in osteoblasts. 5. **Cytokine signaling**: Osteoblasts are involved in cytokine signaling, including the regulation of immune responses. 6. **Epigenetic regulation**: Osteoblasts use epigenetic mechanisms to regulate gene expression. 7. **Golgi apparatus**: Osteoblasts use the Golgi apparatus to regulate protein processing and secretion. 8. **Innate immune system**: Osteoblasts play a role in the innate immune response to infection. 9. **Interferon signaling**: Osteoblasts are involved in interferon signaling, which regulates immune responses. 10. **Mitochondrial function**: Osteoblasts use mitochondrial function to regulate energy metabolism. Overall, osteoblasts play a critical role in bone formation and maintenance, and their dysfunction can lead to a range of bone disorders. Understanding the signaling pathways involved in osteoblast function can provide insights into the development of new treatments for bone-related diseases.