Details for: CL0000062

Cell ID: CL0000062

Cell Name: osteoblast

Marker Score Threshold: 537
(Derived using integrated single-cell and genomic data)

Description: Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.68
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.66
    Ensembl ID: ENSG00000167996
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.62
    Ensembl ID: ENSG00000166710
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.61
    Ensembl ID: ENSG00000087086
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.6
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.59
    Ensembl ID: ENSG00000149806
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.59
    Ensembl ID: ENSG00000132475
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.57
    Ensembl ID: ENSG00000111640
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 2.55
    Ensembl ID: ENSG00000092841
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.53
    Ensembl ID: ENSG00000080824
  • Gene Symbol: RPL10A (ENSG00000198755)
    Fold Change: 2.51
    Ensembl ID: ENSG00000198755
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.5
    Ensembl ID: ENSG00000122566
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 2.5
    Ensembl ID: ENSG00000196531
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198804
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198938
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2.46
    Ensembl ID: ENSG00000198712
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.46
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.45
    Ensembl ID: ENSG00000168028
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.45
    Ensembl ID: ENSG00000189403
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 2.44
    Ensembl ID: ENSG00000198899
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 2.44
    Ensembl ID: ENSG00000198727
  • Gene Symbol: PFDN5 (ENSG00000123349)
    Fold Change: 2.44
    Ensembl ID: ENSG00000123349
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.44
    Ensembl ID: ENSG00000096384
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 2.43
    Ensembl ID: ENSG00000198886
  • Gene Symbol: ND1 (ENSG00000198888)
    Fold Change: 2.42
    Ensembl ID: ENSG00000198888
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 2.42
    Ensembl ID: ENSG00000198840
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.42
    Ensembl ID: ENSG00000172757
  • Gene Symbol: PPIA (ENSG00000196262)
    Fold Change: 2.41
    Ensembl ID: ENSG00000196262
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.41
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.4
    Ensembl ID: ENSG00000127184
  • Gene Symbol: ND2 (ENSG00000198763)
    Fold Change: 2.4
    Ensembl ID: ENSG00000198763
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.4
    Ensembl ID: ENSG00000167658
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 2.4
    Ensembl ID: ENSG00000163041
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.4
    Ensembl ID: ENSG00000104529
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.39
    Ensembl ID: ENSG00000131143
  • Gene Symbol: PFN1 (ENSG00000108518)
    Fold Change: 2.39
    Ensembl ID: ENSG00000108518
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.35
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.34
    Ensembl ID: ENSG00000169100
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 2.34
    Ensembl ID: ENSG00000135486
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.34
    Ensembl ID: ENSG00000124172
  • Gene Symbol: NPM1 (ENSG00000181163)
    Fold Change: 2.32
    Ensembl ID: ENSG00000181163
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.31
    Ensembl ID: ENSG00000099622
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.3
    Ensembl ID: ENSG00000108654
  • Gene Symbol: NDUFA4 (ENSG00000189043)
    Fold Change: 2.3
    Ensembl ID: ENSG00000189043
  • Gene Symbol: ND5 (ENSG00000198786)
    Fold Change: 2.29
    Ensembl ID: ENSG00000198786
  • Gene Symbol: OAZ1 (ENSG00000104904)
    Fold Change: 2.29
    Ensembl ID: ENSG00000104904
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.29
    Ensembl ID: ENSG00000165119
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 2.27
    Ensembl ID: ENSG00000206503
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.26
    Ensembl ID: ENSG00000114942
  • Gene Symbol: PCBP2 (ENSG00000197111)
    Fold Change: 2.25
    Ensembl ID: ENSG00000197111
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.24
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.24
    Ensembl ID: ENSG00000126267
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.23
    Ensembl ID: ENSG00000169567
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.22
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.22
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.21
    Ensembl ID: ENSG00000179218
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.21
    Ensembl ID: ENSG00000092199
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.2
    Ensembl ID: ENSG00000164919
  • Gene Symbol: NAP1L1 (ENSG00000187109)
    Fold Change: 2.2
    Ensembl ID: ENSG00000187109
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.19
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.19
    Ensembl ID: ENSG00000112695
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 2.19
    Ensembl ID: ENSG00000204525
  • Gene Symbol: PPIB (ENSG00000166794)
    Fold Change: 2.18
    Ensembl ID: ENSG00000166794
  • Gene Symbol: YBX1 (ENSG00000065978)
    Fold Change: 2.18
    Ensembl ID: ENSG00000065978
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.16
    Ensembl ID: ENSG00000156976
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.15
    Ensembl ID: ENSG00000234745
  • Gene Symbol: PSAP (ENSG00000197746)
    Fold Change: 2.15
    Ensembl ID: ENSG00000197746
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.15
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.15
    Ensembl ID: ENSG00000198668
  • Gene Symbol: EIF3E (ENSG00000104408)
    Fold Change: 2.14
    Ensembl ID: ENSG00000104408
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.13
    Ensembl ID: ENSG00000135940
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.13
    Ensembl ID: ENSG00000167468
  • Gene Symbol: HMGN1 (ENSG00000205581)
    Fold Change: 2.13
    Ensembl ID: ENSG00000205581
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 2.13
    Ensembl ID: ENSG00000167004
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.13
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 2.12
    Ensembl ID: ENSG00000074800
  • Gene Symbol: LDHA (ENSG00000134333)
    Fold Change: 2.11
    Ensembl ID: ENSG00000134333
  • Gene Symbol: SLC25A3 (ENSG00000075415)
    Fold Change: 2.1
    Ensembl ID: ENSG00000075415
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.1
    Ensembl ID: ENSG00000109971
  • Gene Symbol: HSPA5 (ENSG00000044574)
    Fold Change: 2.09
    Ensembl ID: ENSG00000044574
  • Gene Symbol: ND4L (ENSG00000212907)
    Fold Change: 2.09
    Ensembl ID: ENSG00000212907
  • Gene Symbol: HMGN2 (ENSG00000198830)
    Fold Change: 2.08
    Ensembl ID: ENSG00000198830
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.07
    Ensembl ID: ENSG00000122545
  • Gene Symbol: NDUFS5 (ENSG00000168653)
    Fold Change: 2.07
    Ensembl ID: ENSG00000168653
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.06
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.06
    Ensembl ID: ENSG00000134825
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.05
    Ensembl ID: ENSG00000087460
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.05
    Ensembl ID: ENSG00000176340
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 2.05
    Ensembl ID: ENSG00000164733
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 2.04
    Ensembl ID: ENSG00000084207
  • Gene Symbol: LDHB (ENSG00000111716)
    Fold Change: 2.03
    Ensembl ID: ENSG00000111716
  • Gene Symbol: PRDX1 (ENSG00000117450)
    Fold Change: 2.03
    Ensembl ID: ENSG00000117450
  • Gene Symbol: NCL (ENSG00000115053)
    Fold Change: 2.03
    Ensembl ID: ENSG00000115053
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 2.02
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.02
    Ensembl ID: ENSG00000169020
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.02
    Ensembl ID: ENSG00000172270
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 2.02
    Ensembl ID: ENSG00000153187
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.01
    Ensembl ID: ENSG00000154518
  • Gene Symbol: NDUFA1 (ENSG00000125356)
    Fold Change: 2.01
    Ensembl ID: ENSG00000125356

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in osteoblast cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in osteoblast cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Cell Type**: Osteoblasts are a type of bone-forming cell that plays a crucial role in the development and maintenance of the skeletal system. 2. **Function**: Osteoblasts are responsible for secreting osteoid, a non-mineralized matrix that is later mineralized to form bone tissue. 3. **Cellular Location**: Osteoblasts are located adjacent to or within osteoid tissue. 4. **Gene Symbol**: The gene symbol for osteoblasts is ACTB. 5. **Pathways/Ontology**: Osteoblasts are involved in various cellular processes, including actin cytoskeleton, adherens junction, cell-cell communication, and protein localization. 6. **Regulation**: Osteoblasts are regulated by various signaling pathways, including the MAPK signaling cascade and the PI3K/AKT signaling pathway. **Clinical Significance** 1. **Bone Disorders**: Osteoblasts play a crucial role in bone formation and maintenance. Dysregulation of osteoblast function can lead to bone disorders, such as osteoporosis, osteopenia, and bone cancer. 2. **Bone Tumors**: Osteoblasts are involved in the development of bone tumors, such as osteosarcoma and chondrosarcoma. 3. **Bone Metastasis**: Osteoblasts can contribute to the development of bone metastases, which are a common complication of various cancers. 4. **Bone Regeneration**: Osteoblasts play a crucial role in bone regeneration and repair. Understanding the mechanisms of osteoblast function and regulation can lead to the development of new therapies for bone disorders. 5. **Cancer Therapy**: Osteoblasts can be targeted for cancer therapy, as they are involved in the development and maintenance of bone metastases. In conclusion, osteoblasts are a crucial type of cell that plays a significant role in the development and maintenance of the skeletal system. Understanding their function, regulation, and clinical significance can lead to the development of new therapies for bone disorders and cancer.