Cell ID: CL0000091

Cell Name: Kupffer cell

CSI Thresholds:

Select	Context	Threshold
	Overall	9.1515
	Caudate lobe of liver + Healthy	106.8289
	Blastoma	35.5353
	Liver + Blastoma	35.5067
	Caudate lobe of liver	24.8905
	Primary biliary cholangitis	16.8694
	Caudate lobe of liver + Primary biliary cholangitis	16.8608
	Caudate lobe of liver + Primary sclerosing cholangitis	15.7852
	Primary sclerosing cholangitis	15.7207
	Liver + Healthy	9.8908
	Healthy	9.0381
	Spleen	7.9265
	Spleen + Healthy	7.9242
	Liver	7.3791
	Yolk sac	3.7133
	Yolk sac + Healthy	3.6971
	Skin of body	1.2949
	Skin of body + Healthy	1.2774

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system.

Synonyms: hepatic macrophage, littoral cell of hepatic sinusoid, liver macrophage, macrophagocytus stellatus, stellate cell of von Kupffer, von Kupffer cell