Details for: CL0000091
Cell ID: CL0000091
Cell Name: Kupffer cell
Marker Score Threshold: 1,000
(Derived using integrated single-cell and genomic data)
Description: A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system.
Synonyms: hepatic macrophage, littoral cell of hepatic sinusoid, liver macrophage, macrophagocytus stellatus, stellate cell of von Kupffer, von Kupffer cell
Genes (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Gene Symbol: GPX1 (ENSG00000233276)
Fold Change: 4.88
Ensembl ID: ENSG00000233276 - Gene Symbol: CTSD (ENSG00000117984)
Fold Change: 4.54
Ensembl ID: ENSG00000117984 - Gene Symbol: FOLR2 (ENSG00000165457)
Fold Change: 4.46
Ensembl ID: ENSG00000165457 - Gene Symbol: C1QC (ENSG00000159189)
Fold Change: 4.22
Ensembl ID: ENSG00000159189 - Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 4.11
Ensembl ID: ENSG00000124172 - Gene Symbol: CALM2 (ENSG00000143933)
Fold Change: 4.07
Ensembl ID: ENSG00000143933 - Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 3.99
Ensembl ID: ENSG00000135390 - Gene Symbol: CYBB (ENSG00000165168)
Fold Change: 3.65
Ensembl ID: ENSG00000165168 - Gene Symbol: CD5L (ENSG00000073754)
Fold Change: 3.53
Ensembl ID: ENSG00000073754 - Gene Symbol: FAU (ENSG00000149806)
Fold Change: 3.46
Ensembl ID: ENSG00000149806 - Gene Symbol: H3 3A (ENSG00000163041)
Fold Change: 3.42
Ensembl ID: ENSG00000163041 - Gene Symbol: COX8A (ENSG00000176340)
Fold Change: 3.4
Ensembl ID: ENSG00000176340 - Gene Symbol: CFL1 (ENSG00000172757)
Fold Change: 3.36
Ensembl ID: ENSG00000172757 - Gene Symbol: H3 3B (ENSG00000132475)
Fold Change: 3.36
Ensembl ID: ENSG00000132475 - Gene Symbol: CD63 (ENSG00000135404)
Fold Change: 3.34
Ensembl ID: ENSG00000135404 - Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 3.34
Ensembl ID: ENSG00000075624 - Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 3.33
Ensembl ID: ENSG00000149925 - Gene Symbol: EEF1A1 (ENSG00000156508)
Fold Change: 3.31
Ensembl ID: ENSG00000156508 - Gene Symbol: DAB2 (ENSG00000153071)
Fold Change: 3.31
Ensembl ID: ENSG00000153071 - Gene Symbol: FCER1G (ENSG00000158869)
Fold Change: 3.3
Ensembl ID: ENSG00000158869 - Gene Symbol: FYB1 (ENSG00000082074)
Fold Change: 3.29
Ensembl ID: ENSG00000082074 - Gene Symbol: CST3 (ENSG00000101439)
Fold Change: 3.29
Ensembl ID: ENSG00000101439 - Gene Symbol: COX4I1 (ENSG00000131143)
Fold Change: 3.28
Ensembl ID: ENSG00000131143 - Gene Symbol: COX7C (ENSG00000127184)
Fold Change: 3.27
Ensembl ID: ENSG00000127184 - Gene Symbol: AIF1 (ENSG00000204472)
Fold Change: 3.26
Ensembl ID: ENSG00000204472 - Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 3.25
Ensembl ID: ENSG00000145741 - Gene Symbol: CYBA (ENSG00000051523)
Fold Change: 3.25
Ensembl ID: ENSG00000051523 - Gene Symbol: B2M (ENSG00000166710)
Fold Change: 3.24
Ensembl ID: ENSG00000166710 - Gene Symbol: FTH1 (ENSG00000167996)
Fold Change: 3.22
Ensembl ID: ENSG00000167996 - Gene Symbol: HSP90AA1 (ENSG00000080824)
Fold Change: 3.22
Ensembl ID: ENSG00000080824 - Gene Symbol: FCGR3A (ENSG00000203747)
Fold Change: 3.22
Ensembl ID: ENSG00000203747 - Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 3.2
Ensembl ID: ENSG00000154518 - Gene Symbol: GAPDH (ENSG00000111640)
Fold Change: 3.19
Ensembl ID: ENSG00000111640 - Gene Symbol: FTL (ENSG00000087086)
Fold Change: 3.18
Ensembl ID: ENSG00000087086 - Gene Symbol: HLA C (ENSG00000204525)
Fold Change: 3.17
Ensembl ID: ENSG00000204525 - Gene Symbol: BLOC1S1 (ENSG00000135441)
Fold Change: 3.16
Ensembl ID: ENSG00000135441 - Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 3.16
Ensembl ID: ENSG00000241837 - Gene Symbol: CD74 (ENSG00000019582)
Fold Change: 3.12
Ensembl ID: ENSG00000019582 - Gene Symbol: FKBP1A (ENSG00000088832)
Fold Change: 3.12
Ensembl ID: ENSG00000088832 - Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 3.12
Ensembl ID: ENSG00000169100 - Gene Symbol: FOS (ENSG00000170345)
Fold Change: 3.11
Ensembl ID: ENSG00000170345 - Gene Symbol: HMGB1 (ENSG00000189403)
Fold Change: 3.11
Ensembl ID: ENSG00000189403 - Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 3.1
Ensembl ID: ENSG00000067560 - Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 3.1
Ensembl ID: ENSG00000099624 - Gene Symbol: EEF1B2 (ENSG00000114942)
Fold Change: 3.09
Ensembl ID: ENSG00000114942 - Gene Symbol: EEF1D (ENSG00000104529)
Fold Change: 3.08
Ensembl ID: ENSG00000104529 - Gene Symbol: HLA A (ENSG00000206503)
Fold Change: 3.07
Ensembl ID: ENSG00000206503 - Gene Symbol: HLA B (ENSG00000234745)
Fold Change: 3.06
Ensembl ID: ENSG00000234745 - Gene Symbol: COX6B1 (ENSG00000126267)
Fold Change: 3.06
Ensembl ID: ENSG00000126267 - Gene Symbol: GPR34 (ENSG00000171659)
Fold Change: 3.06
Ensembl ID: ENSG00000171659 - Gene Symbol: BLVRB (ENSG00000090013)
Fold Change: 3.05
Ensembl ID: ENSG00000090013 - Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 3.04
Ensembl ID: ENSG00000169020 - Gene Symbol: CTSB (ENSG00000164733)
Fold Change: 3.03
Ensembl ID: ENSG00000164733 - Gene Symbol: HLA E (ENSG00000204592)
Fold Change: 3.03
Ensembl ID: ENSG00000204592 - Gene Symbol: C1QB (ENSG00000173369)
Fold Change: 3.02
Ensembl ID: ENSG00000173369 - Gene Symbol: C1QA (ENSG00000173372)
Fold Change: 3.01
Ensembl ID: ENSG00000173372 - Gene Symbol: CTSS (ENSG00000163131)
Fold Change: 3.01
Ensembl ID: ENSG00000163131 - Gene Symbol: GRN (ENSG00000030582)
Fold Change: 3
Ensembl ID: ENSG00000030582 - Gene Symbol: HSPA8 (ENSG00000109971)
Fold Change: 3
Ensembl ID: ENSG00000109971 - Gene Symbol: HSP90AB1 (ENSG00000096384)
Fold Change: 2.99
Ensembl ID: ENSG00000096384 - Gene Symbol: COX6C (ENSG00000164919)
Fold Change: 2.99
Ensembl ID: ENSG00000164919 - Gene Symbol: FCGRT (ENSG00000104870)
Fold Change: 2.99
Ensembl ID: ENSG00000104870 - Gene Symbol: HNRNPA1 (ENSG00000135486)
Fold Change: 2.99
Ensembl ID: ENSG00000135486 - Gene Symbol: COX5B (ENSG00000135940)
Fold Change: 2.98
Ensembl ID: ENSG00000135940 - Gene Symbol: GPX4 (ENSG00000167468)
Fold Change: 2.97
Ensembl ID: ENSG00000167468 - Gene Symbol: CD68 (ENSG00000129226)
Fold Change: 2.97
Ensembl ID: ENSG00000129226 - Gene Symbol: GLUL (ENSG00000135821)
Fold Change: 2.96
Ensembl ID: ENSG00000135821 - Gene Symbol: DUSP1 (ENSG00000120129)
Fold Change: 2.96
Ensembl ID: ENSG00000120129 - Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 2.95
Ensembl ID: ENSG00000110955 - Gene Symbol: GSTP1 (ENSG00000084207)
Fold Change: 2.95
Ensembl ID: ENSG00000084207 - Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 2.94
Ensembl ID: ENSG00000184009 - Gene Symbol: HNRNPA2B1 (ENSG00000122566)
Fold Change: 2.94
Ensembl ID: ENSG00000122566 - Gene Symbol: CLIC1 (ENSG00000213719)
Fold Change: 2.93
Ensembl ID: ENSG00000213719 - Gene Symbol: ASAH1 (ENSG00000104763)
Fold Change: 2.93
Ensembl ID: ENSG00000104763 - Gene Symbol: ARHGDIB (ENSG00000111348)
Fold Change: 2.9
Ensembl ID: ENSG00000111348 - Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 2.9
Ensembl ID: ENSG00000154723 - Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 2.89
Ensembl ID: ENSG00000164111 - Gene Symbol: COX7A2 (ENSG00000112695)
Fold Change: 2.87
Ensembl ID: ENSG00000112695 - Gene Symbol: JUNB (ENSG00000171223)
Fold Change: 2.87
Ensembl ID: ENSG00000171223 - Gene Symbol: EEF2 (ENSG00000167658)
Fold Change: 2.86
Ensembl ID: ENSG00000167658 - Gene Symbol: CD14 (ENSG00000170458)
Fold Change: 2.84
Ensembl ID: ENSG00000170458 - Gene Symbol: CSTB (ENSG00000160213)
Fold Change: 2.81
Ensembl ID: ENSG00000160213 - Gene Symbol: AP2S1 (ENSG00000042753)
Fold Change: 2.81
Ensembl ID: ENSG00000042753 - Gene Symbol: HINT1 (ENSG00000169567)
Fold Change: 2.8
Ensembl ID: ENSG00000169567 - Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 2.79
Ensembl ID: ENSG00000117410 - Gene Symbol: CD86 (ENSG00000114013)
Fold Change: 2.77
Ensembl ID: ENSG00000114013 - Gene Symbol: COX6A1 (ENSG00000111775)
Fold Change: 2.75
Ensembl ID: ENSG00000111775 - Gene Symbol: GNG5 (ENSG00000174021)
Fold Change: 2.74
Ensembl ID: ENSG00000174021 - Gene Symbol: DDX5 (ENSG00000108654)
Fold Change: 2.74
Ensembl ID: ENSG00000108654 - Gene Symbol: KLF6 (ENSG00000067082)
Fold Change: 2.72
Ensembl ID: ENSG00000067082 - Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 2.71
Ensembl ID: ENSG00000005022 - Gene Symbol: CDC42 (ENSG00000070831)
Fold Change: 2.71
Ensembl ID: ENSG00000070831 - Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 2.7
Ensembl ID: ENSG00000198668 - Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 2.69
Ensembl ID: ENSG00000185650 - Gene Symbol: EIF3E (ENSG00000104408)
Fold Change: 2.69
Ensembl ID: ENSG00000104408 - Gene Symbol: CSF1R (ENSG00000182578)
Fold Change: 2.67
Ensembl ID: ENSG00000182578 - Gene Symbol: CLTA (ENSG00000122705)
Fold Change: 2.67
Ensembl ID: ENSG00000122705 - Gene Symbol: CTSC (ENSG00000109861)
Fold Change: 2.67
Ensembl ID: ENSG00000109861 - Gene Symbol: CFD (ENSG00000197766)
Fold Change: 2.67
Ensembl ID: ENSG00000197766 - Gene Symbol: ALB (ENSG00000163631)
Fold Change: 2.66
Ensembl ID: ENSG00000163631
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in Kupffer cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in Kupffer cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.