Details for: CL0000092

Cell ID: CL0000092

Cell Name: osteoclast

Marker Score Threshold: 498
(Derived using integrated single-cell and genomic data)

Description: A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.

Synonyms: chondroclast

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.15
    Ensembl ID: ENSG00000135390
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.15
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.12
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.09
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.05
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.04
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.01
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.01
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.99
    Ensembl ID: ENSG00000102575
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.99
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.97
    Ensembl ID: ENSG00000117410
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.97
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.96
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.94
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.92
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.91
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.87
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.85
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.83
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.83
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.82
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.81
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.8
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.79
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.76
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.75
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.74
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.72
    Ensembl ID: ENSG00000135046
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.71
    Ensembl ID: ENSG00000108561
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.68
    Ensembl ID: ENSG00000130208
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.68
    Ensembl ID: ENSG00000067560
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.67
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.67
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.67
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.65
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.59
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.59
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.59
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.56
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.56
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.53
    Ensembl ID: ENSG00000100412
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.51
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.51
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.5
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.48
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.47
    Ensembl ID: ENSG00000130203
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.46
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.45
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.44
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.43
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.43
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.41
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.41
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.39
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.37
    Ensembl ID: ENSG00000117054
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.35
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.35
    Ensembl ID: ENSG00000090013
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.34
    Ensembl ID: ENSG00000023445
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.34
    Ensembl ID: ENSG00000176171
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.33
    Ensembl ID: ENSG00000198356
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.32
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.31
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.3
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.29
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.29
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.28
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.25
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.24
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.23
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.22
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196975
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 1.21
    Ensembl ID: ENSG00000057657
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.19
    Ensembl ID: ENSG00000143153
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.19
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.19
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138279
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.17
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.15
    Ensembl ID: ENSG00000204574
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.15
    Ensembl ID: ENSG00000106605
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.14
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.13
    Ensembl ID: ENSG00000239900
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.13
    Ensembl ID: ENSG00000107262
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.09
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.09
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ALAS1 (ENSG00000023330)
    Fold Change: 1.08
    Ensembl ID: ENSG00000023330
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143322
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.06
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.05
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.05
    Ensembl ID: ENSG00000197894
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.02
    Ensembl ID: ENSG00000155366
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.01
    Ensembl ID: ENSG00000151729
  • Gene Symbol: NUDT2 (ENSG00000164978)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164978
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: N/A
    Ensembl ID: ENSG00000138363
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Specialized Phagocytic Cell**: Osteoclasts are a type of phagocytic cell that is specifically designed to remove mineralized bone tissue. 2. **Unique Markers**: Osteoclasts express a distinct set of markers, including tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive, and macrophage colony-stimulating factor 1 receptor-positive. 3. **Gene Symbol: ATP5MC2**: The osteoclast gene is represented by the symbol ATP5MC2, which is involved in various cellular processes, including cristae formation, mitochondrial biogenesis, and proton-transporting atp synthase complex activity. 4. **Synonyms: Chondroclast**: Osteoclasts are also referred to as chondroclasts, which is a term that refers to the removal of cartilage and bone tissue. 5. **Function**: Osteoclasts play a crucial role in bone remodeling and calcium homeostasis by removing mineralized bone tissue. **Clinical Significance** 1. **Bone Diseases**: Osteoclasts are involved in various bone diseases, including osteoporosis, bone cancer, and Paget's disease. 2. **Cancer Treatment**: Osteoclasts are being explored as a potential target for cancer treatment, as they can be used to deliver chemotherapy directly to cancer cells. 3. **Bone Regeneration**: Osteoclasts can be used to enhance bone regeneration by promoting the removal of mineralized bone tissue and promoting the growth of new bone tissue. 4. **Bone Cancer**: Osteoclasts are involved in the development of bone cancer, and understanding their function can provide insights into the development of new treatments for this disease. 5. **Osteoporosis Treatment**: Osteoclasts can be used to develop new treatments for osteoporosis, as they can be targeted to promote bone density and reduce the risk of fractures. In conclusion, osteoclasts are specialized phagocytic cells that play a crucial role in bone remodeling and calcium homeostasis. Understanding their function and characteristics can provide insights into the development of new treatments for various bone diseases, including osteoporosis and bone cancer.