Cell ID: CL0000092

Cell Name: osteoclast

CSI Thresholds:

Select	Context	Threshold
	Overall	10.2088
	Bone marrow + Healthy	11.2978
	Healthy	9.4632
	Bone marrow	6.4929
	Liver	5.8376
	Liver + Healthy	5.3308
	Skin of body + Healthy	0.8129
	Skin of body	0.7910
	Down syndrome	-4.6415
	Bone marrow + Down syndrome	-4.6467

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.

Synonyms: chondroclast