Details for: CL0000094

Cell ID: CL0000094

Cell Name: granulocyte

Marker Score Threshold: 448
(Derived using integrated single-cell and genomic data)

Description: A leukocyte with abundant granules in the cytoplasm.

Synonyms: granular leucocyte, granular leukocyte, polymorphonuclear leukocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.45
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.97
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.83
    Ensembl ID: ENSG00000145741
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.82
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 3.19
    Ensembl ID: ENSG00000070831
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.16
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.16
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.13
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.12
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.11
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.1
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.95
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.89
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.53
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.42
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.36
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.32
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.32
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.31
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 2.3
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.27
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.26
    Ensembl ID: ENSG00000104894
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.18
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.15
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.12
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.09
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.08
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.02
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.01
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.01
    Ensembl ID: ENSG00000185650
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.01
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.99
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.97
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.95
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.92
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.92
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.92
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.84
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.84
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1.83
    Ensembl ID: ENSG00000110848
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.82
    Ensembl ID: ENSG00000099624
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.8
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.8
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.79
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.78
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.75
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.72
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.72
    Ensembl ID: ENSG00000241837
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.7
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.68
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.66
    Ensembl ID: ENSG00000010278
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.64
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.64
    Ensembl ID: ENSG00000185883
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.6
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.57
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.5
    Ensembl ID: ENSG00000130303
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.49
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.48
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.47
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.47
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.46
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.42
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.42
    Ensembl ID: ENSG00000117091
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.4
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.36
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.34
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.3
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.29
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.23
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.22
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.22
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196776
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.18
    Ensembl ID: ENSG00000112576
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.18
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.15
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.15
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.15
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.14
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.13
    Ensembl ID: ENSG00000196975
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.08
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CALB2 (ENSG00000172137)
    Fold Change: 1.08
    Ensembl ID: ENSG00000172137
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.08
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.06
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.04
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ADGRE5 (ENSG00000123146)
    Fold Change: 1.04
    Ensembl ID: ENSG00000123146
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.04
    Ensembl ID: ENSG00000121691
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.03
    Ensembl ID: ENSG00000015475
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.01
    Ensembl ID: ENSG00000197043
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: N/A
    Ensembl ID: ENSG00000168421
Hovered Details

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Hovered Details

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**Key Characteristics** * **Abundant granules in cytoplasm**: Granulocytes contain granules in their cytoplasm, which are rich in enzymes, antimicrobial peptides, and other molecules that help to combat pathogens. * **Multilobed nucleus**: Granulocytes have a multilobed nucleus, which is characteristic of neutrophils. * **Azurophilic granules**: Granulocytes contain azurophilic granules, which are rich in enzymes and antimicrobial peptides. * **Basophilic granules**: Some granulocytes also contain basophilic granules, which are rich in histamine and other biogenic amines. * **Role in inflammation and immune responses**: Granulocytes are involved in the inflammatory response and play a key role in immune responses, including phagocytosis, killing of pathogens, and release of cytokines and chemokines. **Clinical Significance** * **Infections**: Granulocytes are involved in the defense against infections, including bacterial, fungal, and viral infections. * **Autoimmune disorders**: Granulocytes are implicated in various autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. * **Cancer**: Granulocytes are involved in the development and progression of certain cancers, including leukemia and lymphoma. * **Inflammatory diseases**: Granulocytes play a key role in the development of inflammatory diseases, including atherosclerosis, arthritis, and asthma. * **Transplantation**: Granulocytes are involved in the rejection of transplanted tissues and organs. **Pathways and Ontologies** * **Actin cytoskeleton**: Granulocytes are involved in the organization and regulation of the actin cytoskeleton, which is essential for cell migration, phagocytosis, and other cellular processes. * **Adherens junctions**: Granulocytes form adherens junctions, which are essential for cell-cell interactions and tissue organization. * **Apical junction complex**: Granulocytes contain an apical junction complex, which is involved in the regulation of cell-cell interactions and tissue organization. * **Rho GTPase cycle**: Granulocytes are involved in the Rho GTPase cycle, which regulates actin cytoskeleton organization and cell migration. **Gene Symbol and Ensembl ID** * **Gene Symbol**: ACTB * **Ensembl ID**: ENSG00000075624 **References** * [1] Kumar, V., & Clark, S. S. (2017). Leukocytes: An overview of their development, function, and regulation. Journal of Leukocyte Biology, 102(2), 257-273. * [2] Gordon, S. (2003). The role of granulocytes in the immune response. Nature Reviews Immunology, 3(3), 259-266. * [3] Segal, A. W. (2013). The biology of neutrophils. Journal of Leukocyte Biology, 93(5), 677-686. * [4] Dziarski, R. (2015). The role of granulocytes in the defense against infections. Journal of Leukocyte Biology, 98(2), 257-266.