Details for: CL0000100

Cell ID: CL0000100

Cell Name: motor neuron

Marker Score Threshold: 594
(Derived using integrated single-cell and genomic data)

Description: An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.

Synonyms: motoneuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.37
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.24
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.1
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 3.1
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.05
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.04
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.99
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.94
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.84
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.81
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.62
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.57
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.46
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.44
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.39
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.31
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.21
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.21
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.19
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 2.17
    Ensembl ID: ENSG00000139352
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.16
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.14
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.14
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.13
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.11
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.09
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2.08
    Ensembl ID: ENSG00000160014
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 2.08
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.08
    Ensembl ID: ENSG00000135404
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.07
    Ensembl ID: ENSG00000142192
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 2.07
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.06
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 2
    Ensembl ID: ENSG00000166165
  • Gene Symbol: CHRNA3 (ENSG00000080644)
    Fold Change: 1.97
    Ensembl ID: ENSG00000080644
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.95
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.93
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.91
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.9
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.85
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.84
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.84
    Ensembl ID: ENSG00000145362
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.8
    Ensembl ID: ENSG00000166710
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.78
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.74
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.74
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.73
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CHGA (ENSG00000100604)
    Fold Change: 1.71
    Ensembl ID: ENSG00000100604
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 1.7
    Ensembl ID: ENSG00000165462
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.69
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.66
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.65
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.56
    Ensembl ID: ENSG00000104765
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.54
    Ensembl ID: ENSG00000104964
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.52
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CHRNA7 (ENSG00000175344)
    Fold Change: 1.51
    Ensembl ID: ENSG00000175344
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.51
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.5
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.48
    Ensembl ID: ENSG00000153956
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.48
    Ensembl ID: ENSG00000138760
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.47
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.47
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.45
    Ensembl ID: ENSG00000198898
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.43
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143727
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.4
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.39
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.38
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.37
    Ensembl ID: ENSG00000177697
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.36
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.35
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.34
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.31
    Ensembl ID: ENSG00000111642
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.3
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.28
    Ensembl ID: ENSG00000185883
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.28
    Ensembl ID: ENSG00000085662
  • Gene Symbol: CDK4 (ENSG00000135446)
    Fold Change: 1.24
    Ensembl ID: ENSG00000135446
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.23
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CHD3 (ENSG00000170004)
    Fold Change: 1.22
    Ensembl ID: ENSG00000170004
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.22
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.21
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 1.18
    Ensembl ID: ENSG00000170558
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.16
    Ensembl ID: ENSG00000107262
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.16
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.15
    Ensembl ID: ENSG00000151746
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.15
    Ensembl ID: ENSG00000002330
  • Gene Symbol: CDKN1C (ENSG00000129757)
    Fold Change: 1.14
    Ensembl ID: ENSG00000129757
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.13
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.12
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.11
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.11
    Ensembl ID: ENSG00000164111
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.1
    Ensembl ID: ENSG00000151729
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.06
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.05
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CDKN1B (ENSG00000111276)
    Fold Change: 1.04
    Ensembl ID: ENSG00000111276
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.03
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.03
    Ensembl ID: ENSG00000096401
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Motor Neuron**: CL0000100 is a motor neuron, responsible for transmitting signals from the central nervous system to muscles, causing movement. 2. **Actin Cytoskeleton**: The cell is involved in actin cytoskeleton organization, which is essential for cell shape, movement, and intracellular transport. 3. **Adherens Junctions**: CL0000100 is characterized by its involvement in adherens junctions, which are critical for cell-cell communication and tissue structure. 4. **Axon Guidance**: The cell is involved in axon guidance, which is essential for the development and maintenance of the nervous system. 5. **Signaling Pathways**: CL0000100 is involved in various signaling pathways, including those related to growth factor receptors, second messengers, and Rho GTPases. 6. **Gene Expression**: The cell is associated with the gene symbol ACTB, which is involved in the regulation of gene expression, cell differentiation, and protein localization. **Clinical Significance** 1. **Neurological Disorders**: Motor neurons are involved in various neurological disorders, such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and Huntington's disease. 2. **Muscle Diseases**: CL0000100 is involved in muscle diseases, such as muscular dystrophy, which can lead to muscle weakness and wasting. 3. **Neurodevelopmental Disorders**: The cell is also involved in neurodevelopmental disorders, such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD). 4. **Cancer**: Motor neurons have been implicated in cancer, particularly in the development of glioblastoma, a type of brain cancer. 5. **Neuroinflammatory Diseases**: CL0000100 is involved in neuroinflammatory diseases, such as multiple sclerosis and Parkinson's disease. In conclusion, CL0000100 is a motor neuron that plays a crucial role in cell-cell communication, movement, and signaling pathways. Its involvement in various neurological disorders, muscle diseases, neurodevelopmental disorders, cancer, and neuroinflammatory diseases highlights its clinical significance. Further research is needed to understand the complex relationships between CL0000100 and these diseases.