Details for: CL0000103

Cell ID: CL0000103

Cell Name: bipolar neuron

Marker Score Threshold: 336
(Derived using integrated single-cell and genomic data)

Description: A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.45
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.37
    Ensembl ID: ENSG00000166710
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.81
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.78
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.77
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.76
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.65
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.59
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.58
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.42
    Ensembl ID: ENSG00000164919
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.31
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 2.3
    Ensembl ID: ENSG00000169862
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.29
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.25
    Ensembl ID: ENSG00000112695
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.24
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.22
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.2
    Ensembl ID: ENSG00000135940
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.13
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.13
    Ensembl ID: ENSG00000135404
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.1
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.09
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.01
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.96
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.95
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.94
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.87
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.86
    Ensembl ID: ENSG00000185650
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.85
    Ensembl ID: ENSG00000005022
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.8
    Ensembl ID: ENSG00000155368
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.76
    Ensembl ID: ENSG00000160213
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.73
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.7
    Ensembl ID: ENSG00000153113
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.64
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.63
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.61
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 1.59
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.59
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.56
    Ensembl ID: ENSG00000117410
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.56
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.54
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.54
    Ensembl ID: ENSG00000013441
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.53
    Ensembl ID: ENSG00000161203
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.52
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.49
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.48
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.47
    Ensembl ID: ENSG00000101439
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.45
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.44
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.43
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.43
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.43
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.42
    Ensembl ID: ENSG00000117984
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.36
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.35
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.34
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.32
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.3
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.29
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.27
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.24
    Ensembl ID: ENSG00000164733
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.23
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.22
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.21
    Ensembl ID: ENSG00000168036
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.21
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 1.2
    Ensembl ID: ENSG00000170558
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.2
    Ensembl ID: ENSG00000173575
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CYC1 (ENSG00000179091)
    Fold Change: 1.19
    Ensembl ID: ENSG00000179091
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.16
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.16
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.16
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.16
    Ensembl ID: ENSG00000004059
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.16
    Ensembl ID: ENSG00000105254
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.15
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.14
    Ensembl ID: ENSG00000160710
  • Gene Symbol: DDOST (ENSG00000244038)
    Fold Change: 1.14
    Ensembl ID: ENSG00000244038
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.13
    Ensembl ID: ENSG00000175416
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.12
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.1
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CDH11 (ENSG00000140937)
    Fold Change: 1.1
    Ensembl ID: ENSG00000140937
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.09
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.09
    Ensembl ID: ENSG00000141367
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.09
    Ensembl ID: ENSG00000074201
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.09
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.08
    Ensembl ID: ENSG00000148700
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 1.07
    Ensembl ID: ENSG00000173406
  • Gene Symbol: CSNK1D (ENSG00000141551)
    Fold Change: 1.07
    Ensembl ID: ENSG00000141551
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.06
    Ensembl ID: ENSG00000165995
  • Gene Symbol: CREM (ENSG00000095794)
    Fold Change: 1.05
    Ensembl ID: ENSG00000095794
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.03
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.03
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 1.03
    Ensembl ID: ENSG00000066032
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.01
    Ensembl ID: ENSG00000183255
  • Gene Symbol: COMT (ENSG00000093010)
    Fold Change: 1.01
    Ensembl ID: ENSG00000093010
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.01
    Ensembl ID: ENSG00000162909
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Type**: Bipolar neuron, a type of interneuron with two neurites (axon and dendrite) extending from opposite poles of an ovoid cell body. 2. **Genetic Information**: Encoded by the ACTB gene, which is involved in various cellular processes such as actin cytoskeleton organization, cell-cell junction formation, and protein localization. 3. **Signaling Pathways**: Diverse, including actin cytoskeleton, adherens junction, apical protein localization, ATP binding, axon guidance, axonogenesis, and others. 4. **Cell Motility**: Involvement in cell motility, including regulation of actin dynamics for phagocytic cup formation. 5. **Protein Localization**: Involvement in protein localization, including regulation of protein localization to adherens junction, plasma membrane, and others. 6. **Cell-Cell Junctions**: Involvement in cell-cell junction formation, including apical protein localization and adherens junction assembly. 7. **Cytoskeleton Organization**: Involvement in actin cytoskeleton organization, including regulation of actin dynamics for phagocytic cup formation. **Clinical Significance** 1. **Neurological Disorders**: Bipolar neurons are involved in various neurological disorders such as epilepsy, Parkinson's disease, and Alzheimer's disease. 2. **Neurodegenerative Diseases**: The dysfunction of bipolar neurons can lead to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Huntington's disease. 3. **Neurodevelopmental Disorders**: Bipolar neurons are involved in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. 4. **Neuroinflammation**: The dysregulation of bipolar neurons can lead to neuroinflammation, which is a hallmark of various neurological disorders. 5. **Therapeutic Targets**: The dysregulation of bipolar neurons can serve as a therapeutic target for the development of novel treatments for various neurological disorders. In conclusion, the bipolar neuron is a complex cell type involved in various cellular processes, including cell motility, protein localization, and cell-cell junction formation. The dysregulation of bipolar neurons can lead to various neurological disorders, making them a potential therapeutic target for the development of novel treatments.