Details for: CL0000120

Cell ID: CL0000120

Cell Name: granule cell

Marker Score Threshold: 7540
(Derived using integrated single-cell and genomic data)

Description: A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 8.77
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 8.52
    Ensembl ID: ENSG00000018236
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 8.34
    Ensembl ID: ENSG00000169862
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 8
    Ensembl ID: ENSG00000145362
  • Gene Symbol: DSCAM (ENSG00000171587)
    Fold Change: 7.99
    Ensembl ID: ENSG00000171587
  • Gene Symbol: DPP6 (ENSG00000130226)
    Fold Change: 7.74
    Ensembl ID: ENSG00000130226
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 7.56
    Ensembl ID: ENSG00000066032
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 7.48
    Ensembl ID: ENSG00000079102
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 7.37
    Ensembl ID: ENSG00000154162
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 7.19
    Ensembl ID: ENSG00000145526
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 6.89
    Ensembl ID: ENSG00000153956
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 5.39
    Ensembl ID: ENSG00000088538
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 5.37
    Ensembl ID: ENSG00000084234
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 5.17
    Ensembl ID: ENSG00000142599
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 5.09
    Ensembl ID: ENSG00000184349
  • Gene Symbol: CDH7 (ENSG00000081138)
    Fold Change: 4.79
    Ensembl ID: ENSG00000081138
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 4.79
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 4.77
    Ensembl ID: ENSG00000257923
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 4.32
    Ensembl ID: ENSG00000150672
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 4.26
    Ensembl ID: ENSG00000134982
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 4.06
    Ensembl ID: ENSG00000170558
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 4.01
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.96
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 3.95
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CPE (ENSG00000109472)
    Fold Change: 3.94
    Ensembl ID: ENSG00000109472
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 3.77
    Ensembl ID: ENSG00000204217
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 3.59
    Ensembl ID: ENSG00000092964
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 3.57
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 3.44
    Ensembl ID: ENSG00000170017
  • Gene Symbol: CBLN1 (ENSG00000102924)
    Fold Change: 3.42
    Ensembl ID: ENSG00000102924
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 3.37
    Ensembl ID: ENSG00000141837
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.3
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CHRM3 (ENSG00000133019)
    Fold Change: 3.26
    Ensembl ID: ENSG00000133019
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 3.2
    Ensembl ID: ENSG00000151067
  • Gene Symbol: DCX (ENSG00000077279)
    Fold Change: 3.14
    Ensembl ID: ENSG00000077279
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 2.94
    Ensembl ID: ENSG00000134769
  • Gene Symbol: BRINP1 (ENSG00000078725)
    Fold Change: 2.8
    Ensembl ID: ENSG00000078725
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.72
    Ensembl ID: ENSG00000053254
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 2.69
    Ensembl ID: ENSG00000138760
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 2.68
    Ensembl ID: ENSG00000173406
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 2.65
    Ensembl ID: ENSG00000148408
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 2.63
    Ensembl ID: ENSG00000034053
  • Gene Symbol: CRMP1 (ENSG00000072832)
    Fold Change: 2.58
    Ensembl ID: ENSG00000072832
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.57
    Ensembl ID: ENSG00000157764
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.55
    Ensembl ID: ENSG00000163697
  • Gene Symbol: DPYSL3 (ENSG00000113657)
    Fold Change: 2.37
    Ensembl ID: ENSG00000113657
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 2.23
    Ensembl ID: ENSG00000107282
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.23
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ELAVL2 (ENSG00000107105)
    Fold Change: 2.16
    Ensembl ID: ENSG00000107105
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.15
    Ensembl ID: ENSG00000108684
  • Gene Symbol: CNR1 (ENSG00000118432)
    Fold Change: 2.01
    Ensembl ID: ENSG00000118432
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 1.92
    Ensembl ID: ENSG00000198947
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.86
    Ensembl ID: ENSG00000152092
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1.84
    Ensembl ID: ENSG00000066382
  • Gene Symbol: CAMK4 (ENSG00000152495)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152495
  • Gene Symbol: DTNB (ENSG00000138101)
    Fold Change: 1.75
    Ensembl ID: ENSG00000138101
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.74
    Ensembl ID: ENSG00000155897
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.74
    Ensembl ID: ENSG00000132964
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.69
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.64
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.64
    Ensembl ID: ENSG00000164742
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 1.62
    Ensembl ID: ENSG00000198216
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.54
    Ensembl ID: ENSG00000198589
  • Gene Symbol: MEGF9 (ENSG00000106780)
    Fold Change: 1.53
    Ensembl ID: ENSG00000106780
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.53
    Ensembl ID: ENSG00000197102
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.51
    Ensembl ID: ENSG00000114423
  • Gene Symbol: DYRK1A (ENSG00000157540)
    Fold Change: 1.5
    Ensembl ID: ENSG00000157540
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.5
    Ensembl ID: ENSG00000182389
  • Gene Symbol: CREBBP (ENSG00000005339)
    Fold Change: 1.48
    Ensembl ID: ENSG00000005339
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 1.44
    Ensembl ID: ENSG00000106976
  • Gene Symbol: CLCN3 (ENSG00000109572)
    Fold Change: 1.42
    Ensembl ID: ENSG00000109572
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143322
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.33
    Ensembl ID: ENSG00000145349
  • Gene Symbol: DYNC1I2 (ENSG00000077380)
    Fold Change: 1.29
    Ensembl ID: ENSG00000077380
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.28
    Ensembl ID: ENSG00000078053
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.28
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.26
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.25
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.25
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.23
    Ensembl ID: ENSG00000162104
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.22
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.21
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.21
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.19
    Ensembl ID: ENSG00000141367
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.18
    Ensembl ID: ENSG00000006125
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.17
    Ensembl ID: ENSG00000107779
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.16
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CREB1 (ENSG00000118260)
    Fold Change: 1.16
    Ensembl ID: ENSG00000118260
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.13
    Ensembl ID: ENSG00000097007
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.13
    Ensembl ID: ENSG00000113712
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.12
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.11
    Ensembl ID: ENSG00000168036
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.1
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.1
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: 1.1
    Ensembl ID: ENSG00000121989
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.07
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.03
    Ensembl ID: ENSG00000137486
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 1.02
    Ensembl ID: ENSG00000166165
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.01
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.01
    Ensembl ID: ENSG00000183044
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell Type**: Granule cells are a type of neuron found in the vertebrate central nervous system. * **Location**: Granule cells are primarily located in the granular layer of the cerebellar cortex, cerebral cortex, and olfactory bulb. * **Size**: Granule cells are small in size. * **Function**: Granule cells play a crucial role in the development and function of the nervous system. * **Genes**: The genes associated with granule cells are ANK3, CNTN1, and CTNND2, which are involved in various cellular processes such as cell adhesion, signaling, and protein trafficking. **Clinical Significance** * **Neurological Disorders**: Dysregulation of granule cells has been implicated in various neurological disorders such as autism, schizophrenia, and cerebellar ataxia. * **Developmental Delays**: Granule cell dysfunction has been linked to developmental delays and learning disabilities. * **Neurodegenerative Diseases**: Granule cell dysfunction has also been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. * **Therapeutic Strategies**: Understanding the function and regulation of granule cells is essential for the development of novel therapeutic strategies for neurological diseases. **Pathways and Ontology** * **Asparagine N-linked Glycosylation**: Granule cells are involved in the regulation of asparagine N-linked glycosylation, which is essential for protein function and cell-cell adhesion. * **Axon Guidance**: Granule cells play a crucial role in axon guidance, which is essential for the development and function of the nervous system. * **Cell Surface**: Granule cells are involved in the regulation of cell surface proteins, which are essential for cell-cell adhesion and signaling. * **Cytoskeleton Organization**: Granule cells are involved in the regulation of cytoskeleton organization, which is essential for cell shape and function. * **Gene Expression**: Granule cells are involved in the regulation of gene expression, which is essential for the development and function of the nervous system. **Protein Interactions** * **ANK2**: Granule cells interact with ANK2, which is involved in the regulation of cell surface proteins and signaling. * **CNTN1**: Granule cells interact with CNTN1, which is involved in the regulation of axon guidance and cell-cell adhesion. * **CTNND2**: Granule cells interact with CTNND2, which is involved in the regulation of cell-cell adhesion and signaling. **Cellular Processes** * **Cell Adhesion**: Granule cells are involved in the regulation of cell adhesion, which is essential for cell-cell interactions and signaling. * **Signaling**: Granule cells are involved in the regulation of signaling, which is essential for cell-cell interactions and development. * **Protein Trafficking**: Granule cells are involved in the regulation of protein trafficking, which is essential for protein function and cell-cell adhesion. **Regulation and Modulation** * **Regulation of Gene Expression**: Granule cells are involved in the regulation of gene expression, which is essential for the development and function of the nervous system. * **Regulation of Cell Surface Proteins**: Granule cells are involved in the regulation of cell surface proteins, which are essential for cell-cell adhesion and signaling. * **Regulation of Cytoskeleton Organization**: Granule cells are involved in the regulation of cytoskeleton organization, which is essential for cell shape and function. In conclusion, granule cells are a type of neuron found in the vertebrate central nervous system, and their dysregulation has been implicated in various neurological disorders. Understanding the function and regulation of granule cells is essential for the development of novel therapeutic strategies for neurological diseases.