CL0000126 - macroglial cell details

Details for: CL0000126

Cell ID: CL0000126

Cell Name: macroglial cell

Marker Score Threshold: 2299
(Derived using integrated single-cell and genomic data)

Description: A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together.

Synonyms: macrogliocyte, macroglia

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: DSCAM (ENSG00000171587)
Fold Change: 7.55
Ensembl ID: ENSG00000171587
Gene Symbol: CNTN1 (ENSG00000018236)
Fold Change: 7.25
Ensembl ID: ENSG00000018236
Gene Symbol: ANK3 (ENSG00000151150)
Fold Change: 7.17
Ensembl ID: ENSG00000151150
Gene Symbol: ANK2 (ENSG00000145362)
Fold Change: 7.15
Ensembl ID: ENSG00000145362
Gene Symbol: CDH12 (ENSG00000154162)
Fold Change: 7.03
Ensembl ID: ENSG00000154162
Gene Symbol: DPP6 (ENSG00000130226)
Fold Change: 6.96
Ensembl ID: ENSG00000130226
Gene Symbol: CTNNA2 (ENSG00000066032)
Fold Change: 6.76
Ensembl ID: ENSG00000066032
Gene Symbol: RUNX1T1 (ENSG00000079102)
Fold Change: 6.55
Ensembl ID: ENSG00000079102
Gene Symbol: CTNND2 (ENSG00000169862)
Fold Change: 6.3
Ensembl ID: ENSG00000169862
Gene Symbol: CACNA2D1 (ENSG00000153956)
Fold Change: 5.79
Ensembl ID: ENSG00000153956
Gene Symbol: DOCK3 (ENSG00000088538)
Fold Change: 5.02
Ensembl ID: ENSG00000088538
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 4.76
Ensembl ID: ENSG00000084234
Gene Symbol: CUX1 (ENSG00000257923)
Fold Change: 4.59
Ensembl ID: ENSG00000257923
Gene Symbol: RERE (ENSG00000142599)
Fold Change: 4.22
Ensembl ID: ENSG00000142599
Gene Symbol: CPE (ENSG00000109472)
Fold Change: 4.21
Ensembl ID: ENSG00000109472
Gene Symbol: DLG2 (ENSG00000150672)
Fold Change: 4.17
Ensembl ID: ENSG00000150672
Gene Symbol: APP (ENSG00000142192)
Fold Change: 4.07
Ensembl ID: ENSG00000142192
Gene Symbol: ASIC2 (ENSG00000108684)
Fold Change: 4.03
Ensembl ID: ENSG00000108684
Gene Symbol: CACNA1A (ENSG00000141837)
Fold Change: 3.79
Ensembl ID: ENSG00000141837
Gene Symbol: BRINP1 (ENSG00000078725)
Fold Change: 3.52
Ensembl ID: ENSG00000078725
Gene Symbol: CACNA1C (ENSG00000151067)
Fold Change: 3.51
Ensembl ID: ENSG00000151067
Gene Symbol: BMPR2 (ENSG00000204217)
Fold Change: 3.44
Ensembl ID: ENSG00000204217
Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 3.43
Ensembl ID: ENSG00000198668
Gene Symbol: CDH8 (ENSG00000150394)
Fold Change: 3.42
Ensembl ID: ENSG00000150394
Gene Symbol: CHRM3 (ENSG00000133019)
Fold Change: 3.37
Ensembl ID: ENSG00000133019
Gene Symbol: CBLN1 (ENSG00000102924)
Fold Change: 3.33
Ensembl ID: ENSG00000102924
Gene Symbol: CDH7 (ENSG00000081138)
Fold Change: 3.29
Ensembl ID: ENSG00000081138
Gene Symbol: DPYSL2 (ENSG00000092964)
Fold Change: 3.13
Ensembl ID: ENSG00000092964
Gene Symbol: CACNA1B (ENSG00000148408)
Fold Change: 3.06
Ensembl ID: ENSG00000148408
Gene Symbol: DST (ENSG00000151914)
Fold Change: 3.04
Ensembl ID: ENSG00000151914
Gene Symbol: APC (ENSG00000134982)
Fold Change: 2.99
Ensembl ID: ENSG00000134982
Gene Symbol: CDH2 (ENSG00000170558)
Fold Change: 2.94
Ensembl ID: ENSG00000170558
Gene Symbol: ADCY8 (ENSG00000155897)
Fold Change: 2.85
Ensembl ID: ENSG00000155897
Gene Symbol: ALCAM (ENSG00000170017)
Fold Change: 2.81
Ensembl ID: ENSG00000170017
Gene Symbol: DCX (ENSG00000077279)
Fold Change: 2.72
Ensembl ID: ENSG00000077279
Gene Symbol: BICD1 (ENSG00000151746)
Fold Change: 2.64
Ensembl ID: ENSG00000151746
Gene Symbol: FOXN3 (ENSG00000053254)
Fold Change: 2.59
Ensembl ID: ENSG00000053254
Gene Symbol: APBA1 (ENSG00000107282)
Fold Change: 2.48
Ensembl ID: ENSG00000107282
Gene Symbol: BMP5 (ENSG00000112175)
Fold Change: 2.48
Ensembl ID: ENSG00000112175
Gene Symbol: BRAF (ENSG00000157764)
Fold Change: 2.44
Ensembl ID: ENSG00000157764
Gene Symbol: LDLRAD4 (ENSG00000168675)
Fold Change: 2.41
Ensembl ID: ENSG00000168675
Gene Symbol: CNR1 (ENSG00000118432)
Fold Change: 2.4
Ensembl ID: ENSG00000118432
Gene Symbol: APBB2 (ENSG00000163697)
Fold Change: 2.36
Ensembl ID: ENSG00000163697
Gene Symbol: ASTN1 (ENSG00000152092)
Fold Change: 2.25
Ensembl ID: ENSG00000152092
Gene Symbol: SCARB2 (ENSG00000138760)
Fold Change: 2.24
Ensembl ID: ENSG00000138760
Gene Symbol: APBA2 (ENSG00000034053)
Fold Change: 2.15
Ensembl ID: ENSG00000034053
Gene Symbol: ATP2B1 (ENSG00000070961)
Fold Change: 2.14
Ensembl ID: ENSG00000070961
Gene Symbol: CACNA1E (ENSG00000198216)
Fold Change: 2.1
Ensembl ID: ENSG00000198216
Gene Symbol: CAMK4 (ENSG00000152495)
Fold Change: 2.05
Ensembl ID: ENSG00000152495
Gene Symbol: DPYSL3 (ENSG00000113657)
Fold Change: 2.04
Ensembl ID: ENSG00000113657
Gene Symbol: CACNB4 (ENSG00000182389)
Fold Change: 2.03
Ensembl ID: ENSG00000182389
Gene Symbol: CRMP1 (ENSG00000072832)
Fold Change: 1.99
Ensembl ID: ENSG00000072832
Gene Symbol: CD47 (ENSG00000196776)
Fold Change: 1.9
Ensembl ID: ENSG00000196776
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 1.9
Ensembl ID: ENSG00000184009
Gene Symbol: CDK8 (ENSG00000132964)
Fold Change: 1.73
Ensembl ID: ENSG00000132964
Gene Symbol: CRYAB (ENSG00000109846)
Fold Change: 1.71
Ensembl ID: ENSG00000109846
Gene Symbol: ADK (ENSG00000156110)
Fold Change: 1.7
Ensembl ID: ENSG00000156110
Gene Symbol: DNM1 (ENSG00000106976)
Fold Change: 1.63
Ensembl ID: ENSG00000106976
Gene Symbol: APLP1 (ENSG00000105290)
Fold Change: 1.63
Ensembl ID: ENSG00000105290
Gene Symbol: LRBA (ENSG00000198589)
Fold Change: 1.58
Ensembl ID: ENSG00000198589
Gene Symbol: ADCY9 (ENSG00000162104)
Fold Change: 1.57
Ensembl ID: ENSG00000162104
Gene Symbol: AMPH (ENSG00000078053)
Fold Change: 1.55
Ensembl ID: ENSG00000078053
Gene Symbol: DAB1 (ENSG00000173406)
Fold Change: 1.55
Ensembl ID: ENSG00000173406
Gene Symbol: CLCN3 (ENSG00000109572)
Fold Change: 1.48
Ensembl ID: ENSG00000109572
Gene Symbol: CDH18 (ENSG00000145526)
Fold Change: 1.47
Ensembl ID: ENSG00000145526
Gene Symbol: CREBBP (ENSG00000005339)
Fold Change: 1.45
Ensembl ID: ENSG00000005339
Gene Symbol: DMD (ENSG00000198947)
Fold Change: 1.44
Ensembl ID: ENSG00000198947
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 1.42
Ensembl ID: ENSG00000075624
Gene Symbol: ASPH (ENSG00000198363)
Fold Change: 1.4
Ensembl ID: ENSG00000198363
Gene Symbol: CALM2 (ENSG00000143933)
Fold Change: 1.37
Ensembl ID: ENSG00000143933
Gene Symbol: DYNC1H1 (ENSG00000197102)
Fold Change: 1.35
Ensembl ID: ENSG00000197102
Gene Symbol: CDH11 (ENSG00000140937)
Fold Change: 1.32
Ensembl ID: ENSG00000140937
Gene Symbol: ABL2 (ENSG00000143322)
Fold Change: 1.31
Ensembl ID: ENSG00000143322
Gene Symbol: CBLB (ENSG00000114423)
Fold Change: 1.31
Ensembl ID: ENSG00000114423
Gene Symbol: CAMK2D (ENSG00000145349)
Fold Change: 1.3
Ensembl ID: ENSG00000145349
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 1.3
Ensembl ID: ENSG00000124172
Gene Symbol: BMPR1A (ENSG00000107779)
Fold Change: 1.26
Ensembl ID: ENSG00000107779
Gene Symbol: DDX5 (ENSG00000108654)
Fold Change: 1.23
Ensembl ID: ENSG00000108654
Gene Symbol: KIF1A (ENSG00000130294)
Fold Change: 1.22
Ensembl ID: ENSG00000130294
Gene Symbol: CD81 (ENSG00000110651)
Fold Change: 1.22
Ensembl ID: ENSG00000110651
Gene Symbol: ACYP2 (ENSG00000170634)
Fold Change: 1.21
Ensembl ID: ENSG00000170634
Gene Symbol: CFL1 (ENSG00000172757)
Fold Change: 1.17
Ensembl ID: ENSG00000172757
Gene Symbol: ATP2A2 (ENSG00000174437)
Fold Change: 1.17
Ensembl ID: ENSG00000174437
Gene Symbol: DYNC1I2 (ENSG00000077380)
Fold Change: 1.16
Ensembl ID: ENSG00000077380
Gene Symbol: CXADR (ENSG00000154639)
Fold Change: 1.13
Ensembl ID: ENSG00000154639
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 1.12
Ensembl ID: ENSG00000135390
Gene Symbol: CREB1 (ENSG00000118260)
Fold Change: 1.1
Ensembl ID: ENSG00000118260
Gene Symbol: CSNK1A1 (ENSG00000113712)
Fold Change: 1.1
Ensembl ID: ENSG00000113712
Gene Symbol: AP2B1 (ENSG00000006125)
Fold Change: 1.1
Ensembl ID: ENSG00000006125
Gene Symbol: ADCY1 (ENSG00000164742)
Fold Change: 1.1
Ensembl ID: ENSG00000164742
Gene Symbol: CTNNB1 (ENSG00000168036)
Fold Change: 1.08
Ensembl ID: ENSG00000168036
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 1.07
Ensembl ID: ENSG00000154723
Gene Symbol: BCKDHB (ENSG00000083123)
Fold Change: 1.06
Ensembl ID: ENSG00000083123
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.05
Ensembl ID: ENSG00000172270
Gene Symbol: ADD1 (ENSG00000087274)
Fold Change: 1.05
Ensembl ID: ENSG00000087274
Gene Symbol: CHD2 (ENSG00000173575)
Fold Change: 1.05
Ensembl ID: ENSG00000173575
Gene Symbol: ABL1 (ENSG00000097007)
Fold Change: 1.04
Ensembl ID: ENSG00000097007
Gene Symbol: ABCA3 (ENSG00000167972)
Fold Change: 1.03
Ensembl ID: ENSG00000167972
Gene Symbol: DMXL1 (ENSG00000172869)
Fold Change: 1.01
Ensembl ID: ENSG00000172869
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 1
Ensembl ID: ENSG00000169020

Gene representation (1276)
Gene/Pathway representation (1276)

Hovered Details

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**Key Characteristics** * Ectodermal origin: Macrogliocytes are derived from ectodermal cells, which are the precursors to the nervous system. * Composition: Macrogliocytes are composed of astrocytes and oligodendrocytes, which are distinct types of neuroglial cells. * Functions: Macrogliocytes provide support and maintenance functions to neurons, including cell-cell adhesion, axon guidance, and synaptic function. * Pathways and Ontology: Macrogliocytes are involved in various cellular processes, including cell-cell adhesion, axon guidance, and synaptic function. They are also involved in the development and maintenance of the CNS, including the formation of synapses and the organization of the cytoskeleton. * Genes: Macrogliocytes are associated with several genes, including DSCAM, CNTN1, ANK3, and CDH12. **Clinical Significance** * Neurological disorders: Macrogliocytes play a crucial role in the development and maintenance of the CNS, and abnormalities in their function can contribute to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. * Cancer: Macrogliocytes have been implicated in the development and progression of certain types of cancer, including glioblastoma and medulloblastoma. * Neurodevelopmental disorders: Abnormalities in macrogliocyte function have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. * Neuroregeneration: Macrogliocytes have the potential to contribute to neuroregeneration and repair, and their study may provide insights into the development of novel therapeutic strategies for neurological disorders. **Cell ID: CL0000126** * Gene Symbol: DSCAM * Ensembl ID: ENSG00000171587 * Pathways/Ontology: Axon guidance, Camera-type eye photoreceptor cell differentiation, Cell-cell adhesion mediator activity, Cell adhesion, Central nervous system development, Dendrite, Dendrite morphogenesis, Dendrite self-avoidance, Developmental biology, Dscam interactions, Extracellular region, Growth cone, Homophilic cell adhesion via plasma membrane adhesion molecules, Locomotory behavior, Membrane, Negative regulation of cell adhesion, Nervous system development, Netrin-1 signaling, Netrin-activated signaling pathway, Netrin receptor binding, Neuronal cell body, Plasma membrane, Positive regulation of axon extension involved in axon guidance, Positive regulation of phosphorylation, Post-embryonic retina morphogenesis in camera-type eye, Protein binding, Protein tyrosine kinase binding, Retina layer formation, Synapse, Synapse assembly **Cell ID: CL0000127** * Gene Symbol: CNTN1 * Ensembl ID: ENSG00000018236 * Pathways/Ontology: Activated notch1 transmits signal to the nucleus, Axon, Axon guidance, Brain development, Carbohydrate binding, Cell-cell adhesion, Cell-cell adhesion mediator activity, Cell adhesion, Central nervous system myelin formation, Cerebellum development, Developmental biology, Extracellular exosome, Gene expression, L1cam interactions, Locomotory behavior, Membrane, Nervous system development, Neurofascin interactions, Notch2 activation and transmission of signal to the nucleus, Notch signaling pathway, Plasma membrane, Positive regulation of gene expression, Positive regulation of neuron projection development, Positive regulation of sodium ion transport, Postsynaptic membrane, Presynaptic membrane, Protein binding, Side of membrane, Signaling by notch, Signaling by notch1, Signaling by notch2, Signal transduction **Cell ID: CL0000128** * Gene Symbol: ANK3 * Ensembl ID: ENSG00000151150 * Pathways/Ontology: Asparagine n-linked glycosylation, Axon guidance, Axon initial segment, Axonogenesis, Basal plasma membrane, Basolateral plasma membrane, Bicellular tight junction, Cadherin binding, Cell surface, Cellular response to magnesium ion, Copi-mediated anterograde transport, Costamere, Cytoskeletal anchor activity, Cytoskeletal protein binding, Cytoskeleton organization, Cytosol, Dendrite, Developmental biology, Endoplasmic reticulum, Er to golgi anterograde transport, Establishment of protein localization, Golgi apparatus, Golgi to plasma membrane protein transport, Interaction between l1 and ankyrins, Intercalated disc, L1cam interactions, Lateral plasma membrane, Lysosome, Magnesium ion homeostasis, Maintenance of protein location in plasma membrane, Membrane assembly, Membrane trafficking, Metabolism of proteins, Mitotic cytokinesis, Negative regulation of delayed rectifier potassium channel activity, Nervous system development, Neuromuscular junction, Neuromuscular junction development, Neuronal action potential, Neuron projection, Node of ranvier, Plasma membrane, Plasma membrane organization, Positive regulation of cation channel activity, Positive regulation of cell communication by electrical coupling, Positive regulation of gene expression, Positive regulation of homotypic cell-cell adhesion, Positive regulation of membrane depolarization during cardiac muscle cell action potential, Positive regulation of membrane potential, Positive regulation of protein targeting to membrane, Positive regulation of sodium ion transmembrane transporter activity, Positive regulation of sodium ion transport, Post-translational protein modification, Postsynaptic membrane, Protein-macromolecule adaptor activity, Protein binding, Protein localization to axon, Protein localization to plasma membrane, Regulation of potassium ion transport, Sarcolemma, Sarcoplasmic reticulum, Signal transduction, Spectrin-associated cytoskeleton, Spectrin binding, Structural constituent of cytoskeleton, T-tubule, Transmembrane transporter binding, Transport to the golgi and subsequent modification, Vesicle-mediated transport, Z disc **Cell ID: CL0000129** * Gene Symbol: ANK2 * Ensembl ID: ENSG00000145362 * Pathways/Ontology: A band, Apical plasma membrane, Asparagine n-linked glycosylation, Atpase binding, Atrial cardiac muscle cell action potential, Atrial cardiac muscle cell to av node cell communication, Atrial septum development, Axon guidance, Basolateral plasma membrane, Copi-mediated anterograde transport, Costamere, Cytoskeletal anchor activity, Cytoskeleton, Cytoskeleton organization, Cytosol, Developmental biology, Early endosome, Endocytosis, Enzyme binding, Er to golgi anterograde transport, Interaction between l1 and ankyrins, Intercalated disc, Intracellular calcium ion homeostasis, L1cam interactions, Lysosome, M band, Membrane depolarization during sa node cell action potential, Membrane trafficking, Metabolism of proteins, Mitochondrion, Nervous system development, Neuron projection, Paranodal junction assembly, Phosphorylation-dependent protein binding, Plasma membrane, Positive regulation of calcium ion transmembrane transporter activity, Positive regulation of calcium ion transport, Positive regulation of cation channel activity, Positive regulation of gene expression, Positive regulation of potassium ion transmembrane transporter activity, Positive regulation of potassium ion transport, Post-translational protein modification, Postsynaptic membrane, Protein-macromolecule adaptor activity, Protein binding, Protein kinase binding, Protein localization, Protein localization to cell surface, Protein localization to endoplasmic reticulum, Protein localization to m-band, Protein localization to organelle, Protein localization to plasma membrane, Protein localization to t-tubule, Protein stabilization, Protein transport, Recycling endosome, Regulation of atrial cardiac muscle cell action potential, Regulation of calcium ion transmembrane transporter activity, Regulation of calcium ion transport, Regulation of cardiac muscle cell contraction, Regulation of cardiac muscle contraction, Regulation of cardiac muscle contraction by calcium ion signaling, Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, Regulation of heart rate, Regulation of heart rate by cardiac conduction, Regulation of protein stability, Regulation of release of sequestered calcium ion into cytosol, Regulation of sa node cell action potential, Regulation of ventricular cardiac muscle cell membrane repolarization, Response to methylmercury, Sa node cell action potential, Sa node cell to atrial cardiac muscle cell communication, Sarcolemma, Sarcoplasmic reticulum calcium ion transport, Spectrin binding, Structural constituent of cytoskeleton, T-tubule, T-tubule organization, Transmembrane transporter binding, Transport to the golgi and subsequent modification, Ventricular cardiac muscle cell action potential, Vesicle-mediated transport, Z disc **Cell ID: CL0000130** * Gene Symbol: CDH12 * Ensembl ID: ENSG00000154162 * Pathways/Ontology: Adherens junction, Adherens junction organization, Adherens junctions interactions, Cadherin binding, Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, Calcium ion binding, Catenin complex, Cell-cell adhesion mediated by cadherin, Cell-cell communication, Cell-cell junction assembly,

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.