Details for: CL0000132

Cell ID: CL0000132

Cell Name: corneal endothelial cell

Marker Score Threshold: 583
(Derived using integrated single-cell and genomic data)

Description: An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 3.13
    Ensembl ID: ENSG00000140836
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.13
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CA12 (ENSG00000074410)
    Fold Change: 3.09
    Ensembl ID: ENSG00000074410
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 3.07
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 3
    Ensembl ID: ENSG00000170017
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 2.74
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 2.68
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.67
    Ensembl ID: ENSG00000198363
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.47
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.38
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.38
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.36
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.33
    Ensembl ID: ENSG00000163399
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.31
    Ensembl ID: ENSG00000151914
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.24
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.15
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 2.13
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 2.09
    Ensembl ID: ENSG00000097007
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.08
    Ensembl ID: ENSG00000157764
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 2.07
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 2.07
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 2.07
    Ensembl ID: ENSG00000078295
  • Gene Symbol: CA3 (ENSG00000164879)
    Fold Change: 2.05
    Ensembl ID: ENSG00000164879
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 2.04
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.98
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.98
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.96
    Ensembl ID: ENSG00000078549
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 1.95
    Ensembl ID: ENSG00000083123
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.9
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.88
    Ensembl ID: ENSG00000175054
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.88
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.86
    Ensembl ID: ENSG00000100412
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.85
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.83
    Ensembl ID: ENSG00000110955
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.81
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 1.78
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.77
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.7
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.7
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.7
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.69
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.68
    Ensembl ID: ENSG00000185650
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.67
    Ensembl ID: ENSG00000148090
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.65
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.64
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AP1G1 (ENSG00000166747)
    Fold Change: 1.57
    Ensembl ID: ENSG00000166747
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.51
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.5
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.48
    Ensembl ID: ENSG00000152234
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.47
    Ensembl ID: ENSG00000183020
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.46
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.46
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.45
    Ensembl ID: ENSG00000162433
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.43
    Ensembl ID: ENSG00000104267
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.39
    Ensembl ID: ENSG00000107282
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.38
    Ensembl ID: ENSG00000152518
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.34
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.34
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.31
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.29
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143153
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.28
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.27
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.27
    Ensembl ID: ENSG00000145741
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.26
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.25
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.25
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.25
    Ensembl ID: ENSG00000069849
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.24
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.23
    Ensembl ID: ENSG00000033627
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.22
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.21
    Ensembl ID: ENSG00000137486
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.21
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.2
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.19
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.18
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.16
    Ensembl ID: ENSG00000035687
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.16
    Ensembl ID: ENSG00000183255
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.16
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.15
    Ensembl ID: ENSG00000148926
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.13
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.12
    Ensembl ID: ENSG00000186716
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.11
    Ensembl ID: ENSG00000151150
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.1
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.09
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.08
    Ensembl ID: ENSG00000197043
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.07
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.07
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.06
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.04
    Ensembl ID: ENSG00000131100
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.04
    Ensembl ID: ENSG00000004455
  • Gene Symbol: AMPD3 (ENSG00000133805)
    Fold Change: 1.04
    Ensembl ID: ENSG00000133805
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.03
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.01
    Ensembl ID: ENSG00000162104
Hovered Details

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Hovered Details

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**Key Characteristics** * **Hexagonal, flattened morphology**: CECs have a characteristic hexagonal shape and are flattened, allowing them to form a tight monolayer on the cornea's posterior surface. * **High mitochondrial content**: CECs have a high number of mitochondria, which enable them to regulate the tissue's energy metabolism and maintain the cornea's transparency. * **Derived from the neural crest**: CECs originate from the neural crest, a group of cells that migrate from the neural tube during embryonic development. * **Regulation of corneal transparency**: CECs play a crucial role in maintaining the cornea's transparency by regulating the tissue's water content and ion composition. * **Cell-cell adhesion**: CECs are characterized by their ability to form tight junctions with neighboring cells, which helps to maintain the cornea's transparency. **Clinical Significance** * **Corneal endothelial dysfunction**: Impaired CEC function can lead to corneal endothelial dysfunction, which can cause corneal edema, vision loss, and even blindness. * **Corneal transplantation**: CECs play a crucial role in corneal transplantation, as they are essential for maintaining the cornea's transparency and function after transplantation. * **Age-related corneal endothelial dysfunction**: As people age, CECs undergo a process called endothelial cell loss, which can lead to corneal endothelial dysfunction and vision loss. * **Corneal disease**: CECs are involved in various corneal diseases, including Fuchs' endothelial corneal dystrophy, endothelial keratoplasty, and corneal neovascularization. **Genetic Regulation** * **ZFHX3**: This gene is involved in regulating CEC function and is associated with corneal endothelial dysfunction. * **RERE**: This gene is involved in regulating CEC adhesion and migration and is associated with corneal neovascularization. * **CA12**: This gene is involved in regulating CEC function and is associated with corneal endothelial dysfunction. * **APBB2**: This gene is involved in regulating CEC adhesion and migration and is associated with corneal neovascularization. * **ALCAM**: This gene is involved in regulating CEC adhesion and migration and is associated with corneal neovascularization. * **APP**: This gene is involved in regulating CEC function and is associated with corneal endothelial dysfunction. In summary, corneal endothelial cells play a crucial role in maintaining the cornea's transparency and function, and their dysfunction can lead to various corneal diseases. Understanding the genetic regulation of CECs is essential for developing new treatments and therapies for corneal disorders.