Details for: CL0000134

Cell ID: CL0000134

Cell Name: mesenchymal stem cell

Marker Score Threshold: 1540
(Derived using integrated single-cell and genomic data)

Description: A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.

Synonyms: bone marrow stromal cells, colony-forming unit-fibroblast, marrow stromal cells, BMSC, CFU-F, MSC, mesenchymal precursor cell, mesenchymal progenitor cells, mesenchymal stem cell, mesenchymal stromal cell, mesenchymal stromal cells, stem cells, mesenchymal

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 5.48
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 5.05
    Ensembl ID: ENSG00000145741
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.99
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.72
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.33
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 4.15
    Ensembl ID: ENSG00000135390
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 4.05
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.83
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.77
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.69
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.6
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.5
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.39
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.29
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 3.19
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 3.16
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.91
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.83
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.64
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.58
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.47
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.38
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.34
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.32
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.31
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.3
    Ensembl ID: ENSG00000172270
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.28
    Ensembl ID: ENSG00000142192
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.27
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.22
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.2
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.16
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.1
    Ensembl ID: ENSG00000128272
  • Gene Symbol: C7 (ENSG00000112936)
    Fold Change: 1.91
    Ensembl ID: ENSG00000112936
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.88
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.87
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.86
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.84
    Ensembl ID: ENSG00000085224
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.84
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.84
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.82
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.78
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.69
    Ensembl ID: ENSG00000198931
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.65
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.57
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.55
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.55
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.53
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.52
    Ensembl ID: ENSG00000182492
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.5
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.45
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.43
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.41
    Ensembl ID: ENSG00000004059
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.38
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.38
    Ensembl ID: ENSG00000120805
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.37
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.36
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.35
    Ensembl ID: ENSG00000123505
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.34
    Ensembl ID: ENSG00000149131
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.3
    Ensembl ID: ENSG00000130203
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.29
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.29
    Ensembl ID: ENSG00000087274
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.28
    Ensembl ID: ENSG00000151914
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.27
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.27
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.26
    Ensembl ID: ENSG00000099624
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.25
    Ensembl ID: ENSG00000104964
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.22
    Ensembl ID: ENSG00000147872
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.22
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.22
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.2
    Ensembl ID: ENSG00000111275
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.19
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.19
    Ensembl ID: ENSG00000004455
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.18
    Ensembl ID: ENSG00000143799
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.18
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.18
    Ensembl ID: ENSG00000165029
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.17
    Ensembl ID: ENSG00000085662
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.16
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.16
    Ensembl ID: ENSG00000136717
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.15
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.15
    Ensembl ID: ENSG00000002330
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.15
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.13
    Ensembl ID: ENSG00000160710
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.13
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 1.11
    Ensembl ID: ENSG00000154188
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.1
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.08
    Ensembl ID: ENSG00000131100
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.08
    Ensembl ID: ENSG00000100300
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.08
    Ensembl ID: ENSG00000006125
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.05
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143153
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.04
    Ensembl ID: ENSG00000159403
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.03
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.02
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.01
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.01
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104763
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Immunomodulatory and anti-inflammatory properties**: MSCs have been shown to modulate the immune system and reduce inflammation, making them a potential therapeutic tool for autoimmune diseases and other inflammatory conditions. 2. **Differentiation capabilities**: MSCs can differentiate into multiple cell types, including osteoblasts, adipocytes, myocytes, neurons, and chondroblasts, making them a valuable tool in tissue engineering and regenerative medicine. 3. **Cellular plasticity**: MSCs exhibit a high degree of cellular plasticity, allowing them to adapt to different microenvironments and respond to various stimuli. 4. **Immunosuppressive effects**: MSCs have been shown to suppress the activity of immune cells, including T cells and natural killer cells, making them a potential therapeutic tool for immunosuppressive diseases. 5. **Angiogenesis and vascularization**: MSCs have been shown to promote angiogenesis and vascularization, making them a potential therapeutic tool for ischemic diseases and other conditions characterized by impaired vascularization. **Clinical Significance** 1. **Regenerative medicine**: MSCs have been explored as a potential therapeutic tool for various regenerative medicine applications, including tissue engineering, wound healing, and organ transplantation. 2. **Cancer therapy**: MSCs have been shown to have anti-tumor effects and are being explored as a potential therapeutic tool for cancer treatment. 3. **Autoimmune diseases**: MSCs have been shown to have immunomodulatory effects and are being explored as a potential therapeutic tool for autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. 4. **Neurological disorders**: MSCs have been shown to have neuroprotective effects and are being explored as a potential therapeutic tool for neurological disorders, including Parkinson's disease and Alzheimer's disease. 5. **Wound healing**: MSCs have been shown to promote wound healing and are being explored as a potential therapeutic tool for wound care. In conclusion, MSCs are a fascinating cell type with a wide range of characteristics and clinical significance. Further research is needed to fully understand the potential of MSCs as a therapeutic tool and to explore their applications in various diseases and disorders.