Details for: CL0000145

Cell ID: CL0000145

Cell Name: professional antigen presenting cell

Marker Score Threshold: 516
(Derived using integrated single-cell and genomic data)

Description: A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.

Synonyms: APC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 4.88
    Ensembl ID: ENSG00000131174
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 4.61
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 4.43
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.36
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 4.18
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.09
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.91
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 3.91
    Ensembl ID: ENSG00000241837
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 3.84
    Ensembl ID: ENSG00000127184
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.73
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.72
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.61
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 3.47
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.45
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.41
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.39
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.31
    Ensembl ID: ENSG00000154518
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 3.26
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 3.11
    Ensembl ID: ENSG00000019582
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 3.04
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 3.02
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.71
    Ensembl ID: ENSG00000176340
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.6
    Ensembl ID: ENSG00000101439
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.59
    Ensembl ID: ENSG00000198668
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.57
    Ensembl ID: ENSG00000135940
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.49
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.49
    Ensembl ID: ENSG00000169100
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.37
    Ensembl ID: ENSG00000134825
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.31
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.29
    Ensembl ID: ENSG00000116459
  • Gene Symbol: VCAN (ENSG00000038427)
    Fold Change: 2.29
    Ensembl ID: ENSG00000038427
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.22
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.15
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.15
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CTSS (ENSG00000163131)
    Fold Change: 2.09
    Ensembl ID: ENSG00000163131
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.03
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 2.02
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.98
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.9
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.85
    Ensembl ID: ENSG00000051523
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.84
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.84
    Ensembl ID: ENSG00000164733
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.78
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.77
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.73
    Ensembl ID: ENSG00000149925
  • Gene Symbol: GRK3 (ENSG00000100077)
    Fold Change: 1.67
    Ensembl ID: ENSG00000100077
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.64
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.64
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.62
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.62
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CSNK2B (ENSG00000204435)
    Fold Change: 1.58
    Ensembl ID: ENSG00000204435
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.56
    Ensembl ID: ENSG00000053254
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.55
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.49
    Ensembl ID: ENSG00000113712
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.49
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1.46
    Ensembl ID: ENSG00000047648
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.42
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143119
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.42
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.41
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.34
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.34
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.33
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.33
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.33
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 1.29
    Ensembl ID: ENSG00000135218
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.27
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.26
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CD14 (ENSG00000170458)
    Fold Change: 1.26
    Ensembl ID: ENSG00000170458
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.25
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.24
    Ensembl ID: ENSG00000090013
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.23
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.23
    Ensembl ID: ENSG00000141480
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.22
    Ensembl ID: ENSG00000142599
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.22
    Ensembl ID: ENSG00000143669
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.22
    Ensembl ID: ENSG00000221869
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.21
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.2
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.18
    Ensembl ID: ENSG00000169442
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.18
    Ensembl ID: ENSG00000172216
  • Gene Symbol: CSF3R (ENSG00000119535)
    Fold Change: 1.17
    Ensembl ID: ENSG00000119535
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.16
    Ensembl ID: ENSG00000198931
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.14
    Ensembl ID: ENSG00000102699
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.14
    Ensembl ID: ENSG00000168036
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 1.14
    Ensembl ID: ENSG00000257923
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.12
    Ensembl ID: ENSG00000084234
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.08
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.07
    Ensembl ID: ENSG00000012779
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.06
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.06
    Ensembl ID: ENSG00000109861
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.05
    Ensembl ID: ENSG00000117984
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.03
    Ensembl ID: ENSG00000141367
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.02
    Ensembl ID: ENSG00000130303
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.02
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.01
    Ensembl ID: ENSG00000127022
  • Gene Symbol: MAP3K8 (ENSG00000107968)
    Fold Change: N/A
    Ensembl ID: ENSG00000107968
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Professional Antigen-Presenting Cell**: This cell is capable of processing and presenting lipid and protein antigens to T cells, which is essential for initiating an immune response. 2. **COX7B Protein**: The cell encodes the COX7B protein, which is involved in the respiratory electron transport chain and mitochondrial biogenesis. 3. **Calcium-Mediated Signaling**: The cell regulates calcium-mediated signaling, which is involved in various cellular processes, including muscle contraction and cell communication. 4. **Cardiac Muscle Contraction**: The cell regulates cardiac muscle contraction, which is essential for maintaining cardiac function. 5. **Cell Communication**: The cell regulates cell communication by electrical coupling involved in cardiac conduction. **Clinical Significance** 1. **Immunological Disorders**: APCs play a crucial role in the adaptive immune response, and defects in APC function can lead to immunological disorders, such as autoimmune diseases and cancer. 2. **Cardiac Diseases**: The regulation of cardiac muscle contraction by this cell is essential for maintaining cardiac function, and defects in this regulation can lead to cardiac diseases, such as arrhythmias and heart failure. 3. **Neurological Disorders**: The cell's regulation of calcium-mediated signaling and cell communication by electrical coupling involved in cardiac conduction can also contribute to neurological disorders, such as epilepsy and multiple sclerosis. 4. **Cancer**: APCs can also contribute to cancer development and progression by presenting antigens to T cells that can recognize and kill tumor cells. 5. **Infectious Diseases**: The cell's role in regulating calcium-mediated signaling and cell communication can also contribute to the development and progression of infectious diseases, such as bacterial and viral infections. In conclusion, the cell in question, CL0000145, is a professional antigen-presenting cell with multiple functions, including the regulation of calcium-mediated signaling, cardiac muscle contraction, and cell communication. Its dysregulation can contribute to various clinical disorders, including immunological disorders, cardiac diseases, neurological disorders, cancer, and infectious diseases.