CL0000148 - melanocyte details

Details for: CL0000148

Cell ID: CL0000148

Cell Name: melanocyte

Marker Score Threshold: 405
(Derived using integrated single-cell and genomic data)

Description: A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance.

Synonyms: melanophore

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: B2M (ENSG00000166710)
Fold Change: 3.27
Ensembl ID: ENSG00000166710
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 2.81
Ensembl ID: ENSG00000075624
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 2.71
Ensembl ID: ENSG00000184009
Gene Symbol: BTG1 (ENSG00000133639)
Fold Change: 2.68
Ensembl ID: ENSG00000133639
Gene Symbol: ATRX (ENSG00000085224)
Fold Change: 2.31
Ensembl ID: ENSG00000085224
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 2.26
Ensembl ID: ENSG00000185650
Gene Symbol: CAST (ENSG00000153113)
Fold Change: 2.25
Ensembl ID: ENSG00000153113
Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 2.11
Ensembl ID: ENSG00000198668
Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 2.1
Ensembl ID: ENSG00000169100
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 2.03
Ensembl ID: ENSG00000145741
Gene Symbol: ANXA2 (ENSG00000182718)
Fold Change: 2.02
Ensembl ID: ENSG00000182718
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 2.02
Ensembl ID: ENSG00000067560
Gene Symbol: CAPZA1 (ENSG00000116489)
Fold Change: 2
Ensembl ID: ENSG00000116489
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.93
Ensembl ID: ENSG00000164111
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 1.9
Ensembl ID: ENSG00000135390
Gene Symbol: ASAH1 (ENSG00000104763)
Fold Change: 1.88
Ensembl ID: ENSG00000104763
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 1.86
Ensembl ID: ENSG00000124172
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 1.85
Ensembl ID: ENSG00000165629
Gene Symbol: ATP1B3 (ENSG00000069849)
Fold Change: 1.81
Ensembl ID: ENSG00000069849
Gene Symbol: APP (ENSG00000142192)
Fold Change: 1.76
Ensembl ID: ENSG00000142192
Gene Symbol: RERE (ENSG00000142599)
Fold Change: 1.74
Ensembl ID: ENSG00000142599
Gene Symbol: ATP1A1 (ENSG00000163399)
Fold Change: 1.73
Ensembl ID: ENSG00000163399
Gene Symbol: CAPZA2 (ENSG00000198898)
Fold Change: 1.73
Ensembl ID: ENSG00000198898
Gene Symbol: ADD3 (ENSG00000148700)
Fold Change: 1.69
Ensembl ID: ENSG00000148700
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.63
Ensembl ID: ENSG00000130402
Gene Symbol: CALR (ENSG00000179218)
Fold Change: 1.63
Ensembl ID: ENSG00000179218
Gene Symbol: ARF1 (ENSG00000143761)
Fold Change: 1.62
Ensembl ID: ENSG00000143761
Gene Symbol: CANX (ENSG00000127022)
Fold Change: 1.62
Ensembl ID: ENSG00000127022
Gene Symbol: AMD1 (ENSG00000123505)
Fold Change: 1.6
Ensembl ID: ENSG00000123505
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 1.59
Ensembl ID: ENSG00000169020
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.59
Ensembl ID: ENSG00000172270
Gene Symbol: ADD1 (ENSG00000087274)
Fold Change: 1.58
Ensembl ID: ENSG00000087274
Gene Symbol: CALM2 (ENSG00000143933)
Fold Change: 1.57
Ensembl ID: ENSG00000143933
Gene Symbol: PTTG1IP (ENSG00000183255)
Fold Change: 1.56
Ensembl ID: ENSG00000183255
Gene Symbol: TMEM258 (ENSG00000134825)
Fold Change: 1.55
Ensembl ID: ENSG00000134825
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 1.54
Ensembl ID: ENSG00000154518
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 1.53
Ensembl ID: ENSG00000154723
Gene Symbol: BNIP3L (ENSG00000104765)
Fold Change: 1.51
Ensembl ID: ENSG00000104765
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 1.51
Ensembl ID: ENSG00000110955
Gene Symbol: ATM (ENSG00000149311)
Fold Change: 1.48
Ensembl ID: ENSG00000149311
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 1.48
Ensembl ID: ENSG00000099624
Gene Symbol: DST (ENSG00000151914)
Fold Change: 1.47
Ensembl ID: ENSG00000151914
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 1.46
Ensembl ID: ENSG00000152234
Gene Symbol: ADAM10 (ENSG00000137845)
Fold Change: 1.45
Ensembl ID: ENSG00000137845
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 1.42
Ensembl ID: ENSG00000084234
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.4
Ensembl ID: ENSG00000160710
Gene Symbol: APOE (ENSG00000130203)
Fold Change: 1.38
Ensembl ID: ENSG00000130203
Gene Symbol: CACNB2 (ENSG00000165995)
Fold Change: 1.36
Ensembl ID: ENSG00000165995
Gene Symbol: ATF4 (ENSG00000128272)
Fold Change: 1.35
Ensembl ID: ENSG00000128272
Gene Symbol: ZFP36L2 (ENSG00000152518)
Fold Change: 1.34
Ensembl ID: ENSG00000152518
Gene Symbol: TLE5 (ENSG00000104964)
Fold Change: 1.34
Ensembl ID: ENSG00000104964
Gene Symbol: ANXA11 (ENSG00000122359)
Fold Change: 1.34
Ensembl ID: ENSG00000122359
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 1.33
Ensembl ID: ENSG00000117410
Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 1.32
Ensembl ID: ENSG00000149925
Gene Symbol: ARF4 (ENSG00000168374)
Fold Change: 1.31
Ensembl ID: ENSG00000168374
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 1.3
Ensembl ID: ENSG00000005022
Gene Symbol: ADK (ENSG00000156110)
Fold Change: 1.28
Ensembl ID: ENSG00000156110
Gene Symbol: ATP2B1 (ENSG00000070961)
Fold Change: 1.27
Ensembl ID: ENSG00000070961
Gene Symbol: CAMK2D (ENSG00000145349)
Fold Change: 1.26
Ensembl ID: ENSG00000145349
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.25
Ensembl ID: ENSG00000138279
Gene Symbol: CALM3 (ENSG00000160014)
Fold Change: 1.25
Ensembl ID: ENSG00000160014
Gene Symbol: AP2B1 (ENSG00000006125)
Fold Change: 1.21
Ensembl ID: ENSG00000006125
Gene Symbol: AK2 (ENSG00000004455)
Fold Change: 1.21
Ensembl ID: ENSG00000004455
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 1.2
Ensembl ID: ENSG00000116459
Gene Symbol: ATP6V1B2 (ENSG00000147416)
Fold Change: 1.18
Ensembl ID: ENSG00000147416
Gene Symbol: BRAF (ENSG00000157764)
Fold Change: 1.18
Ensembl ID: ENSG00000157764
Gene Symbol: CALD1 (ENSG00000122786)
Fold Change: 1.18
Ensembl ID: ENSG00000122786
Gene Symbol: APRT (ENSG00000198931)
Fold Change: 1.18
Ensembl ID: ENSG00000198931
Gene Symbol: AEBP1 (ENSG00000106624)
Fold Change: 1.16
Ensembl ID: ENSG00000106624
Gene Symbol: CALU (ENSG00000128595)
Fold Change: 1.16
Ensembl ID: ENSG00000128595
Gene Symbol: ANXA6 (ENSG00000197043)
Fold Change: 1.15
Ensembl ID: ENSG00000197043
Gene Symbol: ATP2A2 (ENSG00000174437)
Fold Change: 1.15
Ensembl ID: ENSG00000174437
Gene Symbol: ACACA (ENSG00000278540)
Fold Change: 1.15
Ensembl ID: ENSG00000278540
Gene Symbol: ATP6V1E1 (ENSG00000131100)
Fold Change: 1.14
Ensembl ID: ENSG00000131100
Gene Symbol: ARHGDIA (ENSG00000141522)
Fold Change: 1.13
Ensembl ID: ENSG00000141522
Gene Symbol: ACYP2 (ENSG00000170634)
Fold Change: 1.13
Ensembl ID: ENSG00000170634
Gene Symbol: CAPN2 (ENSG00000162909)
Fold Change: 1.12
Ensembl ID: ENSG00000162909
Gene Symbol: ACO2 (ENSG00000100412)
Fold Change: 1.11
Ensembl ID: ENSG00000100412
Gene Symbol: ANXA4 (ENSG00000196975)
Fold Change: 1.11
Ensembl ID: ENSG00000196975
Gene Symbol: ARHGAP5 (ENSG00000100852)
Fold Change: 1.09
Ensembl ID: ENSG00000100852
Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 1.08
Ensembl ID: ENSG00000241837
Gene Symbol: ABL2 (ENSG00000143322)
Fold Change: 1.08
Ensembl ID: ENSG00000143322
Gene Symbol: TSPO (ENSG00000100300)
Fold Change: 1.08
Ensembl ID: ENSG00000100300
Gene Symbol: BIRC2 (ENSG00000110330)
Fold Change: 1.07
Ensembl ID: ENSG00000110330
Gene Symbol: VPS51 (ENSG00000149823)
Fold Change: 1.06
Ensembl ID: ENSG00000149823
Gene Symbol: ADH5 (ENSG00000197894)
Fold Change: 1.06
Ensembl ID: ENSG00000197894
Gene Symbol: SERPING1 (ENSG00000149131)
Fold Change: 1.06
Ensembl ID: ENSG00000149131
Gene Symbol: XIAP (ENSG00000101966)
Fold Change: 1.05
Ensembl ID: ENSG00000101966
Gene Symbol: ASPH (ENSG00000198363)
Fold Change: 1.05
Ensembl ID: ENSG00000198363
Gene Symbol: ACADM (ENSG00000117054)
Fold Change: 1.05
Ensembl ID: ENSG00000117054
Gene Symbol: TMEM50B (ENSG00000142188)
Fold Change: 1.05
Ensembl ID: ENSG00000142188
Gene Symbol: ADSS2 (ENSG00000035687)
Fold Change: 1.05
Ensembl ID: ENSG00000035687
Gene Symbol: ATP2B4 (ENSG00000058668)
Fold Change: 1.04
Ensembl ID: ENSG00000058668
Gene Symbol: ATP5MC1 (ENSG00000159199)
Fold Change: 1.04
Ensembl ID: ENSG00000159199
Gene Symbol: APEX1 (ENSG00000100823)
Fold Change: 1.02
Ensembl ID: ENSG00000100823
Gene Symbol: ATOX1 (ENSG00000177556)
Fold Change: 1.02
Ensembl ID: ENSG00000177556
Gene Symbol: ACP1 (ENSG00000143727)
Fold Change: 1.01
Ensembl ID: ENSG00000143727
Gene Symbol: BACH1 (ENSG00000156273)
Fold Change: 1.01
Ensembl ID: ENSG00000156273
Gene Symbol: CAMLG (ENSG00000164615)
Fold Change: 1.01
Ensembl ID: ENSG00000164615
Gene Symbol: BMPR2 (ENSG00000204217)
Fold Change: N/A
Ensembl ID: ENSG00000204217

Gene representation (2152)
Gene/Pathway representation (2152)

Hovered Details

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Hovered Details

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**Key Characteristics** * Derived from the neural crest * Contain melanin-filled pigment granules * Responsible for producing and distributing melanin * Involved in the adaptive immune system, particularly in antigen processing and presentation * Play a crucial role in cellular responses to pathogens, including bacterial infections and viral infections * Express genes involved in various cellular processes, including protein binding, homodimerization, and homotetramerization * Interact with other cells and molecules, including DAP12, MHC class I, and MHC class II molecules * Involved in various signaling pathways, including interferon gamma signaling, interferon signaling, and MAPK signaling cascades **Clinical Significance** * Melanocytes play a crucial role in the adaptive immune system, particularly in antigen processing and presentation, which is essential for the development of immune responses against pathogens. * Abnormalities in melanocyte function or number can lead to various skin and hair disorders, including vitiligo, albinism, and melanoma. * Melanocytes are involved in the development of autoimmune diseases, such as autoimmune hemolytic anemia and autoimmune thyroid disease. * Melanocytes are also involved in the development of various cancers, including melanoma, basal cell carcinoma, and squamous cell carcinoma. * Understanding the role of melanocytes in the adaptive immune system and their interactions with other cells and molecules can provide insights into the development of novel therapeutic strategies for various diseases. **Pathways/Ontology** * Adaptive immune system * Amyloid fiber formation * Amyloid fibril formation * Antigen presentation: folding, assembly and peptide loading of class I MHC * Antigen processing-cross presentation * Antigen processing and presentation of endogenous peptide antigen via MHC class I * Antigen processing and presentation of exogenous peptide antigen via MHC class II * Antigen processing and presentation of exogenous protein antigen via MHC class Ib * Bacterial infection pathways * Cellular response to iron(III) ion * Cellular response to iron ion * Cellular response to nicotine * Class I MHC mediated antigen processing & presentation * Cytokine signaling in immune system * Cytosol * DAP12 interactions * DAP12 signaling * Disease * Early endosome lumen * Early endosome membrane * Endoplasmic reticulum * Endoplasmic reticulum lumen * Endosomal/vacuolar pathway * Er-phagosome pathway * Er to Golgi transport vesicle membrane * External side of plasma membrane * Extracellular exosome * Extracellular region * Extracellular space * Focal adhesion * Golgi apparatus * Golgi membrane * Hfe-transferrin receptor complex * HIV infection * Host interactions of HIV factors * Identical protein binding * Immune system * Immunoregulatory interactions between a lymphoid and a non-lymphoid cell * Infection with Mycobacterium tuberculosis * Infectious disease * Innate immune system * Interferon gamma signaling * Interferon signaling * Intracellular iron ion homeostasis * Iron ion transport * Late endosome membrane * Learning or memory * Lysosomal membrane * Membrane * Metabolism of proteins * MHC class II protein complex * MHC class II protein complex binding * MHC class I peptide loading complex * MHC class I protein complex * Modulation by Mtb of host immune system * Multicellular organismal-level iron ion homeostasis * Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters * Nef mediated downregulation of MHC class I complex cell surface expression * Negative regulation of epithelial cell proliferation * Negative regulation of forebrain neuron differentiation * Negative regulation of neurogenesis * Negative regulation of neuron projection development * Negative regulation of receptor binding * Neutrophil degranulation * Peptide antigen assembly with MHC class II protein complex * Peptide antigen assembly with MHC class I protein complex * Peptide antigen binding * Phagocytic vesicle membrane * Plasma membrane * Positive regulation of cellular senescence * Positive regulation of ferrous iron binding * Positive regulation of immune response * Positive regulation of protein binding * Positive regulation of receptor-mediated endocytosis * Positive regulation of receptor binding * Positive regulation of T cell activation * Positive regulation of T cell cytokine production * Positive regulation of T cell mediated cytotoxicity * Positive regulation of transferrin receptor binding * Protein binding * Protein homodimerization activity * Protein homotetramerization * Protein refolding * Recycling endosome membrane * Regulation of erythrocyte differentiation * Regulation of iron ion transport * Response to molecule of bacterial origin * SARS-CoV-2 activates/modulates innate and adaptive immune responses * SARS-CoV-2 infection * SARS-CoV-2-host interactions * SARS-CoV infections * Sensory perception of smell * Specific granule lumen * Structural molecule activity * T cell differentiation in thymus * T cell mediated cytotoxicity * Tertiary granule lumen * The role of Nef in HIV-1 replication and disease pathogenesis * Viral infection pathways

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.