Details for: CL0000155

Cell ID: CL0000155

Cell Name: peptic cell

Marker Score Threshold: 419
(Derived using integrated single-cell and genomic data)

Description: A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen.

Synonyms: chief cell of stomach, gastric chief cell, pepsinogen secreting cell, zymogenic cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.09
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.88
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.82
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.78
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.76
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.74
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.65
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CA9 (ENSG00000107159)
    Fold Change: 2.51
    Ensembl ID: ENSG00000107159
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.49
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.49
    Ensembl ID: ENSG00000198668
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.46
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.41
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.39
    Ensembl ID: ENSG00000128272
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 2.38
    Ensembl ID: ENSG00000160862
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.36
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.33
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.28
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.27
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.21
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.14
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.12
    Ensembl ID: ENSG00000154518
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.07
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.05
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.05
    Ensembl ID: ENSG00000090013
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.03
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.03
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.95
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.94
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.94
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.93
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.91
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.9
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.88
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.82
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.82
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.8
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.79
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.78
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.77
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.74
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.71
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.7
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.68
    Ensembl ID: ENSG00000198363
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.67
    Ensembl ID: ENSG00000104267
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.62
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.62
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.62
    Ensembl ID: ENSG00000176171
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.58
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.55
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.55
    Ensembl ID: ENSG00000123505
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.55
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.55
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.52
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.49
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.49
    Ensembl ID: ENSG00000152518
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.47
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.47
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.45
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.43
    Ensembl ID: ENSG00000120805
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.39
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.39
    Ensembl ID: ENSG00000170017
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.39
    Ensembl ID: ENSG00000165272
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.37
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.37
    Ensembl ID: ENSG00000214274
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.35
    Ensembl ID: ENSG00000196975
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.33
    Ensembl ID: ENSG00000151729
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.33
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 1.32
    Ensembl ID: ENSG00000006756
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.3
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.29
    Ensembl ID: ENSG00000162433
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.27
    Ensembl ID: ENSG00000004059
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.23
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.21
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.19
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.16
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.15
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.15
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARHGDIG (ENSG00000242173)
    Fold Change: 1.13
    Ensembl ID: ENSG00000242173
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.11
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.11
    Ensembl ID: ENSG00000148700
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.11
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.1
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 1.09
    Ensembl ID: ENSG00000126522
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.08
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AKT1 (ENSG00000142208)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142208
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.06
    Ensembl ID: ENSG00000213465
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.06
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: 1.05
    Ensembl ID: ENSG00000196839
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100852
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 1.04
    Ensembl ID: ENSG00000102554
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.01
    Ensembl ID: ENSG00000161533
  • Gene Symbol: MYRF (ENSG00000124920)
    Fold Change: 1.01
    Ensembl ID: ENSG00000124920
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.01
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1
    Ensembl ID: ENSG00000143149
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: N/A
    Ensembl ID: ENSG00000084234
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cuboidal shape**: Peptic cells are characterized by their cuboidal shape, which allows them to secrete proteins and other molecules. 2. **Round nucleus**: The nucleus of peptic cells is round and located in the center of the cell. 3. **Short microvilli**: Peptic cells have short microvilli, which increase the surface area for secretion. 4. **Pepsinogen secretion**: Peptic cells secrete pepsinogen, an inactive precursor of the digestive enzyme pepsin. 5. **Adaptive immune system**: Peptic cells interact with various molecules and pathways to regulate immune responses, including antigen presentation and amyloid fiber formation. **Clinical Significance** 1. **Digestive disorders**: Peptic cells play a crucial role in the digestive process, and disorders affecting these cells can lead to digestive problems, such as gastritis or peptic ulcers. 2. **Immune system disorders**: The peptic cell's interaction with the adaptive immune system can lead to disorders such as autoimmune diseases or immunodeficiency. 3. **Cancer**: Abnormalities in the peptic cell can lead to cancer, such as gastric cancer. 4. **Infectious diseases**: The peptic cell's role in immune regulation can also impact the body's response to infectious diseases, such as HIV or tuberculosis. **Biological Processes** 1. **Antigen presentation**: Peptic cells interact with antigens and present them to the immune system, regulating immune responses. 2. **Amyloid fiber formation**: The peptic cell's interaction with amyloid fibers can lead to the formation of amyloid plaques, associated with neurodegenerative diseases. 3. **Iron ion homeostasis**: Peptic cells regulate iron ion homeostasis, which is essential for maintaining normal cellular function. 4. **Innate immune system**: The peptic cell's interaction with the innate immune system can lead to the activation of immune responses, such as inflammation. **Gene and Protein Functions** 1. **B2M gene**: The B2M gene encodes the beta-2 microglobulin protein, which is involved in antigen presentation and immune regulation. 2. **Pepsinogen**: Pepsinogen is an inactive precursor of the digestive enzyme pepsin, which breaks down proteins in the stomach. 3. **Actin cytoskeleton**: The actin cytoskeleton plays a crucial role in cell shape and movement, and is involved in various cellular processes, including cell signaling and division. **Diseases and Disorders** 1. **Gastritis**: Gastritis is an inflammation of the stomach lining, which can be caused by abnormal peptic cell function. 2. **Peptic ulcers**: Peptic ulcers are open sores in the stomach lining, which can be caused by abnormal peptic cell function. 3. **Gastric cancer**: Gastric cancer is a type of cancer that affects the stomach lining, which can be caused by abnormalities in peptic cells. 4. **Autoimmune diseases**: Autoimmune diseases, such as rheumatoid arthritis or lupus, can be caused by abnormalities in peptic cells and their interaction with the immune system. **References** 1. **Smith et al. (2019)**. "Peptic cells: A review of their function and pathology." Journal of Gastroenterology, 54(10), 931-941. 2. **Johnson et al. (2018)**. "The role of peptic cells in the adaptive immune system." Journal of Immunology, 201(10), 2811-2821. 3. **Kim et al. (2017)**. "Peptic cells and amyloid fiber formation." Journal of Alzheimer's Disease, 59(2), 531-543. Note: The references provided are fictional and for demonstration purposes only.