CL0000158 - club cell details

Details for: CL0000158

Cell ID: CL0000158

Cell Name: club cell

Marker Score Threshold: 1167
(Derived using integrated single-cell and genomic data)

Description: A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium.

Synonyms: Clara cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: B2M (ENSG00000166710)
Fold Change: 3.98
Ensembl ID: ENSG00000166710
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 3.9
Ensembl ID: ENSG00000075624
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 3.06
Ensembl ID: ENSG00000145741
Gene Symbol: ANXA2 (ENSG00000182718)
Fold Change: 2.99
Ensembl ID: ENSG00000182718
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 2.97
Ensembl ID: ENSG00000185650
Gene Symbol: ANXA1 (ENSG00000135046)
Fold Change: 2.83
Ensembl ID: ENSG00000135046
Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 2.71
Ensembl ID: ENSG00000149925
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 2.6
Ensembl ID: ENSG00000005022
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 2.56
Ensembl ID: ENSG00000084234
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 2.5
Ensembl ID: ENSG00000067560
Gene Symbol: ATP1A1 (ENSG00000163399)
Fold Change: 2.41
Ensembl ID: ENSG00000163399
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 2.39
Ensembl ID: ENSG00000117410
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 2.34
Ensembl ID: ENSG00000172270
Gene Symbol: ATP1B1 (ENSG00000143153)
Fold Change: 2.28
Ensembl ID: ENSG00000143153
Gene Symbol: APP (ENSG00000142192)
Fold Change: 2.25
Ensembl ID: ENSG00000142192
Gene Symbol: ARF1 (ENSG00000143761)
Fold Change: 2.23
Ensembl ID: ENSG00000143761
Gene Symbol: ANXA11 (ENSG00000122359)
Fold Change: 2.22
Ensembl ID: ENSG00000122359
Gene Symbol: AQP3 (ENSG00000165272)
Fold Change: 2.21
Ensembl ID: ENSG00000165272
Gene Symbol: ASAH1 (ENSG00000104763)
Fold Change: 2.2
Ensembl ID: ENSG00000104763
Gene Symbol: ARF4 (ENSG00000168374)
Fold Change: 2.18
Ensembl ID: ENSG00000168374
Gene Symbol: ALDH1A1 (ENSG00000165092)
Fold Change: 2.17
Ensembl ID: ENSG00000165092
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 2.08
Ensembl ID: ENSG00000072778
Gene Symbol: APRT (ENSG00000198931)
Fold Change: 2.04
Ensembl ID: ENSG00000198931
Gene Symbol: ALDH2 (ENSG00000111275)
Fold Change: 1.96
Ensembl ID: ENSG00000111275
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 1.93
Ensembl ID: ENSG00000124172
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.93
Ensembl ID: ENSG00000130402
Gene Symbol: ALCAM (ENSG00000170017)
Fold Change: 1.93
Ensembl ID: ENSG00000170017
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 1.89
Ensembl ID: ENSG00000184009
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.87
Ensembl ID: ENSG00000164111
Gene Symbol: RERE (ENSG00000142599)
Fold Change: 1.79
Ensembl ID: ENSG00000142599
Gene Symbol: ATP1B3 (ENSG00000069849)
Fold Change: 1.77
Ensembl ID: ENSG00000069849
Gene Symbol: ASPH (ENSG00000198363)
Fold Change: 1.75
Ensembl ID: ENSG00000198363
Gene Symbol: RHOC (ENSG00000155366)
Fold Change: 1.73
Ensembl ID: ENSG00000155366
Gene Symbol: ANK3 (ENSG00000151150)
Fold Change: 1.73
Ensembl ID: ENSG00000151150
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.7
Ensembl ID: ENSG00000138279
Gene Symbol: ATOX1 (ENSG00000177556)
Fold Change: 1.68
Ensembl ID: ENSG00000177556
Gene Symbol: ANXA4 (ENSG00000196975)
Fold Change: 1.67
Ensembl ID: ENSG00000196975
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 1.66
Ensembl ID: ENSG00000135390
Gene Symbol: RHOB (ENSG00000143878)
Fold Change: 1.66
Ensembl ID: ENSG00000143878
Gene Symbol: KLF5 (ENSG00000102554)
Fold Change: 1.64
Ensembl ID: ENSG00000102554
Gene Symbol: BLVRB (ENSG00000090013)
Fold Change: 1.63
Ensembl ID: ENSG00000090013
Gene Symbol: BIK (ENSG00000100290)
Fold Change: 1.63
Ensembl ID: ENSG00000100290
Gene Symbol: BAG1 (ENSG00000107262)
Fold Change: 1.61
Ensembl ID: ENSG00000107262
Gene Symbol: BNIP3L (ENSG00000104765)
Fold Change: 1.6
Ensembl ID: ENSG00000104765
Gene Symbol: ATP2A2 (ENSG00000174437)
Fold Change: 1.59
Ensembl ID: ENSG00000174437
Gene Symbol: RND3 (ENSG00000115963)
Fold Change: 1.57
Ensembl ID: ENSG00000115963
Gene Symbol: CCND1 (ENSG00000110092)
Fold Change: 1.57
Ensembl ID: ENSG00000110092
Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 1.57
Ensembl ID: ENSG00000169100
Gene Symbol: ATF4 (ENSG00000128272)
Fold Change: 1.54
Ensembl ID: ENSG00000128272
Gene Symbol: ARF5 (ENSG00000004059)
Fold Change: 1.49
Ensembl ID: ENSG00000004059
Gene Symbol: AUP1 (ENSG00000115307)
Fold Change: 1.49
Ensembl ID: ENSG00000115307
Gene Symbol: AK2 (ENSG00000004455)
Fold Change: 1.48
Ensembl ID: ENSG00000004455
Gene Symbol: BAX (ENSG00000087088)
Fold Change: 1.45
Ensembl ID: ENSG00000087088
Gene Symbol: BST2 (ENSG00000130303)
Fold Change: 1.41
Ensembl ID: ENSG00000130303
Gene Symbol: ASS1 (ENSG00000130707)
Fold Change: 1.4
Ensembl ID: ENSG00000130707
Gene Symbol: ARL1 (ENSG00000120805)
Fold Change: 1.39
Ensembl ID: ENSG00000120805
Gene Symbol: APEX1 (ENSG00000100823)
Fold Change: 1.38
Ensembl ID: ENSG00000100823
Gene Symbol: BID (ENSG00000015475)
Fold Change: 1.37
Ensembl ID: ENSG00000015475
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 1.36
Ensembl ID: ENSG00000154723
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 1.34
Ensembl ID: ENSG00000154518
Gene Symbol: ACP1 (ENSG00000143727)
Fold Change: 1.34
Ensembl ID: ENSG00000143727
Gene Symbol: BIRC3 (ENSG00000023445)
Fold Change: 1.3
Ensembl ID: ENSG00000023445
Gene Symbol: AHR (ENSG00000106546)
Fold Change: 1.29
Ensembl ID: ENSG00000106546
Gene Symbol: ARHGDIB (ENSG00000111348)
Fold Change: 1.28
Ensembl ID: ENSG00000111348
Gene Symbol: ADH5 (ENSG00000197894)
Fold Change: 1.27
Ensembl ID: ENSG00000197894
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 1.25
Ensembl ID: ENSG00000169020
Gene Symbol: ARHGDIA (ENSG00000141522)
Fold Change: 1.24
Ensembl ID: ENSG00000141522
Gene Symbol: ADD3 (ENSG00000148700)
Fold Change: 1.24
Ensembl ID: ENSG00000148700
Gene Symbol: ATF3 (ENSG00000162772)
Fold Change: 1.24
Ensembl ID: ENSG00000162772
Gene Symbol: ADK (ENSG00000156110)
Fold Change: 1.22
Ensembl ID: ENSG00000156110
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 1.22
Ensembl ID: ENSG00000110955
Gene Symbol: ADAM10 (ENSG00000137845)
Fold Change: 1.2
Ensembl ID: ENSG00000137845
Gene Symbol: ACYP2 (ENSG00000170634)
Fold Change: 1.19
Ensembl ID: ENSG00000170634
Gene Symbol: BCL2L1 (ENSG00000171552)
Fold Change: 1.17
Ensembl ID: ENSG00000171552
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 1.17
Ensembl ID: ENSG00000099624
Gene Symbol: ACAT2 (ENSG00000120437)
Fold Change: 1.15
Ensembl ID: ENSG00000120437
Gene Symbol: ALDH3A1 (ENSG00000108602)
Fold Change: 1.15
Ensembl ID: ENSG00000108602
Gene Symbol: ACO2 (ENSG00000100412)
Fold Change: 1.14
Ensembl ID: ENSG00000100412
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 1.14
Ensembl ID: ENSG00000152234
Gene Symbol: ARHGAP5 (ENSG00000100852)
Fold Change: 1.14
Ensembl ID: ENSG00000100852
Gene Symbol: AAMP (ENSG00000127837)
Fold Change: 1.13
Ensembl ID: ENSG00000127837
Gene Symbol: ZFP36L2 (ENSG00000152518)
Fold Change: 1.13
Ensembl ID: ENSG00000152518
Gene Symbol: AMD1 (ENSG00000123505)
Fold Change: 1.13
Ensembl ID: ENSG00000123505
Gene Symbol: BAD (ENSG00000002330)
Fold Change: 1.11
Ensembl ID: ENSG00000002330
Gene Symbol: ATP6V1E1 (ENSG00000131100)
Fold Change: 1.1
Ensembl ID: ENSG00000131100
Gene Symbol: AQP5 (ENSG00000161798)
Fold Change: 1.1
Ensembl ID: ENSG00000161798
Gene Symbol: ADD1 (ENSG00000087274)
Fold Change: 1.09
Ensembl ID: ENSG00000087274
Gene Symbol: ARF6 (ENSG00000165527)
Fold Change: 1.08
Ensembl ID: ENSG00000165527
Gene Symbol: BMPR1B (ENSG00000138696)
Fold Change: 1.08
Ensembl ID: ENSG00000138696
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 1.07
Ensembl ID: ENSG00000165629
Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 1.06
Ensembl ID: ENSG00000241837
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 1.06
Ensembl ID: ENSG00000116459
Gene Symbol: ZFHX3 (ENSG00000140836)
Fold Change: 1.05
Ensembl ID: ENSG00000140836
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.04
Ensembl ID: ENSG00000160710
Gene Symbol: ALDH3A2 (ENSG00000072210)
Fold Change: 1.04
Ensembl ID: ENSG00000072210
Gene Symbol: ALDH1A3 (ENSG00000184254)
Fold Change: 1.04
Ensembl ID: ENSG00000184254
Gene Symbol: BMPR2 (ENSG00000204217)
Fold Change: 1.03
Ensembl ID: ENSG00000204217
Gene Symbol: ATP5MC1 (ENSG00000159199)
Fold Change: 1.01
Ensembl ID: ENSG00000159199
Gene Symbol: SLC25A4 (ENSG00000151729)
Fold Change: 1.01
Ensembl ID: ENSG00000151729
Gene Symbol: ABR (ENSG00000159842)
Fold Change: 1
Ensembl ID: ENSG00000159842

Gene representation (2168)
Gene/Pathway representation (2168)

Hovered Details

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Hovered Details

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**Key Characteristics** * Non-mucous, epithelial secretory cell * Part of the tracheobronchial tree * Short microvilli but no cilia * Capable of multiplying and differentiating into ciliated cells * Produces proteins that protect the epithelium from oxidative stress and inflammation * Associated with the adaptive immune system, amyloid fiber formation, and antigen presentation * Involved in the regulation of iron ion homeostasis, immune response, and cellular senescence **Clinical Significance** Club cells have several clinical significance in respiratory diseases. They play a crucial role in protecting the tracheobronchial epithelium from oxidative stress and inflammation, which can lead to chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and asthma. Alterations in club cell function and number have been observed in patients with COPD and asthma, suggesting that these cells may be involved in the pathogenesis of these diseases. Club cells also play a role in the regulation of iron ion homeostasis, which is essential for maintaining normal cellular function. Alterations in iron ion homeostasis can lead to anemia, which is a common complication of chronic lung diseases. In addition, club cells are involved in the regulation of the immune response, particularly in the context of respiratory infections. They produce proteins that help to regulate the immune response and prevent excessive inflammation, which can lead to tissue damage. Overall, club cells are an important component of the tracheobronchial epithelium and play a crucial role in protecting the epithelium from oxidative stress and inflammation, regulating iron ion homeostasis, and modulating the immune response. **Pathways/Ontology** Club cells are involved in several pathways and ontologies, including: * Adaptive immune system * Amyloid fiber formation * Antigen presentation: folding, assembly, and peptide loading of class I MHC * Antigen processing-cross presentation * Antigen processing and presentation of endogenous peptide antigen via MHC class I * Antigen processing and presentation of exogenous peptide antigen via MHC class II * Antigen processing and presentation of exogenous protein antigen via MHC class Ib * Bacterial infection pathways * Cellular response to iron(III) ion * Cellular response to iron ion * Cellular response to nicotine * Class I MHC-mediated antigen processing and presentation * Cytokine signaling in the immune system * Cytosol * Dap12 interactions * Dap12 signaling * Disease * Early endosome lumen * Early endosome membrane * Endoplasmic reticulum * Endoplasmic reticulum lumen * Endosomal/vacuolar pathway * Er-phagosome pathway * Er to Golgi transport vesicle membrane * External side of plasma membrane * Extracellular exosome * Extracellular region * Extracellular space * Focal adhesion * Golgi apparatus * Golgi membrane * Hfe-transferrin receptor complex * Hiv infection * Host interactions of Hiv factors * Identical protein binding * Immune system * Immunoregulatory interactions between a lymphoid and a non-lymphoid cell * Infection with Mycobacterium tuberculosis * Infectious disease * Innate immune system * Interferon gamma signaling * Interferon signaling * Intracellular iron ion homeostasis * Iron ion transport * Late endosome membrane * Learning or memory * Lysosomal membrane * Membrane * Metabolism of proteins * MHC class II protein complex * MHC class II protein complex binding * MHC class I peptide loading complex * MHC class I protein complex * Modulation by mtb of host immune system * Multicellular organismal-level iron ion homeostasis * Nef-mediates downmodulation of cell surface receptors by recruiting them to clathrin adapters * Nef-mediated downregulation of MHC class I complex cell surface expression * Negative regulation of epithelial cell proliferation * Negative regulation of forebrain neuron differentiation * Negative regulation of neurogenesis * Negative regulation of neuron projection development * Negative regulation of receptor binding * Neutrophil degranulation * Peptide antigen assembly with MHC class II protein complex * Peptide antigen assembly with MHC class I protein complex * Peptide antigen binding * Phagocytic vesicle membrane * Plasma membrane * Positive regulation of cellular senescence * Positive regulation of ferrous iron binding * Positive regulation of immune response * Positive regulation of protein binding * Positive regulation of receptor-mediated endocytosis * Positive regulation of receptor binding * Positive regulation of T cell activation * Positive regulation of T cell cytokine production * Positive regulation of T cell-mediated cytotoxicity * Positive regulation of transferrin receptor binding * Protein binding * Protein homodimerization activity * Protein homotetramerization * Protein refolding * Recycling endosome membrane * Regulation of erythrocyte differentiation * Regulation of iron ion transport * Response to molecule of bacterial origin * SARS-CoV-2 activates/modulates innate and adaptive immune responses * SARS-CoV-2 infection * SARS-CoV-2-host interactions * SARS-CoV infections * Sensory perception of smell * Specific granule lumen * Structural molecule activity * T cell differentiation in thymus * T cell-mediated cytotoxicity * Tertiary granule lumen * The role of Nef in HIV-1 replication and disease pathogenesis * Viral infection pathways

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.