Details for: CL0000160

Cell ID: CL0000160

Cell Name: goblet cell

Marker Score Threshold: 6648
(Derived using integrated single-cell and genomic data)

Description: A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules. Short microvilli project from the apical plasma membrane.

Synonyms: chalice cell

Image representation

Depiction of goblet cell
Courtesy of SwissBioPics

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ALPP (ENSG00000163283)
    Fold Change: 1.63
    Ensembl ID: ENSG00000163283
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 1.63
    Ensembl ID: ENSG00000159251
  • Gene Symbol: AVP (ENSG00000101200)
    Fold Change: 1.62
    Ensembl ID: ENSG00000101200
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: 1.16
    Ensembl ID: ENSG00000248746
  • Gene Symbol: FOXL2 (ENSG00000183770)
    Fold Change: 1.16
    Ensembl ID: ENSG00000183770
  • Gene Symbol: ADORA2A (ENSG00000128271)
    Fold Change: 1.16
    Ensembl ID: ENSG00000128271
  • Gene Symbol: ADORA3 (ENSG00000282608)
    Fold Change: 1.16
    Ensembl ID: ENSG00000282608
  • Gene Symbol: AGTR2 (ENSG00000180772)
    Fold Change: 1.16
    Ensembl ID: ENSG00000180772
  • Gene Symbol: NR0B1 (ENSG00000169297)
    Fold Change: 1.16
    Ensembl ID: ENSG00000169297
  • Gene Symbol: AMBN (ENSG00000178522)
    Fold Change: 1.16
    Ensembl ID: ENSG00000178522
  • Gene Symbol: AMELX (ENSG00000125363)
    Fold Change: 1.16
    Ensembl ID: ENSG00000125363
  • Gene Symbol: AMELY (ENSG00000099721)
    Fold Change: 1.16
    Ensembl ID: ENSG00000099721
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 1.16
    Ensembl ID: ENSG00000165462
  • Gene Symbol: ATP2B3 (ENSG00000067842)
    Fold Change: 1.16
    Ensembl ID: ENSG00000067842
  • Gene Symbol: AVPR2 (ENSG00000126895)
    Fold Change: 1.16
    Ensembl ID: ENSG00000126895
  • Gene Symbol: BRS3 (ENSG00000102239)
    Fold Change: 1.16
    Ensembl ID: ENSG00000102239
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: 1.16
    Ensembl ID: ENSG00000078549
  • Gene Symbol: AVPR1B (ENSG00000198049)
    Fold Change: 1.16
    Ensembl ID: ENSG00000198049
  • Gene Symbol: AIRE (ENSG00000160224)
    Fold Change: 1.16
    Ensembl ID: ENSG00000160224
  • Gene Symbol: APOC4 (ENSG00000267467)
    Fold Change: 1.16
    Ensembl ID: ENSG00000267467
  • Gene Symbol: NKX3 2 (ENSG00000109705)
    Fold Change: 1.16
    Ensembl ID: ENSG00000109705
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196433
  • Gene Symbol: BTN1A1 (ENSG00000124557)
    Fold Change: 1.16
    Ensembl ID: ENSG00000124557
  • Gene Symbol: AFM (ENSG00000079557)
    Fold Change: 1.16
    Ensembl ID: ENSG00000079557
  • Gene Symbol: APOF (ENSG00000175336)
    Fold Change: 1.16
    Ensembl ID: ENSG00000175336
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143632
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 1.16
    Ensembl ID: ENSG00000188778
  • Gene Symbol: ATP4A (ENSG00000105675)
    Fold Change: 1.16
    Ensembl ID: ENSG00000105675
  • Gene Symbol: ATP4B (ENSG00000186009)
    Fold Change: 1.16
    Ensembl ID: ENSG00000186009
  • Gene Symbol: APOC2 (ENSG00000234906)
    Fold Change: 1.16
    Ensembl ID: ENSG00000234906
  • Gene Symbol: ADCYAP1 (ENSG00000141433)
    Fold Change: 1.16
    Ensembl ID: ENSG00000141433
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.16
    Ensembl ID: ENSG00000158874
  • Gene Symbol: ATP1A3 (ENSG00000105409)
    Fold Change: 1.16
    Ensembl ID: ENSG00000105409
  • Gene Symbol: FASLG (ENSG00000117560)
    Fold Change: 1.16
    Ensembl ID: ENSG00000117560
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.15
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ADRA2B (ENSG00000274286)
    Fold Change: 1.15
    Ensembl ID: ENSG00000274286
  • Gene Symbol: AGTR1 (ENSG00000144891)
    Fold Change: 1.15
    Ensembl ID: ENSG00000144891
  • Gene Symbol: ATP6V1G2 (ENSG00000213760)
    Fold Change: 1.15
    Ensembl ID: ENSG00000213760
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.15
    Ensembl ID: ENSG00000163286
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.15
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ACR (ENSG00000100312)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100312
  • Gene Symbol: AHSG (ENSG00000145192)
    Fold Change: 1.15
    Ensembl ID: ENSG00000145192
  • Gene Symbol: ADGRB1 (ENSG00000181790)
    Fold Change: 1.15
    Ensembl ID: ENSG00000181790
  • Gene Symbol: ATP6V1B1 (ENSG00000116039)
    Fold Change: 1.15
    Ensembl ID: ENSG00000116039
  • Gene Symbol: ADGRB2 (ENSG00000121753)
    Fold Change: 1.15
    Ensembl ID: ENSG00000121753
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: 1.15
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ALPI (ENSG00000163295)
    Fold Change: 1.15
    Ensembl ID: ENSG00000163295
  • Gene Symbol: APLNR (ENSG00000134817)
    Fold Change: 1.15
    Ensembl ID: ENSG00000134817
  • Gene Symbol: BPI (ENSG00000101425)
    Fold Change: 1.14
    Ensembl ID: ENSG00000101425
  • Gene Symbol: OPN1SW (ENSG00000128617)
    Fold Change: 1.14
    Ensembl ID: ENSG00000128617
  • Gene Symbol: AVPR1A (ENSG00000166148)
    Fold Change: 1.14
    Ensembl ID: ENSG00000166148
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.13
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ACRV1 (ENSG00000134940)
    Fold Change: 1.13
    Ensembl ID: ENSG00000134940
  • Gene Symbol: BDNF (ENSG00000176697)
    Fold Change: 1.13
    Ensembl ID: ENSG00000176697
  • Gene Symbol: ALAS2 (ENSG00000158578)
    Fold Change: 1.13
    Ensembl ID: ENSG00000158578
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110245
  • Gene Symbol: ADRA2C (ENSG00000184160)
    Fold Change: 1.13
    Ensembl ID: ENSG00000184160
  • Gene Symbol: BGLAP (ENSG00000242252)
    Fold Change: 1.13
    Ensembl ID: ENSG00000242252
  • Gene Symbol: CRISP1 (ENSG00000124812)
    Fold Change: 1.13
    Ensembl ID: ENSG00000124812
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 1.13
    Ensembl ID: ENSG00000163485
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 1.12
    Ensembl ID: ENSG00000139352
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.12
    Ensembl ID: ENSG00000170214
  • Gene Symbol: AMY2A (ENSG00000243480)
    Fold Change: 1.12
    Ensembl ID: ENSG00000243480
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 1.12
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 1.12
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ART1 (ENSG00000129744)
    Fold Change: 1.11
    Ensembl ID: ENSG00000129744
  • Gene Symbol: ARSF (ENSG00000062096)
    Fold Change: 1.11
    Ensembl ID: ENSG00000062096
  • Gene Symbol: AQP9 (ENSG00000103569)
    Fold Change: 1.11
    Ensembl ID: ENSG00000103569
  • Gene Symbol: ATOH1 (ENSG00000172238)
    Fold Change: 1.1
    Ensembl ID: ENSG00000172238
  • Gene Symbol: AMY1A (ENSG00000237763)
    Fold Change: 1.1
    Ensembl ID: ENSG00000237763
  • Gene Symbol: BNC1 (ENSG00000169594)
    Fold Change: 1.1
    Ensembl ID: ENSG00000169594
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 1.09
    Ensembl ID: ENSG00000145692
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 1.08
    Ensembl ID: ENSG00000248144
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.07
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 1.07
    Ensembl ID: ENSG00000157087
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 1.05
    Ensembl ID: ENSG00000118520
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: 1.05
    Ensembl ID: ENSG00000175164
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.05
    Ensembl ID: ENSG00000182492
  • Gene Symbol: ACAN (ENSG00000157766)
    Fold Change: 1.05
    Ensembl ID: ENSG00000157766
  • Gene Symbol: ATP1A4 (ENSG00000132681)
    Fold Change: 1.05
    Ensembl ID: ENSG00000132681
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.05
    Ensembl ID: ENSG00000173208
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: 1.05
    Ensembl ID: ENSG00000129673
  • Gene Symbol: AMY1C (ENSG00000187733)
    Fold Change: 1.05
    Ensembl ID: ENSG00000187733
  • Gene Symbol: AQP2 (ENSG00000167580)
    Fold Change: 1.05
    Ensembl ID: ENSG00000167580
  • Gene Symbol: SERPINC1 (ENSG00000117601)
    Fold Change: 1.05
    Ensembl ID: ENSG00000117601
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.04
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.04
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.03
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.03
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.03
    Ensembl ID: ENSG00000154518
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.03
    Ensembl ID: ENSG00000130294
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.03
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.02
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.02
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.02
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1.02
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ALOX12 (ENSG00000108839)
    Fold Change: 1.02
    Ensembl ID: ENSG00000108839
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.01
    Ensembl ID: ENSG00000159199
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.01
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1
    Ensembl ID: ENSG00000241837
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Morphology**: Goblet cells are columnar epithelial cells with a narrow basal end containing the nucleus and a swollen apical end filled with mucus-laden secretory granules. 2. **Function**: Goblet cells secrete mucins, which form the mucus that lubricates and protects the respiratory, gastrointestinal, and genitourinary tracts. 3. **Gene Symbol**: ALPP (Alkaline Phosphatase) 4. **Pathways/Ontology**: Intra-golgi and retrograde golgi-to-er traffic, Intra-golgi traffic, Alkaline phosphatase activity, Cell surface, Dephosphorylation, Magnesium ion binding, Zinc ion binding **Clinical Significance** Goblet cells play a crucial role in maintaining the integrity of the epithelial barrier, and their dysfunction can lead to various diseases and disorders, including: 1. **Respiratory diseases**: Goblet cell dysfunction can contribute to respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Gastrointestinal diseases**: Goblet cell dysfunction can contribute to gastrointestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). 3. **Genitourinary diseases**: Goblet cell dysfunction can contribute to genitourinary diseases such as urinary tract infections (UTIs) and bladder cancer. 4. **Cancer**: Goblet cell dysfunction has been implicated in the development of certain types of cancer, including colorectal cancer and bladder cancer. In conclusion, goblet cells are specialized epithelial cells that play a crucial role in maintaining the integrity of the epithelial barrier, and their dysfunction can lead to various diseases and disorders. Further research is needed to fully understand the mechanisms of goblet cell function and dysfunction, and to develop effective treatments for goblet cell-related diseases.