Details for: CL0000163

Cell ID: CL0000163

Cell Name: endocrine cell

Marker Score Threshold: 517
(Derived using integrated single-cell and genomic data)

Description: A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.

Synonyms: endocrinocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 4.88
    Ensembl ID: ENSG00000141837
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.96
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 3.94
    Ensembl ID: ENSG00000165995
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 3.81
    Ensembl ID: ENSG00000151067
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 3.63
    Ensembl ID: ENSG00000153956
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.45
    Ensembl ID: ENSG00000142599
  • Gene Symbol: FXYD2 (ENSG00000137731)
    Fold Change: 3.38
    Ensembl ID: ENSG00000137731
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 3.37
    Ensembl ID: ENSG00000179218
  • Gene Symbol: AZGP1 (ENSG00000160862)
    Fold Change: 3.21
    Ensembl ID: ENSG00000160862
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.07
    Ensembl ID: ENSG00000142192
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.03
    Ensembl ID: ENSG00000151914
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 3
    Ensembl ID: ENSG00000105290
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.9
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.87
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP2A3 (ENSG00000074370)
    Fold Change: 2.85
    Ensembl ID: ENSG00000074370
  • Gene Symbol: CASR (ENSG00000036828)
    Fold Change: 2.82
    Ensembl ID: ENSG00000036828
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.8
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 2.69
    Ensembl ID: ENSG00000079102
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.59
    Ensembl ID: ENSG00000143933
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.56
    Ensembl ID: ENSG00000169100
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.53
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.52
    Ensembl ID: ENSG00000154723
  • Gene Symbol: KLK3 (ENSG00000142515)
    Fold Change: 2.51
    Ensembl ID: ENSG00000142515
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.49
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.39
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.38
    Ensembl ID: ENSG00000169020
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 2.33
    Ensembl ID: ENSG00000130294
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.3
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 2.25
    Ensembl ID: ENSG00000157388
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.22
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 2.22
    Ensembl ID: ENSG00000108684
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.18
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.17
    Ensembl ID: ENSG00000184009
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.14
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.01
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.97
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.97
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.94
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.91
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.91
    Ensembl ID: ENSG00000077549
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.87
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.86
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.81
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.77
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.77
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CAMK2B (ENSG00000058404)
    Fold Change: 1.77
    Ensembl ID: ENSG00000058404
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.76
    Ensembl ID: ENSG00000157764
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.74
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.73
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.71
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACP3 (ENSG00000014257)
    Fold Change: 1.68
    Ensembl ID: ENSG00000014257
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.67
    Ensembl ID: ENSG00000151746
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.65
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: 1.64
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.6
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.6
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.54
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.53
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165629
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.49
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.49
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.47
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.46
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.46
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.4
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.39
    Ensembl ID: ENSG00000058668
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.37
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 1.37
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.36
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ASCL2 (ENSG00000183734)
    Fold Change: 1.35
    Ensembl ID: ENSG00000183734
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.34
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.34
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.33
    Ensembl ID: ENSG00000033627
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.32
    Ensembl ID: ENSG00000114573
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.31
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.3
    Ensembl ID: ENSG00000159199
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.29
    Ensembl ID: ENSG00000183255
  • Gene Symbol: AKT1 (ENSG00000142208)
    Fold Change: 1.28
    Ensembl ID: ENSG00000142208
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.27
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.26
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.24
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.23
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.22
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.22
    Ensembl ID: ENSG00000134982
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.19
    Ensembl ID: ENSG00000005022
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.13
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 1.12
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.11
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.08
    Ensembl ID: ENSG00000184254
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.08
    Ensembl ID: ENSG00000185650
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.06
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: 1.05
    Ensembl ID: ENSG00000107331
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.04
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.03
    Ensembl ID: ENSG00000097007
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.03
    Ensembl ID: ENSG00000168374
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.01
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1
    Ensembl ID: ENSG00000104765
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Endocrine Cell**: The cell is an endocrine cell, a type of ductless gland cell that secretes substances directly into the circulation. 2. **High-Voltage-Gated Calcium Channel Activity**: The cell is associated with high-voltage-gated calcium channel activity, which is a key mechanism for regulating calcium ion concentration. 3. **Calcium Ion Import Across Plasma Membrane**: The cell is involved in the import of calcium ions across the plasma membrane, which is essential for various cellular processes. 4. **Calcium Ion Transmembrane Transport**: The cell is also involved in the transmembrane transport of calcium ions, which is critical for regulating cellular signaling pathways. 5. **Association with Neuronal Transmission**: The cell is linked to neuronal transmission, including presynaptic depolarization and calcium channel opening. 6. **Regulation of Insulin Secretion**: The cell is involved in regulating insulin secretion, a critical function in glucose metabolism. 7. **Association with Immune Response**: The cell is also associated with immune response, including the activation of adaptive immune cells and the regulation of cytokine production. **Clinical Significance** 1. **Regulation of Metabolism**: The cell plays a critical role in regulating metabolism, including glucose and lipid metabolism. 2. **Insulin Secretion**: The cell is involved in regulating insulin secretion, which is essential for maintaining normal blood glucose levels. 3. **Neurological Disorders**: The cell's association with neuronal transmission and calcium ion regulation makes it relevant to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immune System**: The cell's involvement in immune response makes it relevant to immune system disorders, such as autoimmune diseases. 5. **Cancer**: The cell's association with signaling pathways involved in cell growth and division makes it relevant to cancer research. In conclusion, the cell described in this entry is an endocrine cell that plays a critical role in regulating metabolism, insulin secretion, and immune response. Its association with neuronal transmission, calcium ion regulation, and signaling pathways makes it relevant to various neurological and immune system disorders. Further research is needed to fully understand the function and clinical significance of this cell.