Details for: CL0000165

Cell ID: CL0000165

Cell Name: neuroendocrine cell

Marker Score Threshold: 389
(Derived using integrated single-cell and genomic data)

Description: A neuron that is capable of some hormone secretion in response to neuronal signals.

Synonyms: neurosecretory cell, neurosecretory neuron

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: 4.64
    Ensembl ID: ENSG00000248746
  • Gene Symbol: BDKRB2 (ENSG00000168398)
    Fold Change: 3.58
    Ensembl ID: ENSG00000168398
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.09
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.95
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.94
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.77
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ASGR2 (ENSG00000161944)
    Fold Change: 2.55
    Ensembl ID: ENSG00000161944
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.53
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.51
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.5
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.5
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.44
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.43
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.34
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.22
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.17
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.14
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.09
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.07
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.98
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ADAM8 (ENSG00000151651)
    Fold Change: 1.96
    Ensembl ID: ENSG00000151651
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.95
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.91
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.9
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.89
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.89
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP4A (ENSG00000105675)
    Fold Change: 1.88
    Ensembl ID: ENSG00000105675
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.88
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.86
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.83
    Ensembl ID: ENSG00000143761
  • Gene Symbol: AQP7 (ENSG00000165269)
    Fold Change: 1.82
    Ensembl ID: ENSG00000165269
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.81
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.76
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.74
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.73
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.71
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.66
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.65
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.62
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.6
    Ensembl ID: ENSG00000127022
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.59
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.58
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.57
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.57
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.54
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.52
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.51
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.43
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.43
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.42
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.39
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.39
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.37
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.34
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.33
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.33
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.33
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.32
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.29
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.27
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.27
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.25
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.24
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.24
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.2
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.2
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.19
    Ensembl ID: ENSG00000026508
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.19
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.18
    Ensembl ID: ENSG00000153922
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.18
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.17
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP6V1B1 (ENSG00000116039)
    Fold Change: 1.17
    Ensembl ID: ENSG00000116039
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.17
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104763
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.16
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.14
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.12
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.11
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.11
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.11
    Ensembl ID: ENSG00000112576
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.1
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.07
    Ensembl ID: ENSG00000109861
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.06
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.06
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.05
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.03
    Ensembl ID: ENSG00000087274
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.01
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.01
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: N/A
    Ensembl ID: ENSG00000111642
Hovered Details

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Hovered Details

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**Key Characteristics** The neuroendocrine cell is a unique type of neuron that possesses the ability to secrete hormones in response to neuronal signals. It is characterized by its: 1. **Hormone secretion**: The neuroendocrine cell is capable of secreting hormones, which are signaling molecules that regulate various physiological processes. 2. **Muscle contraction regulation**: The neuroendocrine cell regulates muscle contraction, including skeletal muscle fiber contraction and relaxation. 3. **Cell differentiation regulation**: The neuroendocrine cell regulates cell differentiation, including the development of muscle cells and other cell types. 4. **Apoptosis regulation**: The neuroendocrine cell regulates apoptosis, or programmed cell death, which is involved in various physiological and pathological processes. **Clinical Significance** The neuroendocrine cell plays a crucial role in various clinical conditions, including: 1. **Muscle atrophy**: The neuroendocrine cell is involved in the regulation of muscle atrophy, which is a condition characterized by the loss of muscle mass and strength. 2. **Skeletal muscle development**: The neuroendocrine cell regulates skeletal muscle development, which is essential for muscle growth and repair. 3. **Cancer**: The neuroendocrine cell is involved in the regulation of cancer, including the development and progression of tumors. 4. **Neurological disorders**: The neuroendocrine cell is involved in the regulation of various neurological disorders, including Parkinson's disease and Alzheimer's disease. **Signaling Pathways** The neuroendocrine cell is involved in various signaling pathways, including: 1. **Actin cytoskeleton organization**: The neuroendocrine cell regulates the organization of the actin cytoskeleton, which is essential for muscle contraction and cell motility. 2. **G protein-coupled receptor signaling pathway**: The neuroendocrine cell is involved in the regulation of G protein-coupled receptor signaling pathways, which are essential for hormone secretion and other cellular processes. 3. **Rho GTPase cycle**: The neuroendocrine cell regulates the Rho GTPase cycle, which is involved in the regulation of muscle contraction and cell motility. 4. **Calcium ion binding**: The neuroendocrine cell regulates calcium ion binding, which is essential for muscle contraction and other cellular processes. In conclusion, the neuroendocrine cell is a unique type of neuron that plays a crucial role in various physiological and pathological processes, including muscle contraction, cell differentiation, and apoptosis. Its signaling pathways, including actin cytoskeleton organization, G protein-coupled receptor signaling pathway, Rho GTPase cycle, and calcium ion binding, are essential for its function and regulation. Further research is needed to fully understand the role of the neuroendocrine cell in various clinical conditions.