Details for: CL0000169

Cell ID: CL0000169

Cell Name: type B pancreatic cell

Marker Score Threshold: 992
(Derived using integrated single-cell and genomic data)

Description: A cell that secretes insulin and is located towards the center of the islets of Langerhans.

Synonyms: beta cell, B-cell of pancreatic islet, beta cell of pancreatic islet, insulin-secreting cell, pancreatic B cell, pancreatic B-cell, pancreatic beta cell, pancreatic islet core, type B enteroendocrine cell, beta cell islet

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 4.96
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 3.88
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.19
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.04
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.67
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.66
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.66
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.46
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.45
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.36
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.33
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.32
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 2.19
    Ensembl ID: ENSG00000110245
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.07
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.07
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.02
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.02
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.99
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.96
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.95
    Ensembl ID: ENSG00000154518
  • Gene Symbol: APOA4 (ENSG00000110244)
    Fold Change: 1.94
    Ensembl ID: ENSG00000110244
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.93
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.91
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.9
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD8B (ENSG00000172116)
    Fold Change: 1.89
    Ensembl ID: ENSG00000172116
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.87
    Ensembl ID: ENSG00000172270
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.84
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.79
    Ensembl ID: ENSG00000026508
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 1.75
    Ensembl ID: ENSG00000198821
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.74
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.71
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.64
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.63
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.63
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.63
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.59
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.57
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.56
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.55
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.55
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.53
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.52
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.5
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.49
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.49
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.49
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: 1.47
    Ensembl ID: ENSG00000110881
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.47
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.46
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.45
    Ensembl ID: ENSG00000162772
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.43
    Ensembl ID: ENSG00000119138
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.42
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.42
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.41
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.4
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.4
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.39
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.38
    Ensembl ID: ENSG00000111348
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.33
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.3
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.3
    Ensembl ID: ENSG00000069849
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.29
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: 1.28
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.26
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104765
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.26
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.24
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.24
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.22
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.21
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.2
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.19
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.18
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.17
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.16
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.16
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADORA2B (ENSG00000170425)
    Fold Change: 1.15
    Ensembl ID: ENSG00000170425
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.14
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.13
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.11
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.1
    Ensembl ID: ENSG00000156273
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.09
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.09
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.08
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CA4 (ENSG00000167434)
    Fold Change: 1.08
    Ensembl ID: ENSG00000167434
  • Gene Symbol: CCNT1 (ENSG00000129315)
    Fold Change: 1.08
    Ensembl ID: ENSG00000129315
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.05
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.05
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CAMK2G (ENSG00000148660)
    Fold Change: 1.05
    Ensembl ID: ENSG00000148660
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BMI1 (ENSG00000168283)
    Fold Change: 1.03
    Ensembl ID: ENSG00000168283
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.03
    Ensembl ID: ENSG00000186716
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.03
    Ensembl ID: ENSG00000162909
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.01
    Ensembl ID: ENSG00000155366
Hovered Details

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Hovered Details

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**Key Characteristics** The type B pancreatic cell has several key characteristics that enable it to function properly: 1. **Insulin secretion**: The cell is responsible for producing and secreting insulin in response to changes in blood glucose levels. 2. **Location**: The cell is located in the islets of Langerhans, a cluster of cells in the pancreas that play a crucial role in regulating blood sugar levels. 3. **Genetic identity**: The cell's genetic identity is characterized by the presence of specific genes, including SLC25A6, BCL2, and ACTB, which are involved in various cellular processes such as metabolism, apoptosis, and protein localization. 4. **Apoptosis regulation**: The cell's genetic profile includes genes involved in apoptosis regulation, such as BCL2, which plays a crucial role in regulating cell death. 5. **Cellular localization**: The cell's genetic profile also includes genes involved in cellular localization, such as ACTB, which is involved in protein localization and trafficking. **Clinical Significance** The type B pancreatic cell plays a crucial role in regulating blood sugar levels, and dysfunction of these cells has been implicated in various diseases, including: 1. **Diabetes**: Type 1 diabetes is characterized by the autoimmune destruction of beta cells, leading to insulin deficiency and hyperglycemia. Type 2 diabetes is characterized by insulin resistance and impaired insulin secretion. 2. **Pancreatic beta cell dysfunction**: Pancreatic beta cell dysfunction is characterized by impaired insulin secretion and glucose intolerance. 3. **Insulin resistance**: Insulin resistance is a condition in which the body's cells become less responsive to insulin, leading to hyperglycemia. 4. **Glycemic control**: The type B pancreatic cell plays a crucial role in regulating glycemic control, and dysfunction of these cells can lead to hyperglycemia and metabolic disorders. In conclusion, the type B pancreatic cell is a critical component of the pancreatic islets of Langerhans, responsible for producing and secreting insulin in response to changes in blood glucose levels. Dysfunction of these cells has been implicated in various diseases, including diabetes, pancreatic beta cell dysfunction, insulin resistance, and glycemic control.