Details for: CL0000171

Cell ID: CL0000171

Cell Name: pancreatic A cell

Marker Score Threshold: 979
(Derived using integrated single-cell and genomic data)

Description: A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon.

Synonyms: alpha cell of islet of Langerhans, pancreatic alpha cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 6.42
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 5.78
    Ensembl ID: ENSG00000177556
  • Gene Symbol: DDT (ENSG00000099977)
    Fold Change: 4.85
    Ensembl ID: ENSG00000099977
  • Gene Symbol: CTSL (ENSG00000135047)
    Fold Change: 4.6
    Ensembl ID: ENSG00000135047
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 4.25
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CLDN3 (ENSG00000165215)
    Fold Change: 3.63
    Ensembl ID: ENSG00000165215
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.9
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ASNS (ENSG00000070669)
    Fold Change: 2.6
    Ensembl ID: ENSG00000070669
  • Gene Symbol: ECI1 (ENSG00000167969)
    Fold Change: 2.58
    Ensembl ID: ENSG00000167969
  • Gene Symbol: CYB5R3 (ENSG00000100243)
    Fold Change: 2.31
    Ensembl ID: ENSG00000100243
  • Gene Symbol: CD55 (ENSG00000196352)
    Fold Change: 1.99
    Ensembl ID: ENSG00000196352
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143878
  • Gene Symbol: DNM1 (ENSG00000106976)
    Fold Change: 1.86
    Ensembl ID: ENSG00000106976
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.86
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.85
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.84
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.8
    Ensembl ID: ENSG00000131143
  • Gene Symbol: DCK (ENSG00000156136)
    Fold Change: 1.77
    Ensembl ID: ENSG00000156136
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.75
    Ensembl ID: ENSG00000184009
  • Gene Symbol: DDB1 (ENSG00000167986)
    Fold Change: 1.71
    Ensembl ID: ENSG00000167986
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.71
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.68
    Ensembl ID: ENSG00000127184
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.68
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.67
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CENPB (ENSG00000125817)
    Fold Change: 1.66
    Ensembl ID: ENSG00000125817
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.65
    Ensembl ID: ENSG00000143933
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.65
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.64
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.63
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.62
    Ensembl ID: ENSG00000176340
  • Gene Symbol: DDIT3 (ENSG00000175197)
    Fold Change: 1.61
    Ensembl ID: ENSG00000175197
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.59
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CLPTM1 (ENSG00000104853)
    Fold Change: 1.59
    Ensembl ID: ENSG00000104853
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.57
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.56
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CDK11B (ENSG00000248333)
    Fold Change: 1.55
    Ensembl ID: ENSG00000248333
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.54
    Ensembl ID: ENSG00000155368
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.53
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.53
    Ensembl ID: ENSG00000120437
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.52
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CRABP2 (ENSG00000143320)
    Fold Change: 1.52
    Ensembl ID: ENSG00000143320
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.51
    Ensembl ID: ENSG00000122545
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.51
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.51
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.48
    Ensembl ID: ENSG00000101439
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.48
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.47
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.47
    Ensembl ID: ENSG00000172270
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.47
    Ensembl ID: ENSG00000135940
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.45
    Ensembl ID: ENSG00000129562
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.44
    Ensembl ID: ENSG00000005022
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.44
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.44
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.43
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CTSZ (ENSG00000101160)
    Fold Change: 1.42
    Ensembl ID: ENSG00000101160
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.4
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.39
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.39
    Ensembl ID: ENSG00000160213
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.39
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.37
    Ensembl ID: ENSG00000116459
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.36
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.33
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.32
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.32
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.32
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.31
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CRK (ENSG00000167193)
    Fold Change: 1.31
    Ensembl ID: ENSG00000167193
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 1.3
    Ensembl ID: ENSG00000120885
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.23
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.22
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CBR1 (ENSG00000159228)
    Fold Change: 1.21
    Ensembl ID: ENSG00000159228
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.21
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.2
    Ensembl ID: ENSG00000128272
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.19
    Ensembl ID: ENSG00000215301
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.19
    Ensembl ID: ENSG00000175416
  • Gene Symbol: DMWD (ENSG00000185800)
    Fold Change: 1.18
    Ensembl ID: ENSG00000185800
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.16
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.16
    Ensembl ID: ENSG00000117984
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.13
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.12
    Ensembl ID: ENSG00000185650
  • Gene Symbol: SEPTIN1 (ENSG00000180096)
    Fold Change: 1.11
    Ensembl ID: ENSG00000180096
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.09
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.09
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.08
    Ensembl ID: ENSG00000122705
  • Gene Symbol: DHX9 (ENSG00000135829)
    Fold Change: 1.08
    Ensembl ID: ENSG00000135829
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.08
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.07
    Ensembl ID: ENSG00000124762
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.05
    Ensembl ID: ENSG00000051523
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.05
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.04
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CDA (ENSG00000158825)
    Fold Change: 1.03
    Ensembl ID: ENSG00000158825
  • Gene Symbol: CKS1B (ENSG00000173207)
    Fold Change: 1.02
    Ensembl ID: ENSG00000173207
  • Gene Symbol: CPE (ENSG00000109472)
    Fold Change: 1.01
    Ensembl ID: ENSG00000109472
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.01
    Ensembl ID: ENSG00000119640
Hovered Details

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Hovered Details

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**Key Characteristics** The pancreatic A cell is characterized by its ability to secrete glucagon, which is essential for maintaining blood glucose homeostasis. The cell's gene symbol, SLC25A6, is involved in various cellular processes, including: * Apoptotic process: The cell is involved in programmed cell death, which is essential for maintaining tissue homeostasis. * ATP:ADP antiporter activity: The cell is involved in the transport of ATP and ADP across the mitochondrial inner membrane. * Disease: The cell is involved in various diseases, including diabetes and cancer. * HIV infection: The cell interacts with HIV factors and is a target for HIV infection. * Immune system: The cell plays a role in the immune system, including the activation of immune cells and the production of cytokines. * Metabolism of proteins: The cell is involved in the metabolism of proteins, including the breakdown and synthesis of proteins. **Clinical Significance** The pancreatic A cell is clinically significant due to its role in maintaining blood glucose homeostasis. Abnormalities in the cell's function can lead to various diseases, including: * Diabetes: The cell's inability to secrete glucagon can lead to hypoglycemia, while its overactivity can lead to hyperglycemia. * Cancer: The cell's ability to evade apoptosis can lead to cancer development and progression. * Influenza: The cell's interaction with influenza viruses can lead to severe respiratory disease. Understanding the function and characteristics of the pancreatic A cell is essential for the development of novel therapies for various diseases. Additionally, the cell's interaction with HIV factors and its role in the immune system make it an important target for the development of HIV therapies. **Other Key Features** The cell also interacts with other cells and proteins, including: * Other pancreatic cells: The cell interacts with other pancreatic cells, including beta cells and delta cells, to maintain blood glucose homeostasis. * Immune cells: The cell interacts with immune cells, including T cells and macrophages, to activate the immune response. * Viruses: The cell interacts with viruses, including influenza and HIV, to evade the immune response and establish infection. Overall, the pancreatic A cell is a complex cell type that plays a critical role in maintaining blood glucose homeostasis and interacting with the immune system. Understanding its function and characteristics is essential for the development of novel therapies for various diseases.