Details for: CL0000173

Cell ID: CL0000173

Cell Name: pancreatic D cell

Marker Score Threshold: 435
(Derived using integrated single-cell and genomic data)

Description: A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin.

Synonyms: D-cell of pancreatic islet, delta cell of islet, delta cell of pancreatic islet, pancreatic D-cell, pancreatic delta cell, somatostatin-secreting pancreatic cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.54
    Ensembl ID: ENSG00000166710
  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: 2.48
    Ensembl ID: ENSG00000121410
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.41
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.36
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.35
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.35
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.31
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.29
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.26
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.24
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.22
    Ensembl ID: ENSG00000135404
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.22
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.21
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.07
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.06
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.98
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CBR1 (ENSG00000159228)
    Fold Change: 1.95
    Ensembl ID: ENSG00000159228
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.95
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.93
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.9
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.86
    Ensembl ID: ENSG00000005022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.82
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.81
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.8
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.8
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.78
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.77
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.75
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.72
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.71
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.7
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.7
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.7
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.69
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.69
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.64
    Ensembl ID: ENSG00000004059
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.57
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.57
    Ensembl ID: ENSG00000128272
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.56
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.55
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.53
    Ensembl ID: ENSG00000124762
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.53
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.52
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.47
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.46
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.45
    Ensembl ID: ENSG00000077549
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.44
    Ensembl ID: ENSG00000198898
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.42
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.41
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.41
    Ensembl ID: ENSG00000143153
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.39
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.35
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.33
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.32
    Ensembl ID: ENSG00000138175
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.3
    Ensembl ID: ENSG00000213465
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.29
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.26
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.24
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.23
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.22
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.18
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.18
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.17
    Ensembl ID: ENSG00000196954
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.16
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.16
    Ensembl ID: ENSG00000182718
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.15
    Ensembl ID: ENSG00000108561
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138760
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.15
    Ensembl ID: ENSG00000162909
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.15
    Ensembl ID: ENSG00000164615
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.14
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.12
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.12
    Ensembl ID: ENSG00000085063
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.11
    Ensembl ID: ENSG00000176171
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.1
    Ensembl ID: ENSG00000105254
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.09
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.08
    Ensembl ID: ENSG00000146731
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.08
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.08
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.08
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CHGA (ENSG00000100604)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100604
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.06
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AP1S1 (ENSG00000106367)
    Fold Change: 1.06
    Ensembl ID: ENSG00000106367
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.06
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.04
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.04
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.03
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.03
    Ensembl ID: ENSG00000197043
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 1.03
    Ensembl ID: ENSG00000166165
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.02
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.02
    Ensembl ID: ENSG00000019582
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.01
    Ensembl ID: ENSG00000115307
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.01
    Ensembl ID: ENSG00000151729
Hovered Details

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Hovered Details

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**Key Characteristics** The pancreatic D cell is a type of endocrine cell that is characterized by the following features: 1. **Location**: The D cell is located in the islets of Langerhans within the pancreas. 2. **Somatostatin secretion**: The D cell secretes somatostatin, a hormone that inhibits the release of other hormones. 3. **Inhibitory effects**: Somatostatin inhibits the release of insulin and glucagon, thereby regulating glucose homeostasis. 4. **Immune regulatory effects**: Somatostatin has been shown to have immunomodulatory effects, including inhibiting the activation of T cells and promoting the production of anti-inflammatory cytokines. **Clinical Significance** The pancreatic D cell plays a crucial role in regulating various physiological processes, including: 1. **Glucose homeostasis**: The D cell helps regulate glucose homeostasis by inhibiting the release of insulin and glucagon. 2. **Digestion**: Somatostatin inhibits the release of digestive enzymes, thereby regulating digestion. 3. **Immune responses**: Somatostatin has immunomodulatory effects, including inhibiting the activation of T cells and promoting the production of anti-inflammatory cytokines. Dysregulation of the pancreatic D cell has been implicated in various diseases, including: 1. **Type 2 diabetes**: Dysregulation of the D cell has been linked to the development of type 2 diabetes. 2. **Pancreatic cancer**: The D cell has been shown to be involved in the development of pancreatic cancer. **Pathways** The pancreatic D cell is involved in various signaling pathways, including: 1. **Adaptive immune system**: The D cell is involved in the adaptive immune system, including the activation of T cells and the production of anti-inflammatory cytokines. 2. **Amyloid fiber formation**: Somatostatin has been shown to inhibit the formation of amyloid fibers, which are associated with neurodegenerative diseases. 3. **Antigen presentation**: The D cell is involved in the presentation of antigens to T cells, including the presentation of exogenous peptide antigens via MHC class II. 4. **Cytokine signaling**: Somatostatin has been shown to modulate cytokine signaling, including the production of anti-inflammatory cytokines. In conclusion, the pancreatic D cell is a critical component of the endocrine system, playing a key role in regulating glucose homeostasis, digestion, and immune responses. Dysregulation of the D cell has been implicated in various diseases, including type 2 diabetes and pancreatic cancer. Further research is needed to fully understand the role of the D cell in human physiology and disease.