Details for: CL0000178

Cell ID: CL0000178

Cell Name: Leydig cell

Marker Score Threshold: 1078
(Derived using integrated single-cell and genomic data)

Description: A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.

Synonyms: interstitial cell, interstitial cell of Leydig

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.43
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.42
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.38
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.37
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.36
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.3
    Ensembl ID: ENSG00000169100
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.3
    Ensembl ID: ENSG00000166710
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.3
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.29
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.29
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.26
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.26
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.25
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.19
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.18
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.17
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 2.12
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.1
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.09
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.08
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.05
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.05
    Ensembl ID: ENSG00000118137
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.03
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.01
    Ensembl ID: ENSG00000116459
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2
    Ensembl ID: ENSG00000104964
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.99
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.98
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.95
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.94
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.93
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.92
    Ensembl ID: ENSG00000197894
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.88
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.83
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.82
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.82
    Ensembl ID: ENSG00000196961
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.81
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.81
    Ensembl ID: ENSG00000130707
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.81
    Ensembl ID: ENSG00000143878
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.79
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.75
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 1.69
    Ensembl ID: ENSG00000135409
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.69
    Ensembl ID: ENSG00000115307
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.67
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.67
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.66
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.65
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.65
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.65
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.65
    Ensembl ID: ENSG00000143149
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.61
    Ensembl ID: ENSG00000004455
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 1.58
    Ensembl ID: ENSG00000101384
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.57
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.56
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.5
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.5
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.48
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.48
    Ensembl ID: ENSG00000131473
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.45
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.45
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.44
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ALAS1 (ENSG00000023330)
    Fold Change: 1.43
    Ensembl ID: ENSG00000023330
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.42
    Ensembl ID: ENSG00000071553
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.4
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.36
    Ensembl ID: ENSG00000160710
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.34
    Ensembl ID: ENSG00000198356
  • Gene Symbol: AKT2 (ENSG00000105221)
    Fold Change: 1.3
    Ensembl ID: ENSG00000105221
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.3
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.27
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.27
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.27
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ALDH1B1 (ENSG00000137124)
    Fold Change: 1.26
    Ensembl ID: ENSG00000137124
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.25
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.21
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.19
    Ensembl ID: ENSG00000278540
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.18
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.17
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.17
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.16
    Ensembl ID: ENSG00000239900
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.16
    Ensembl ID: ENSG00000136717
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.15
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.14
    Ensembl ID: ENSG00000198363
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 1.13
    Ensembl ID: ENSG00000162688
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.12
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.11
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.1
    Ensembl ID: ENSG00000095139
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.1
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.1
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.1
    Ensembl ID: ENSG00000204574
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.09
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.09
    Ensembl ID: ENSG00000100412
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.08
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.07
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.07
    Ensembl ID: ENSG00000104763
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.07
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.06
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.03
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.01
    Ensembl ID: ENSG00000111275
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Location**: Leydig cells are located in the interstitial area between the seminiferous tubules in the testis. 2. **Function**: Leydig cells produce testosterone, a hormone essential for male reproductive and development processes. 3. **Gene Expression**: Leydig cells have a unique gene expression profile, involving a wide range of biological pathways, including acylglycerol homeostasis, amyloid-beta binding, and cholesterol metabolism. 4. **Signaling Pathways**: The cell's function is tightly regulated by various signaling pathways, including cGMP-mediated signaling, which is essential for testosterone production. 5. **Cellular Organization**: Leydig cells are characterized by their cytoskeletal organization, which plays a crucial role in cell signaling and hormone production. **Clinical Significance** 1. **Hypogonadism**: Leydig cell dysfunction can lead to hypogonadism, a condition characterized by low testosterone levels, which can cause symptoms such as infertility, erectile dysfunction, and mood changes. 2. **Testicular Cancer**: Leydig cell tumors are a type of testicular cancer, which can be aggressive and require prompt treatment. 3. **Hormonal Imbalance**: Leydig cell dysfunction can lead to hormonal imbalances, including hypogonadism, which can have significant effects on male reproductive and development processes. 4. **Androgen Therapy**: Leydig cells play a crucial role in androgen therapy, which is used to treat conditions such as androgen deficiency and prostate cancer. 5. **Research Implications**: Understanding the biology of Leydig cells can provide insights into the development of new treatments for male reproductive disorders and hormonal imbalances. In conclusion, the Leydig cell is a unique cell type that plays a crucial role in male reproductive and development processes. Its function is tightly regulated by various signaling pathways, and its dysfunction can lead to significant clinical consequences. Further research on the biology of Leydig cells can provide valuable insights into the development of new treatments for male reproductive disorders and hormonal imbalances.