Details for: CL0000216

Cell ID: CL0000216

Cell Name: Sertoli cell

Marker Score Threshold: 5931
(Derived using integrated single-cell and genomic data)

Description: A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 3.86
    Ensembl ID: ENSG00000118137
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.64
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.61
    Ensembl ID: ENSG00000184009
  • Gene Symbol: AMH (ENSG00000104899)
    Fold Change: 3.49
    Ensembl ID: ENSG00000104899
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 3.44
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.38
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.25
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.23
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.21
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 3.01
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.96
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.87
    Ensembl ID: ENSG00000149925
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.86
    Ensembl ID: ENSG00000169100
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.84
    Ensembl ID: ENSG00000134825
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.73
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.71
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.64
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 2.61
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.56
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.52
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.47
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.44
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.43
    Ensembl ID: ENSG00000172270
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.41
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.37
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.36
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.21
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.2
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.19
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.15
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.13
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.09
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 2.09
    Ensembl ID: ENSG00000118971
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.07
    Ensembl ID: ENSG00000168374
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.04
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.04
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2.04
    Ensembl ID: ENSG00000197894
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.97
    Ensembl ID: ENSG00000160014
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.92
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.9
    Ensembl ID: ENSG00000085224
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.89
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.88
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.86
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.85
    Ensembl ID: ENSG00000165092
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.83
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.79
    Ensembl ID: ENSG00000077549
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.78
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.78
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.77
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.76
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.74
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.74
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.72
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.71
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.69
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.68
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.65
    Ensembl ID: ENSG00000159199
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.65
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.64
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.57
    Ensembl ID: ENSG00000128272
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.57
    Ensembl ID: ENSG00000183255
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.57
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.53
    Ensembl ID: ENSG00000138175
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.52
    Ensembl ID: ENSG00000108561
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 1.5
    Ensembl ID: ENSG00000135409
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.5
    Ensembl ID: ENSG00000100823
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.49
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.45
    Ensembl ID: ENSG00000167601
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.44
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.4
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.4
    Ensembl ID: ENSG00000140836
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.39
    Ensembl ID: ENSG00000128595
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.31
    Ensembl ID: ENSG00000115307
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.31
    Ensembl ID: ENSG00000149257
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196961
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.29
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.26
    Ensembl ID: ENSG00000174437
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.24
    Ensembl ID: ENSG00000127837
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.22
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.18
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.16
    Ensembl ID: ENSG00000105552
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.16
    Ensembl ID: ENSG00000004455
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.12
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.11
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.11
    Ensembl ID: ENSG00000126247
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.11
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.11
    Ensembl ID: ENSG00000165527
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.09
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.08
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.08
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.07
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.06
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.06
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.04
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.02
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: N/A
    Ensembl ID: ENSG00000176171
Hovered Details

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Hovered Details

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**Key Characteristics** The Sertoli cell is characterized by the following key features: 1. **Location**: The Sertoli cell is found in the seminiferous tubules of the testes. 2. **Structure**: The Sertoli cell has a unique structure, with tight junctions with the spermatogonia and spermatocytes, forming a blood-testis barrier. 3. **Function**: The Sertoli cell provides nutrients, hormones, and protection to the developing male germ cells. 4. **Secretion**: The Sertoli cell secretes androgen-binding protein, which helps regulate the levels of androgens in the testes. 5. **Gene Expression**: The Sertoli cell expresses a range of genes involved in lipid metabolism, cholesterol homeostasis, and androgen regulation. **Clinical Significance** The Sertoli cell plays a crucial role in male fertility, and dysfunction of these cells can lead to various reproductive disorders. Some of the clinical significance of the Sertoli cell includes: 1. **Male Infertility**: Dysfunction of the Sertoli cell can lead to male infertility, characterized by reduced sperm count, motility, and morphology. 2. **Testicular Cancer**: The Sertoli cell is also involved in the development of testicular cancer, particularly Sertoli cell tumors. 3. **Androgen Regulation**: The Sertoli cell plays a critical role in regulating androgen levels in the testes, and dysfunction of these cells can lead to androgen deficiency or excess. 4. **Lipid Metabolism**: The Sertoli cell is involved in lipid metabolism, and dysfunction of these cells can lead to lipid disorders, such as hyperlipidemia. In conclusion, the Sertoli cell is a critical component of the male reproductive system, and dysfunction of these cells can lead to various reproductive disorders. Further research is needed to understand the complex mechanisms involved in Sertoli cell function and to develop effective treatments for related disorders.