Details for: CL0000233

Cell ID: CL0000233

Cell Name: platelet

Marker Score Threshold: 453
(Derived using integrated single-cell and genomic data)

Description: A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.

Synonyms: anucleate thrombocyte, blood platelet, enucleate thrombocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.1
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.89
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.12
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.99
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.83
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.71
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.7
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.61
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.54
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.52
    Ensembl ID: ENSG00000143761
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.49
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.43
    Ensembl ID: ENSG00000077549
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.41
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.4
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 2.37
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.22
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.2
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.11
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 2.03
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.96
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.93
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.9
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.89
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.87
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.8
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.78
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.73
    Ensembl ID: ENSG00000005022
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.73
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.72
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.71
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.7
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.69
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.67
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.65
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.64
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.61
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.61
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.6
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.57
    Ensembl ID: ENSG00000153113
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.57
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.56
    Ensembl ID: ENSG00000177697
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.54
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.54
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.54
    Ensembl ID: ENSG00000019582
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.5
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.47
    Ensembl ID: ENSG00000196776
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.43
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.42
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.4
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.4
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.39
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.39
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.37
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.36
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.35
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.34
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.32
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.3
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.28
    Ensembl ID: ENSG00000130402
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.28
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.28
    Ensembl ID: ENSG00000072110
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.26
    Ensembl ID: ENSG00000108561
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.23
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.22
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.21
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.2
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.2
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.19
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.19
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.18
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.17
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CAPN1 (ENSG00000014216)
    Fold Change: 1.17
    Ensembl ID: ENSG00000014216
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.16
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.16
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.15
    Ensembl ID: ENSG00000126247
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.14
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.14
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.14
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.14
    Ensembl ID: ENSG00000134480
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.13
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.13
    Ensembl ID: ENSG00000124762
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.12
    Ensembl ID: ENSG00000140299
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.11
    Ensembl ID: ENSG00000130303
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.11
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.11
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.1
    Ensembl ID: ENSG00000164615
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.09
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.04
    Ensembl ID: ENSG00000110651
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.03
    Ensembl ID: ENSG00000142599
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197894
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.02
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.01
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.01
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.01
    Ensembl ID: ENSG00000172216
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Non-nucleated, disk-shaped cells**: Platelets are formed by the extrusion of megakaryocytes, which are nucleated cells that produce platelets. 2. **Blood coagulation**: Platelets play a crucial role in blood coagulation, enabling the formation of a platelet plug that stops bleeding when a blood vessel is injured. 3. **Antigen presentation**: Platelets can present antigens to T-cells, which is important for immune responses. 4. **Cytokine signaling**: Platelets can produce cytokines, which are signaling molecules that coordinate immune responses. 5. **Adhesion and aggregation**: Platelets can adhere to and aggregate with other platelets, forming a platelet plug that stops bleeding. **Clinical Significance** 1. **Thrombocytopenia**: A low platelet count can increase the risk of bleeding and thrombotic events. 2. **Thrombosis**: High platelet counts can increase the risk of thrombotic events, such as heart attacks and strokes. 3. **Immune responses**: Platelets play a crucial role in immune responses, including antigen presentation and cytokine signaling. 4. **Infection**: Platelets can modulate the immune response to infections, including HIV and tuberculosis. 5. **Cancer**: Platelets can contribute to cancer progression and metastasis. **Pathways/Ontology** 1. **Adaptive immune system**: Platelets participate in antigen presentation and cytokine signaling, which are important for adaptive immune responses. 2. **Amyloid fiber formation**: Platelets can form amyloid fibers, which are associated with various diseases, including Alzheimer's disease and amyloidosis. 3. **Amyloid fibril formation**: Platelets can form amyloid fibrils, which are associated with various diseases, including Alzheimer's disease and amyloidosis. 4. **Antigen processing and presentation**: Platelets can process and present antigens to T-cells, which is important for immune responses. 5. **Cytokine signaling in immune system**: Platelets can produce cytokines, which are signaling molecules that coordinate immune responses. In conclusion, platelets are non-nucleated, disk-shaped cells that play a crucial role in blood coagulation and immune responses. They participate in various pathways, including adaptive immune system, amyloid fiber formation, and antigen processing and presentation. Understanding the key characteristics, clinical significance, and pathways/ontology associated with platelets is important for the diagnosis and treatment of various diseases.