Details for: CL0000234

Cell ID: CL0000234

Cell Name: phagocyte

Marker Score Threshold: 331
(Derived using integrated single-cell and genomic data)

Description: Any cell capable of ingesting particulate matter via phagocytosis.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.47
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.39
    Ensembl ID: ENSG00000099622
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.31
    Ensembl ID: ENSG00000166710
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.25
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.16
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.16
    Ensembl ID: ENSG00000198668
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.15
    Ensembl ID: ENSG00000131143
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.14
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.08
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.99
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.99
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.86
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.83
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.83
    Ensembl ID: ENSG00000122545
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.8
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.78
    Ensembl ID: ENSG00000179218
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.75
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.71
    Ensembl ID: ENSG00000126267
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.7
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.7
    Ensembl ID: ENSG00000143761
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.69
    Ensembl ID: ENSG00000135940
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.68
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.67
    Ensembl ID: ENSG00000077549
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.66
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.66
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.63
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.59
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.58
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.58
    Ensembl ID: ENSG00000154723
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.58
    Ensembl ID: ENSG00000067082
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.56
    Ensembl ID: ENSG00000172270
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.53
    Ensembl ID: ENSG00000176340
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.51
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.51
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.48
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.48
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.45
    Ensembl ID: ENSG00000130402
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.45
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.45
    Ensembl ID: ENSG00000135404
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.45
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.44
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.43
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.42
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.42
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.42
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.39
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.39
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.38
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.35
    Ensembl ID: ENSG00000152518
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.35
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.34
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.34
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.33
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.32
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.31
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.29
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.29
    Ensembl ID: ENSG00000122705
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.28
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.27
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.26
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.23
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.21
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.2
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.19
    Ensembl ID: ENSG00000116459
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.18
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.16
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.16
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160710
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.15
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.14
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.14
    Ensembl ID: ENSG00000138279
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.12
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.1
    Ensembl ID: ENSG00000112576
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.1
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.1
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.09
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.09
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.08
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.06
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.06
    Ensembl ID: ENSG00000165527
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.04
    Ensembl ID: ENSG00000074201
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.04
    Ensembl ID: ENSG00000122218
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.04
    Ensembl ID: ENSG00000141367
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143799
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.03
    Ensembl ID: ENSG00000111642
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.01
    Ensembl ID: ENSG00000105254
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149311
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.01
    Ensembl ID: ENSG00000134480
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CSNK1D (ENSG00000141551)
    Fold Change: 1
    Ensembl ID: ENSG00000141551
  • Gene Symbol: COPB1 (ENSG00000129083)
    Fold Change: 1
    Ensembl ID: ENSG00000129083
Hovered Details

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Hovered Details

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**Key Characteristics** Phagocytes exhibit several key characteristics that enable them to perform their functions effectively: 1. **Phagocytosis**: Phagocytes are capable of engulfing and digesting foreign particles, including bacteria, dead cells, and debris. 2. **Actin cytoskeleton**: The actin cytoskeleton plays a crucial role in phagocytosis, providing the necessary structure for the formation of the phagocytic cup and the movement of the phagocyte. 3. **Adherens junctions**: Adherens junctions are essential for the formation of the phagocytic cup, allowing the phagocyte to adhere to the target particle. 4. **Cytoskeleton organization**: The organization of the cytoskeleton is critical for the movement and migration of phagocytes. 5. **Signaling pathways**: Phagocytes are capable of activating various signaling pathways, including the MAPK and PI3K/AKT pathways, which regulate cellular processes such as proliferation, differentiation, and survival. **Clinical Significance** Phagocytes play a vital role in maintaining immune homeostasis and preventing disease. Dysregulation of phagocytic function has been implicated in various diseases, including: 1. **Infectious diseases**: Phagocytic dysfunction can lead to increased susceptibility to infections, as the immune system is unable to effectively clear pathogens. 2. **Autoimmune diseases**: Phagocytic dysfunction can also contribute to autoimmune diseases, such as rheumatoid arthritis and lupus, by allowing autoantigens to escape immune surveillance. 3. **Cancer**: Phagocytic dysfunction can facilitate tumor growth and metastasis by allowing cancer cells to evade immune surveillance. 4. **Neurodegenerative diseases**: Phagocytic dysfunction has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, by contributing to the accumulation of toxic proteins. In conclusion, phagocytes are a crucial component of the innate immune system, and their dysfunction can have significant clinical implications. Understanding the mechanisms of phagocytosis and the regulation of phagocytic function is essential for the development of novel therapeutic strategies for the treatment of diseases characterized by impaired phagocytic function.