Details for: CL0000322

Cell ID: CL0000322

Cell Name: pneumocyte

Marker Score Threshold: 1,607
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates.

Synonyms: alveolar epithelial cell, alveolus of lung epithelial cell, epithelial cell of alveolus of lung, pneumocyte, pneumonocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: MGST1 (ENSG00000008394)
    Fold Change: 3.18
    Ensembl ID: ENSG00000008394
  • Gene Symbol: CYB5A (ENSG00000166347)
    Fold Change: 3.16
    Ensembl ID: ENSG00000166347
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 3.09
    Ensembl ID: ENSG00000156508
  • Gene Symbol: DHCR24 (ENSG00000116133)
    Fold Change: 3.09
    Ensembl ID: ENSG00000116133
  • Gene Symbol: CTSH (ENSG00000103811)
    Fold Change: 3.09
    Ensembl ID: ENSG00000103811
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 3.09
    Ensembl ID: ENSG00000087086
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 3.09
    Ensembl ID: ENSG00000167996
  • Gene Symbol: GSTP1 (ENSG00000084207)
    Fold Change: 3.08
    Ensembl ID: ENSG00000084207
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.08
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.07
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 3.07
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.07
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 3.06
    Ensembl ID: ENSG00000160213
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 3.04
    Ensembl ID: ENSG00000127184
  • Gene Symbol: HLA DRA (ENSG00000204287)
    Fold Change: 3.03
    Ensembl ID: ENSG00000204287
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 3.02
    Ensembl ID: ENSG00000149806
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 3.02
    Ensembl ID: ENSG00000155368
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.02
    Ensembl ID: ENSG00000124172
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 3
    Ensembl ID: ENSG00000163041
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.98
    Ensembl ID: ENSG00000143933
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.98
    Ensembl ID: ENSG00000132475
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.97
    Ensembl ID: ENSG00000168028
  • Gene Symbol: FABP5 (ENSG00000164687)
    Fold Change: 2.96
    Ensembl ID: ENSG00000164687
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.95
    Ensembl ID: ENSG00000104529
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.95
    Ensembl ID: ENSG00000134825
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.95
    Ensembl ID: ENSG00000112695
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.94
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.94
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.93
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.93
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.92
    Ensembl ID: ENSG00000169020
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.92
    Ensembl ID: ENSG00000189403
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 2.92
    Ensembl ID: ENSG00000085063
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.91
    Ensembl ID: ENSG00000131143
  • Gene Symbol: GNG5 (ENSG00000174021)
    Fold Change: 2.9
    Ensembl ID: ENSG00000174021
  • Gene Symbol: HNRNPA1 (ENSG00000135486)
    Fold Change: 2.89
    Ensembl ID: ENSG00000135486
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.89
    Ensembl ID: ENSG00000167658
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.88
    Ensembl ID: ENSG00000169567
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.88
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.87
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.87
    Ensembl ID: ENSG00000126267
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.87
    Ensembl ID: ENSG00000080824
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 2.87
    Ensembl ID: ENSG00000074800
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.87
    Ensembl ID: ENSG00000111640
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.87
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 2.86
    Ensembl ID: ENSG00000167972
  • Gene Symbol: FKBP2 (ENSG00000173486)
    Fold Change: 2.86
    Ensembl ID: ENSG00000173486
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.84
    Ensembl ID: ENSG00000084234
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2.84
    Ensembl ID: ENSG00000234745
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.84
    Ensembl ID: ENSG00000114942
  • Gene Symbol: HLA DRB1 (ENSG00000196126)
    Fold Change: 2.84
    Ensembl ID: ENSG00000196126
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.83
    Ensembl ID: ENSG00000135390
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.82
    Ensembl ID: ENSG00000096384
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.82
    Ensembl ID: ENSG00000163399
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 2.82
    Ensembl ID: ENSG00000125730
  • Gene Symbol: GPX1 (ENSG00000233276)
    Fold Change: 2.82
    Ensembl ID: ENSG00000233276
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.81
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 2.8
    Ensembl ID: ENSG00000176340
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 2.79
    Ensembl ID: ENSG00000165272
  • Gene Symbol: HSPE1 (ENSG00000115541)
    Fold Change: 2.78
    Ensembl ID: ENSG00000115541
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 2.78
    Ensembl ID: ENSG00000131174
  • Gene Symbol: KRT18 (ENSG00000111057)
    Fold Change: 2.78
    Ensembl ID: ENSG00000111057
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.77
    Ensembl ID: ENSG00000167468
  • Gene Symbol: LDHB (ENSG00000111716)
    Fold Change: 2.77
    Ensembl ID: ENSG00000111716
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 2.76
    Ensembl ID: ENSG00000106992
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.74
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 2.74
    Ensembl ID: ENSG00000221869
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.73
    Ensembl ID: ENSG00000122566
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.72
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.72
    Ensembl ID: ENSG00000104763
  • Gene Symbol: LDHA (ENSG00000134333)
    Fold Change: 2.7
    Ensembl ID: ENSG00000134333
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.7
    Ensembl ID: ENSG00000179218
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.69
    Ensembl ID: ENSG00000135940
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.68
    Ensembl ID: ENSG00000067560
  • Gene Symbol: HLA DRB5 (ENSG00000198502)
    Fold Change: 2.68
    Ensembl ID: ENSG00000198502
  • Gene Symbol: LGALS3 (ENSG00000131981)
    Fold Change: 2.68
    Ensembl ID: ENSG00000131981
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.68
    Ensembl ID: ENSG00000090013
  • Gene Symbol: KRT8 (ENSG00000170421)
    Fold Change: 2.67
    Ensembl ID: ENSG00000170421
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.65
    Ensembl ID: ENSG00000154723
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.65
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CLDN7 (ENSG00000181885)
    Fold Change: 2.65
    Ensembl ID: ENSG00000181885
  • Gene Symbol: HLA DPA1 (ENSG00000231389)
    Fold Change: 2.65
    Ensembl ID: ENSG00000231389
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 2.64
    Ensembl ID: ENSG00000143420
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 2.63
    Ensembl ID: ENSG00000206503
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 2.63
    Ensembl ID: ENSG00000204525
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.62
    Ensembl ID: ENSG00000108654
  • Gene Symbol: HLA DPB1 (ENSG00000223865)
    Fold Change: 2.59
    Ensembl ID: ENSG00000223865
  • Gene Symbol: DDT (ENSG00000099977)
    Fold Change: 2.58
    Ensembl ID: ENSG00000099977
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.58
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.57
    Ensembl ID: ENSG00000099622
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 2.57
    Ensembl ID: ENSG00000106211
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 2.57
    Ensembl ID: ENSG00000129562
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 2.56
    Ensembl ID: ENSG00000100632
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.54
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.54
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ID1 (ENSG00000125968)
    Fold Change: 2.53
    Ensembl ID: ENSG00000125968
  • Gene Symbol: ALPL (ENSG00000162551)
    Fold Change: 2.53
    Ensembl ID: ENSG00000162551
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.53
    Ensembl ID: ENSG00000154518
  • Gene Symbol: HSBP1 (ENSG00000230989)
    Fold Change: 2.53
    Ensembl ID: ENSG00000230989
  • Gene Symbol: MGST3 (ENSG00000143198)
    Fold Change: 2.52
    Ensembl ID: ENSG00000143198

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in pneumocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in pneumocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Epithelial cell type * Lines the peripheral gas exchange region of the lungs * High surface area for gas exchange * Microvilli for increased surface area * Involved in metabolism, immune responses, and cell signaling * Express genes involved in detoxification, antioxidant defense, and immune response * Have a distinctive cytoskeletal structure, including actin filaments and microtubules * Can differentiate into types II pneumocytes, which produce surfactant, or type I pneumocytes, which are involved in gas exchange **Clinical Significance** Pneumocytes are involved in various lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, and pneumonia. Understanding the function and regulation of pneumocytes is essential for developing effective treatments for these diseases. Additionally, pneumocytes play a crucial role in maintaining lung homeostasis, and their dysfunction can lead to various respiratory disorders. **Pathways and Ontology** Pneumocytes are involved in various cellular processes, including: * Biological oxidations and cellular oxidant detoxification (GSTP1) * Immune system and innate immune system (CTSH, FTL, and GSTP1) * Metabolism and energy production (EEF1A1 and MGST1) * Cell signaling and response to stimuli (EEF1A1 and MGST1) * Detoxification and antioxidant defense (GSTP1) * Cell growth and proliferation (CTSH and GSTP1) **Genes and Gene Products** * MGST1: Glutathione S-transferase 1, involved in detoxification and antioxidant defense * CYB5A: Cytochrome-c oxidase, involved in electron transport and energy production * EEF1A1: Eukaryotic translation elongation factor 1 alpha 1, involved in protein synthesis and cell growth * DHCR24: Delta-24(24-1) sterol reductase, involved in cholesterol biosynthesis * CTSH: Cathepsin H, involved in protein degradation and immune response * FTL: Ferroportin, involved in iron homeostasis and immune response * GSTP1: Glutathione S-transferase pi 1, involved in detoxification and antioxidant defense **References** * [1] "Pneumocytes: Structure, Function, and Regulation" (Journal of Lung Biology, 2020) * [2] "The Role of Pneumocytes in Lung Disease" (American Journal of Respiratory and Critical Care Medicine, 2019) * [3] "Pneumocyte Gene Expression and Lung Development" (Developmental Biology, 2018) Note: The references provided are fictional and for demonstration purposes only.