CL0000359 - vascular associated smooth muscle cell details

Details for: CL0000359

Cell ID: CL0000359

Cell Name: vascular associated smooth muscle cell

Marker Score Threshold: 459
(Derived using integrated single-cell and genomic data)

Description: A smooth muscle cell associated with the vasculature.

Synonyms: VSMC, vascular smooth muscle cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 3.38
Ensembl ID: ENSG00000169100
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 3.23
Ensembl ID: ENSG00000075624
Gene Symbol: B2M (ENSG00000166710)
Fold Change: 3.07
Ensembl ID: ENSG00000166710
Gene Symbol: AFP (ENSG00000081051)
Fold Change: 3.06
Ensembl ID: ENSG00000081051
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 2.88
Ensembl ID: ENSG00000145741
Gene Symbol: CALM2 (ENSG00000143933)
Fold Change: 2.8
Ensembl ID: ENSG00000143933
Gene Symbol: BTG1 (ENSG00000133639)
Fold Change: 2.76
Ensembl ID: ENSG00000133639
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 2.76
Ensembl ID: ENSG00000184009
Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 2.65
Ensembl ID: ENSG00000198668
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 2.6
Ensembl ID: ENSG00000135390
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 2.57
Ensembl ID: ENSG00000124172
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 2.51
Ensembl ID: ENSG00000067560
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 2.29
Ensembl ID: ENSG00000005022
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 2.2
Ensembl ID: ENSG00000185650
Gene Symbol: TMEM258 (ENSG00000134825)
Fold Change: 2.2
Ensembl ID: ENSG00000134825
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 2.18
Ensembl ID: ENSG00000154723
Gene Symbol: CALR (ENSG00000179218)
Fold Change: 2.18
Ensembl ID: ENSG00000179218
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 2.17
Ensembl ID: ENSG00000169020
Gene Symbol: CAPZB (ENSG00000077549)
Fold Change: 2.17
Ensembl ID: ENSG00000077549
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 2.11
Ensembl ID: ENSG00000154518
Gene Symbol: ARF1 (ENSG00000143761)
Fold Change: 2.05
Ensembl ID: ENSG00000143761
Gene Symbol: ATF4 (ENSG00000128272)
Fold Change: 2.02
Ensembl ID: ENSG00000128272
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 2.01
Ensembl ID: ENSG00000099624
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 2
Ensembl ID: ENSG00000110955
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 1.9
Ensembl ID: ENSG00000152234
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.87
Ensembl ID: ENSG00000172270
Gene Symbol: ATP1B3 (ENSG00000069849)
Fold Change: 1.87
Ensembl ID: ENSG00000069849
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.85
Ensembl ID: ENSG00000164111
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 1.83
Ensembl ID: ENSG00000165629
Gene Symbol: APRT (ENSG00000198931)
Fold Change: 1.79
Ensembl ID: ENSG00000198931
Gene Symbol: ANXA2 (ENSG00000182718)
Fold Change: 1.78
Ensembl ID: ENSG00000182718
Gene Symbol: ZFP36L2 (ENSG00000152518)
Fold Change: 1.77
Ensembl ID: ENSG00000152518
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 1.73
Ensembl ID: ENSG00000116459
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 1.72
Ensembl ID: ENSG00000117410
Gene Symbol: CANX (ENSG00000127022)
Fold Change: 1.7
Ensembl ID: ENSG00000127022
Gene Symbol: ATP5MC1 (ENSG00000159199)
Fold Change: 1.69
Ensembl ID: ENSG00000159199
Gene Symbol: CALM3 (ENSG00000160014)
Fold Change: 1.67
Ensembl ID: ENSG00000160014
Gene Symbol: CAST (ENSG00000153113)
Fold Change: 1.67
Ensembl ID: ENSG00000153113
Gene Symbol: CALD1 (ENSG00000122786)
Fold Change: 1.67
Ensembl ID: ENSG00000122786
Gene Symbol: ARHGDIB (ENSG00000111348)
Fold Change: 1.67
Ensembl ID: ENSG00000111348
Gene Symbol: ALDOA (ENSG00000149925)
Fold Change: 1.67
Ensembl ID: ENSG00000149925
Gene Symbol: RHOB (ENSG00000143878)
Fold Change: 1.63
Ensembl ID: ENSG00000143878
Gene Symbol: ARF4 (ENSG00000168374)
Fold Change: 1.62
Ensembl ID: ENSG00000168374
Gene Symbol: ATP1A1 (ENSG00000163399)
Fold Change: 1.59
Ensembl ID: ENSG00000163399
Gene Symbol: ARHGDIA (ENSG00000141522)
Fold Change: 1.58
Ensembl ID: ENSG00000141522
Gene Symbol: APEX1 (ENSG00000100823)
Fold Change: 1.58
Ensembl ID: ENSG00000100823
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.57
Ensembl ID: ENSG00000130402
Gene Symbol: CAPZA2 (ENSG00000198898)
Fold Change: 1.56
Ensembl ID: ENSG00000198898
Gene Symbol: ATRX (ENSG00000085224)
Fold Change: 1.55
Ensembl ID: ENSG00000085224
Gene Symbol: ANXA11 (ENSG00000122359)
Fold Change: 1.55
Ensembl ID: ENSG00000122359
Gene Symbol: CCT6A (ENSG00000146731)
Fold Change: 1.54
Ensembl ID: ENSG00000146731
Gene Symbol: AMD1 (ENSG00000123505)
Fold Change: 1.52
Ensembl ID: ENSG00000123505
Gene Symbol: APP (ENSG00000142192)
Fold Change: 1.52
Ensembl ID: ENSG00000142192
Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 1.52
Ensembl ID: ENSG00000241837
Gene Symbol: TSPO (ENSG00000100300)
Fold Change: 1.51
Ensembl ID: ENSG00000100300
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 1.48
Ensembl ID: ENSG00000084234
Gene Symbol: ASAH1 (ENSG00000104763)
Fold Change: 1.48
Ensembl ID: ENSG00000104763
Gene Symbol: BNIP3L (ENSG00000104765)
Fold Change: 1.48
Ensembl ID: ENSG00000104765
Gene Symbol: C1QBP (ENSG00000108561)
Fold Change: 1.47
Ensembl ID: ENSG00000108561
Gene Symbol: ATOX1 (ENSG00000177556)
Fold Change: 1.46
Ensembl ID: ENSG00000177556
Gene Symbol: ARF5 (ENSG00000004059)
Fold Change: 1.45
Ensembl ID: ENSG00000004059
Gene Symbol: ANXA1 (ENSG00000135046)
Fold Change: 1.42
Ensembl ID: ENSG00000135046
Gene Symbol: BST2 (ENSG00000130303)
Fold Change: 1.42
Ensembl ID: ENSG00000130303
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 1.4
Ensembl ID: ENSG00000072778
Gene Symbol: BAG1 (ENSG00000107262)
Fold Change: 1.39
Ensembl ID: ENSG00000107262
Gene Symbol: CD9 (ENSG00000010278)
Fold Change: 1.38
Ensembl ID: ENSG00000010278
Gene Symbol: CD44 (ENSG00000026508)
Fold Change: 1.37
Ensembl ID: ENSG00000026508
Gene Symbol: TLE5 (ENSG00000104964)
Fold Change: 1.36
Ensembl ID: ENSG00000104964
Gene Symbol: CAMLG (ENSG00000164615)
Fold Change: 1.31
Ensembl ID: ENSG00000164615
Gene Symbol: ZFHX3 (ENSG00000140836)
Fold Change: 1.3
Ensembl ID: ENSG00000140836
Gene Symbol: ATF3 (ENSG00000162772)
Fold Change: 1.3
Ensembl ID: ENSG00000162772
Gene Symbol: RHOC (ENSG00000155366)
Fold Change: 1.29
Ensembl ID: ENSG00000155366
Gene Symbol: CAPZA1 (ENSG00000116489)
Fold Change: 1.29
Ensembl ID: ENSG00000116489
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.28
Ensembl ID: ENSG00000138279
Gene Symbol: CCNH (ENSG00000134480)
Fold Change: 1.26
Ensembl ID: ENSG00000134480
Gene Symbol: AUP1 (ENSG00000115307)
Fold Change: 1.24
Ensembl ID: ENSG00000115307
Gene Symbol: BAX (ENSG00000087088)
Fold Change: 1.24
Ensembl ID: ENSG00000087088
Gene Symbol: ACP1 (ENSG00000143727)
Fold Change: 1.23
Ensembl ID: ENSG00000143727
Gene Symbol: ACTN1 (ENSG00000072110)
Fold Change: 1.21
Ensembl ID: ENSG00000072110
Gene Symbol: DST (ENSG00000151914)
Fold Change: 1.19
Ensembl ID: ENSG00000151914
Gene Symbol: ARF6 (ENSG00000165527)
Fold Change: 1.18
Ensembl ID: ENSG00000165527
Gene Symbol: ADH5 (ENSG00000197894)
Fold Change: 1.16
Ensembl ID: ENSG00000197894
Gene Symbol: ATP2A2 (ENSG00000174437)
Fold Change: 1.15
Ensembl ID: ENSG00000174437
Gene Symbol: ADD1 (ENSG00000087274)
Fold Change: 1.13
Ensembl ID: ENSG00000087274
Gene Symbol: PTTG1IP (ENSG00000183255)
Fold Change: 1.12
Ensembl ID: ENSG00000183255
Gene Symbol: AAMP (ENSG00000127837)
Fold Change: 1.11
Ensembl ID: ENSG00000127837
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.09
Ensembl ID: ENSG00000160710
Gene Symbol: RERE (ENSG00000142599)
Fold Change: 1.09
Ensembl ID: ENSG00000142599
Gene Symbol: CAPNS1 (ENSG00000126247)
Fold Change: 1.09
Ensembl ID: ENSG00000126247
Gene Symbol: RND3 (ENSG00000115963)
Fold Change: 1.08
Ensembl ID: ENSG00000115963
Gene Symbol: ATP6V0C (ENSG00000185883)
Fold Change: 1.08
Ensembl ID: ENSG00000185883
Gene Symbol: ATP6V1E1 (ENSG00000131100)
Fold Change: 1.08
Ensembl ID: ENSG00000131100
Gene Symbol: CAPN2 (ENSG00000162909)
Fold Change: 1.08
Ensembl ID: ENSG00000162909
Gene Symbol: APOE (ENSG00000130203)
Fold Change: 1.06
Ensembl ID: ENSG00000130203
Gene Symbol: BNIP2 (ENSG00000140299)
Fold Change: 1.03
Ensembl ID: ENSG00000140299
Gene Symbol: PARP1 (ENSG00000143799)
Fold Change: 1.03
Ensembl ID: ENSG00000143799
Gene Symbol: GET3 (ENSG00000198356)
Fold Change: 1.02
Ensembl ID: ENSG00000198356
Gene Symbol: CAT (ENSG00000121691)
Fold Change: 1.02
Ensembl ID: ENSG00000121691
Gene Symbol: BAD (ENSG00000002330)
Fold Change: 1.01
Ensembl ID: ENSG00000002330
Gene Symbol: CCND3 (ENSG00000112576)
Fold Change: 1.01
Ensembl ID: ENSG00000112576

Gene representation (1608)
Gene/Pathway representation (1608)

Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cell Type**: Vascular associated smooth muscle cell (VSMC) 2. **Gene Symbol**: SLC25A6 3. **Associated Processes**: Apoptotic process, Atp:adp antiporter activity, disease, HIV infection, host interactions of HIV factors, infectious disease, influenza infection, influenza virus induced apoptosis, interactions of VPR with host cellular proteins 4. **Cellular Functions**: Maintaining vascular tone and blood pressure, regulating cell growth and differentiation, responding to extracellular stimuli 5. **Cellular Structure**: Smooth muscle cell, cytoplasm, nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus **Clinical Significance** 1. **Vascular Diseases**: VSMCs play a crucial role in the development and progression of vascular diseases, such as atherosclerosis, hypertension, and restenosis. 2. **Cardiovascular Diseases**: VSMCs are involved in the pathogenesis of cardiovascular diseases, including myocardial infarction, stroke, and cardiac arrhythmias. 3. **Cancer Metastasis**: VSMCs can contribute to cancer metastasis by facilitating the migration and invasion of cancer cells. 4. **Infectious Diseases**: VSMCs can interact with viral factors, such as HIV and influenza virus, and play a role in the pathogenesis of infectious diseases. 5. **Therapeutic Target**: VSMCs are potential therapeutic targets for the treatment of vascular and cardiovascular diseases. **Pathways/Ontology** 1. **Apoptotic Process**: VSMCs are involved in the regulation of apoptotic process, which is essential for maintaining vascular homeostasis. 2. **Atp:adp Antiporter Activity**: VSMCs regulate Atp:adp antiporter activity, which is crucial for maintaining energy homeostasis in cells. 3. **Disease**: VSMCs are associated with various diseases, including vascular diseases, cardiovascular diseases, and cancer metastasis. 4. **HIV Infection**: VSMCs interact with HIV factors and play a role in the pathogenesis of HIV infection. 5. **Host Interactions**: VSMCs interact with various host cellular proteins and play a role in host interactions. **Gene Symbol and Ensembl ID** 1. **Gene Symbol**: SLC25A6 2. **Ensembl ID**: ENSG00000169100 **Pathways/Ontology (ActB)** 1. **Actin Cytoskeleton**: ActB is involved in the regulation of actin cytoskeleton dynamics, which is essential for cell shape, movement, and division. 2. **Apical Junction Complex**: ActB interacts with various proteins involved in apical junction complex assembly and function. 3. **Cell-Cell Junction**: ActB regulates cell-cell junction organization and function, which is essential for maintaining tissue structure and function. 4. **Cytoskeleton**: ActB is involved in the regulation of cytoskeleton dynamics, which is crucial for maintaining cell shape, movement, and division. 5. **Disease**: ActB is associated with various diseases, including cardiovascular diseases and cancer metastasis. **Gene Symbol and Ensembl ID (B2M)** 1. **Gene Symbol**: B2M 2. **Ensembl ID**: ENSG00000166710

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.