Details for: CL0000362

Cell ID: CL0000362

Cell Name: epidermal cell

Marker Score Threshold: 281
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell of the integument (the outer layer of an organism).

Synonyms: cell of epidermis, epithelial cell of skin

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.38
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.36
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.08
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.05
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.94
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.91
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.79
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.73
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.61
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.61
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.47
    Ensembl ID: ENSG00000135404
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.42
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.38
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.36
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.27
    Ensembl ID: ENSG00000122545
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.24
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.23
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.19
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.17
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.16
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.15
    Ensembl ID: ENSG00000077549
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.12
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.06
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.99
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.96
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.93
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.87
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.84
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.84
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.83
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.75
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.74
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.71
    Ensembl ID: ENSG00000168374
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.69
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.68
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.68
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.67
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.65
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.64
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.64
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.61
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.57
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.55
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.54
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.53
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.53
    Ensembl ID: ENSG00000159199
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.51
    Ensembl ID: ENSG00000108561
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.5
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.48
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.46
    Ensembl ID: ENSG00000104763
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.41
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.4
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.39
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.37
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.36
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.35
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.35
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.35
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.35
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.35
    Ensembl ID: ENSG00000110651
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.33
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.33
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.33
    Ensembl ID: ENSG00000160710
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.3
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.3
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.28
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.27
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.25
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.23
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.23
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.23
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.22
    Ensembl ID: ENSG00000126247
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.21
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.2
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.19
    Ensembl ID: ENSG00000177556
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.19
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.18
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.18
    Ensembl ID: ENSG00000135046
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.15
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.15
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.15
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.12
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.11
    Ensembl ID: ENSG00000140299
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.11
    Ensembl ID: ENSG00000111642
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.07
    Ensembl ID: ENSG00000197043
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.07
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.06
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.04
    Ensembl ID: ENSG00000085063
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.03
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CDC5L (ENSG00000096401)
    Fold Change: 1.03
    Ensembl ID: ENSG00000096401
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.02
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.01
    Ensembl ID: ENSG00000113328
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1
    Ensembl ID: ENSG00000107262
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: N/A
    Ensembl ID: ENSG00000004455
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: N/A
    Ensembl ID: ENSG00000172216
Hovered Details

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Hovered Details

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**Key Characteristics** * **Epidermal Cell (CL0000362)** + Epithelial cell of the integument (outer layer of the skin) + Gene symbol: ACTB + Pathways/ontology: Actin cytoskeleton, Adherens junction, Apical protein localization, Cell-cell communication, Cell-cell junction, Cell-extracellular matrix interactions, Cytoskeleton, Cytoplasm, Dense body, Deubiquitination, Developmental biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers * **Beta-2 Microglobulin (B2M)** + Protein component of the MHC class I molecule + Gene symbol: B2M + Pathways/ontology: Adaptive immune system, Amyloid fiber formation, Amyloid fibril formation, Antigen presentation: folding, assembly and peptide loading of class I MHC, Antigen processing-cross presentation, Antigen processing and presentation of endogenous peptide antigen via MHC class I, Antigen processing and presentation of exogenous peptide antigen via MHC class II, Antigen processing and presentation of exogenous protein antigen via MHC class IB, tap-dependent, Bacterial infection pathways, Cellular response to iron(III) ion, Cellular response to iron ion, Cellular response to nicotine, Class I MHC mediated antigen processing & presentation, Cytokine signaling in immune system, Cytosol, Dap12 interactions, Dap12 signaling, Disease, Early endosome lumen, Early endosome membrane, Endoplasmic reticulum, Endoplasmic reticulum lumen, Endosomal/vacuolar pathway, Er-phagosome pathway, Er to Golgi transport vesicle membrane, External side of plasma membrane, Extracellular exosome, Extracellular region, Extracellular space, Focal adhesion, Golgi apparatus, Golgi membrane, Hfe-transferrin receptor complex, Hiv infection, Host interactions of hiv factors, Identical protein binding, Immune system, Immunoregulatory interactions between a lymphoid and a non-lymphoid cell, Infection with mycobacterium tuberculosis, Infectious disease, Innate immune system, Interferon gamma signaling, Interferon signaling, Intracellular iron ion homeostasis, Iron ion transport, Late endosome membrane, Learning or memory, Lysosomal membrane, Membrane, Metabolism of proteins, MHC class II protein complex, MHC class II protein complex binding, MHC class I peptide loading complex, MHC class I protein complex, Modulation by mtb of host immune system, Multicellular organismal-level iron ion homeostasis, Nef-mediated down modulation of cell surface receptors by recruiting them to clathrin adapters, Nef mediated downregulation of MHC class I complex cell surface expression, Negative regulation of epithelial cell proliferation, Negative regulation of forebrain neuron differentiation, Negative regulation of neurogenesis, Negative regulation of neuron projection development, Negative regulation of receptor binding, Neutrophil degranulation, Peptide antigen assembly with MHC class II protein complex, Peptide antigen assembly with MHC class... **Clinical Significance** * **Epidermal Cell (CL0000362)** + Plays a crucial role in the skin's barrier function and immune response + Involved in various cellular processes, including cell-cell communication, cell-extracellular matrix interactions, and cytoskeleton organization + Abnormalities in epidermal cells can lead to skin disorders, such as psoriasis, eczema, and skin cancer * **Beta-2 Microglobulin (B2M)** + Essential for the proper functioning of the MHC class I molecule + Involved in antigen presentation, immune response, and cellular processes, including endosomal/vacuolar pathway and intracellular iron ion homeostasis + Elevated levels of beta-2 microglobulin have been associated with various diseases, including multiple myeloma, lymphoma, and acquired immunodeficiency syndrome (AIDS) **Pathways/ontology** * **Epidermal Cell (CL0000362)** + Actin cytoskeleton + Adherens junction + Apical protein localization + Cell-cell communication + Cell-cell junction + Cell-extracellular matrix interactions + Cytoskeleton + Cytoplasm + Dense body + Deubiquitination + Developmental biology + Disease + Diseases of signal transduction by growth factor receptors and second messengers * **Beta-2 Microglobulin (B2M)** + Adaptive immune system + Amyloid fiber formation + Amyloid fibril formation + Antigen presentation: folding, assembly and peptide loading of class I MHC + Antigen processing-cross presentation + Antigen processing and presentation of endogenous peptide antigen via MHC class I + Antigen processing and presentation of exogenous peptide antigen via MHC class II + Antigen processing and presentation of exogenous protein antigen via MHC class IB, tap-dependent + Bacterial infection pathways + Cellular response to iron(III) ion + Cellular response to iron ion + Cellular response to nicotine + Class I MHC mediated antigen processing & presentation + Cytokine signaling in immune system + Cytosol + Dap12 interactions + Dap12 signaling + Disease + Early endosome lumen + Early endosome membrane + Endoplasmic reticulum + Endoplasmic reticulum lumen + Endosomal/vacuolar pathway + Er-phagosome pathway + Er to Golgi transport vesicle membrane + External side of plasma membrane + Extracellular exosome + Extracellular region + Extracellular space + Focal adhesion + Golgi apparatus + Golgi membrane + Hfe-transferrin receptor complex + Hiv infection + Host interactions of hiv factors + Identical protein binding + Immune system + Immunoregulatory interactions between a lymphoid and a non-lymphoid cell + Infection with mycobacterium tuberculosis + Infectious disease + Innate immune system + Interferon gamma signaling + Interferon signaling + Intracellular iron ion homeostasis + Iron ion transport + Late endosome membrane + Learning or memory + Lysosomal membrane + Membrane + Metabolism of proteins + MHC class II protein complex + MHC class II protein complex binding + MHC class I peptide loading complex + MHC class I protein complex + Modulation by mtb of host immune system + Multicellular organismal-level iron ion homeostasis + Nef-mediated down modulation of cell surface receptors by recruiting them to clathrin adapters + Nef mediated downregulation of MHC class I complex cell surface expression + Negative regulation of epithelial cell proliferation + Negative regulation of forebrain neuron differentiation + Negative regulation of neurogenesis + Negative regulation of neuron projection development + Negative regulation of receptor binding + Neutrophil degranulation + Peptide antigen assembly with MHC class II protein complex + Peptide antigen assembly with MHC class...