Details for: CL0000402

Cell ID: CL0000402

Cell Name: CNS interneuron

Marker Score Threshold: 481
(Derived using integrated single-cell and genomic data)

Description: An interneuron that has its cell body in a central nervous system.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 5.13
    Ensembl ID: ENSG00000153956
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 4.52
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 4.37
    Ensembl ID: ENSG00000169862
  • Gene Symbol: DACH1 (ENSG00000276644)
    Fold Change: 4.29
    Ensembl ID: ENSG00000276644
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 4.18
    Ensembl ID: ENSG00000066032
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.83
    Ensembl ID: ENSG00000142599
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 3.71
    Ensembl ID: ENSG00000151746
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 3.69
    Ensembl ID: ENSG00000168675
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.65
    Ensembl ID: ENSG00000151914
  • Gene Symbol: DGKB (ENSG00000136267)
    Fold Change: 3.24
    Ensembl ID: ENSG00000136267
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 3.23
    Ensembl ID: ENSG00000079102
  • Gene Symbol: APBA2 (ENSG00000034053)
    Fold Change: 3.1
    Ensembl ID: ENSG00000034053
  • Gene Symbol: DAB1 (ENSG00000173406)
    Fold Change: 2.93
    Ensembl ID: ENSG00000173406
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 2.88
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.7
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 2.48
    Ensembl ID: ENSG00000198216
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.47
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 2.31
    Ensembl ID: ENSG00000170558
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 2.3
    Ensembl ID: ENSG00000114423
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.29
    Ensembl ID: ENSG00000151067
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.29
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.23
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.21
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.18
    Ensembl ID: ENSG00000152092
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.12
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 2.07
    Ensembl ID: ENSG00000257923
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: 2.06
    Ensembl ID: ENSG00000197381
  • Gene Symbol: CPE (ENSG00000109472)
    Fold Change: 1.96
    Ensembl ID: ENSG00000109472
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 1.94
    Ensembl ID: ENSG00000018236
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.88
    Ensembl ID: ENSG00000127184
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.86
    Ensembl ID: ENSG00000131143
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 1.85
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 1.83
    Ensembl ID: ENSG00000141837
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.83
    Ensembl ID: ENSG00000075624
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.8
    Ensembl ID: ENSG00000107282
  • Gene Symbol: DCX (ENSG00000077279)
    Fold Change: 1.79
    Ensembl ID: ENSG00000077279
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.75
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CACNA1B (ENSG00000148408)
    Fold Change: 1.74
    Ensembl ID: ENSG00000148408
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.71
    Ensembl ID: ENSG00000145741
  • Gene Symbol: VCAN (ENSG00000038427)
    Fold Change: 1.7
    Ensembl ID: ENSG00000038427
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.68
    Ensembl ID: ENSG00000169100
  • Gene Symbol: MPPED2 (ENSG00000066382)
    Fold Change: 1.64
    Ensembl ID: ENSG00000066382
  • Gene Symbol: CTBP2 (ENSG00000175029)
    Fold Change: 1.63
    Ensembl ID: ENSG00000175029
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.57
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.57
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.56
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.51
    Ensembl ID: ENSG00000112695
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.51
    Ensembl ID: ENSG00000078053
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.5
    Ensembl ID: ENSG00000135940
  • Gene Symbol: DAPK1 (ENSG00000196730)
    Fold Change: 1.48
    Ensembl ID: ENSG00000196730
  • Gene Symbol: CRMP1 (ENSG00000072832)
    Fold Change: 1.47
    Ensembl ID: ENSG00000072832
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.45
    Ensembl ID: ENSG00000111775
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.44
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.43
    Ensembl ID: ENSG00000135404
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.43
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.43
    Ensembl ID: ENSG00000173575
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.42
    Ensembl ID: ENSG00000138760
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.4
    Ensembl ID: ENSG00000138696
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.4
    Ensembl ID: ENSG00000067082
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.38
    Ensembl ID: ENSG00000134982
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.38
    Ensembl ID: ENSG00000176340
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.35
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.35
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CREBBP (ENSG00000005339)
    Fold Change: 1.31
    Ensembl ID: ENSG00000005339
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.3
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.29
    Ensembl ID: ENSG00000005022
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.29
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.26
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.24
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.23
    Ensembl ID: ENSG00000185650
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.23
    Ensembl ID: ENSG00000155368
  • Gene Symbol: DCC (ENSG00000187323)
    Fold Change: 1.23
    Ensembl ID: ENSG00000187323
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.22
    Ensembl ID: ENSG00000108684
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.22
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.21
    Ensembl ID: ENSG00000160213
  • Gene Symbol: CDH18 (ENSG00000145526)
    Fold Change: 1.2
    Ensembl ID: ENSG00000145526
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.2
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.2
    Ensembl ID: ENSG00000179218
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.2
    Ensembl ID: ENSG00000148090
  • Gene Symbol: KIF1A (ENSG00000130294)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130294
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.18
    Ensembl ID: ENSG00000156273
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.17
    Ensembl ID: ENSG00000129562
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.17
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.17
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.14
    Ensembl ID: ENSG00000168036
  • Gene Symbol: BRINP1 (ENSG00000078725)
    Fold Change: 1.13
    Ensembl ID: ENSG00000078725
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.12
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198668
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.1
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.07
    Ensembl ID: ENSG00000107779
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.06
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.06
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CACNB4 (ENSG00000182389)
    Fold Change: 1.05
    Ensembl ID: ENSG00000182389
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.05
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.04
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.03
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CHRM3 (ENSG00000133019)
    Fold Change: 1.02
    Ensembl ID: ENSG00000133019
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.01
    Ensembl ID: ENSG00000101439
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Gene Expression**: The interneuron's gene expression profile involves genes involved in calcium ion transport, cell adhesion, and synaptic transmission, including CACNA2D1, ANK3, CTNND2, DACH1, CTNNA2, RERE, and DST. 2. **Morphology**: The interneuron has a characteristic "starburst" pattern of dendritic branching, which allows it to receive synaptic inputs from multiple sources. 3. **Function**: The interneuron plays a crucial role in regulating various physiological and pathological processes, including synaptic transmission, neural activity, and behavior. 4. **Cell Adhesion**: The interneuron is characterized by its ability to form strong cell adhesions with other cells, including astrocytes and oligodendrocytes. 5. **Calcium Ion Transport**: The interneuron's gene expression profile involves genes involved in calcium ion transport, including CACNA2D1 and ANK3. **Clinical Significance** 1. **Neurological Disorders**: The interneuron's dysfunction has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and autism spectrum disorder. 2. **Synaptic Plasticity**: The interneuron's ability to modulate synaptic transmission and plasticity has implications for our understanding of neural development and behavior. 3. **Neural Circuitry**: The interneuron's morphology and function have implications for our understanding of neural circuitry and the integration of neural activity. 4. **Therapeutic Targets**: The interneuron's gene expression profile and function provide potential therapeutic targets for the treatment of neurological disorders. **Pathways/Ontology** The interneuron's gene expression profile and function are regulated by a complex network of transcription factors, including: 1. **Calcium Ion Transport**: CACNA2D1 and ANK3 2. **Cell Adhesion**: CTNND2, DACH1, CTNNA2, and RERE 3. **Synaptic Transmission**: DST and other genes involved in synaptic transmission and plasticity 4. **Neural Activity**: DST and other genes involved in neural activity and behavior Overall, the CNS interneuron is a complex and highly regulated cell type that plays a critical role in regulating various physiological and pathological processes. Further research is needed to fully understand the interneuron's function and to identify potential therapeutic targets for the treatment of neurological disorders.