Cell ID: CL0000453

Cell Name: Langerhans cell

CSI Thresholds:

Select	Context	Threshold
	Overall	9.5337
	Skin epidermis	66.0067
	Skin epidermis + Healthy	65.9302
	Dermis	30.7702
	Dermis + Healthy	30.3924
	Periodontitis	20.2391
	Gingiva + Periodontitis	20.0580
	Nasal cavity + COVID-19	15.7492
	Nasal cavity + Healthy	12.5121
	Bronchus + COVID-19	11.7823
	Gingiva + Healthy	11.4271
	Gingiva	10.8480
	Spleen + Healthy	9.7830
	Spleen	9.7433
	Nasal cavity	9.3211
	Healthy	7.5040
	Gingiva + Gingivitis	6.7558
	Gingivitis	6.7321
	Trachea + COVID-19	4.5997
	COVID-19	3.8374
	Bronchus	3.6740
	Bronchus + Healthy	3.4895
	Skin of body + Healthy	3.1387
	Skin of body	3.0734
	Skin of abdomen + Healthy	2.3959
	Skin of abdomen	2.2344
	Trachea	2.1504
	Liver + Healthy	2.1143
	Trachea + Healthy	1.7938
	Skin of chest + Healthy	0.2807
	Skin of chest	0.0847
	Yolk sac + Healthy	-0.5019
	Yolk sac	-0.5029
	Thymus	-0.8955
	Thymus + Healthy	-0.9040
	Liver	-1.8637

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.

Synonyms: LC