Details for: CL0000453

Cell ID: CL0000453

Cell Name: Langerhans cell

Marker Score Threshold: 299
(Derived using integrated single-cell and genomic data)

Description: Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.

Synonyms: LC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.84
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.49
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.4
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.38
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.33
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.31
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.3
    Ensembl ID: ENSG00000133639
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.23
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.18
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.05
    Ensembl ID: ENSG00000070831
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.02
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.02
    Ensembl ID: ENSG00000143933
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.95
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.94
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.93
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.91
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.84
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.79
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.78
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.78
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.69
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.66
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.66
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.65
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.65
    Ensembl ID: ENSG00000153113
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.61
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.59
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.59
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.58
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.56
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.55
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.54
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.53
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.51
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.48
    Ensembl ID: ENSG00000099624
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.47
    Ensembl ID: ENSG00000104964
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.44
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.44
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.42
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.41
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.4
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.4
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.4
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.39
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.38
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.36
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.35
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.34
    Ensembl ID: ENSG00000160014
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.32
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.32
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.31
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.31
    Ensembl ID: ENSG00000123505
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.3
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110651
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.26
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.25
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.25
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.25
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.24
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.22
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.2
    Ensembl ID: ENSG00000026508
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.19
    Ensembl ID: ENSG00000177879
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.19
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.18
    Ensembl ID: ENSG00000042753
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.17
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.16
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.15
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138279
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.14
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.13
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.12
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.12
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.11
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.11
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.1
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142192
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.09
    Ensembl ID: ENSG00000122218
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.09
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.08
    Ensembl ID: ENSG00000165527
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.05
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.05
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.05
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.05
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.04
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.04
    Ensembl ID: ENSG00000111642
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.04
    Ensembl ID: ENSG00000141367
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.01
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CNN2 (ENSG00000064666)
    Fold Change: 1.01
    Ensembl ID: ENSG00000064666
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.01
    Ensembl ID: ENSG00000006125
  • Gene Symbol: COPB1 (ENSG00000129083)
    Fold Change: N/A
    Ensembl ID: ENSG00000129083
Hovered Details

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Hovered Details

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**Key Characteristics** * Morphology: LCs are stellate dendritic cells with a clear cytoplasm and a dark-staining, indented nucleus. * Location: LCs are found in the epidermis and other stratified epithelia, including the lung, lymph nodes, spleen, and thymus. * Function: LCs play a crucial role in the initiation of immune responses against pathogens and in the regulation of immune homeostasis. * Antigen presentation: LCs can present antigens to T cells via MHC class II molecules. * Activation of immune responses: LCs can activate immune responses by interacting with T cells and other immune cells. * Regulation of immune homeostasis: LCs can regulate immune homeostasis by controlling the activity of immune cells and the production of cytokines. **Clinical Significance** * LCs play a crucial role in the development of autoimmune diseases, such as psoriasis and vitiligo, due to their dysregulation of immune responses. * LCs are involved in the pathogenesis of various cancers, including melanoma and lung cancer, due to their ability to present tumor antigens to T cells. * LCs are also involved in the pathogenesis of infectious diseases, such as HIV and tuberculosis, due to their ability to present antigens to T cells. * LCs have been used as a model system to study the mechanisms of immune responses and to develop new therapies for autoimmune and infectious diseases. * LCs have also been used as a tool to study the development and maintenance of immune homeostasis. **Pathways/Ontology** LCs are involved in various cellular processes, including: * Actin cytoskeleton organization * Adherens junction assembly and disassembly * Apical protein localization * B-wich complex positively regulates rrna expression * Bbaf complex * Blood microparticle formation * Brahma complex * Brush border formation * Calyx of Held formation * Cell-cell communication * Cell-cell junction organization * Cell-extracellular matrix interactions * Cell junction organization * Cell motility * Cellular response to cytochalasin B * Chaperonin-mediated protein folding * Chromatin organization and modification * Clathrin-mediated endocytosis * Cooperation of prefoldin and tric/cct in actin and tubulin folding * Cortical cytoskeleton organization * Cytoplasmic ribonucleoprotein granule formation * Cytoskeleton organization * Cytosol formation * Dense body formation * Deubiquitination * Developmental biology * Disease * Diseases of signal transduction by growth factor receptors and second messengers * Dna damage recognition in gg-ner * Dna repair * Eph-ephrin mediated repulsion of cells * Eph-ephrin signaling * Ephb-mediated forward signaling * Epigenetic regulation of gene expression * Establishment or maintenance of cell polarity * Extracellular exosome formation * Extracellular space formation * Fcgamma receptor (fcgr) dependent phagocytosis * Fcgr3a-mediated phagocytosis * Focal adhesion formation * Folding of actin by cct/tric * Formation of annular gap junctions * Gap junction degradation * Gap junction trafficking and regulation * Gbaf complex * Gene expression (transcription) * Global genome nucleotide excision repair (gg-ner) * Glutamatergic synapse formation * Hats acetylate histones * Hemostasis * Hydrolase activity * Identical protein binding * Immune system * Infectious disease * Innate immune system * Interaction between l1 and ankyrins * Kinesin binding * Kinetochore formation * L1cam interactions * Lamellipodium formation * Leishmania infection * Leishmania phagocytosis * Maintenance of blood-brain barrier * Map2k and mapk activation * Mapk1/mapk3 signaling * Mapk family signaling cascades * Membrane formation * Membrane trafficking * Metabolism of proteins * Morphogenesis of a polarized epithelium * Nbaf complex * Negative regulation of cell differentiation * Negative regulation of protein binding * Nervous system development * Nitric-oxide synthase binding * Npbaf complex * Nua4 histone acetyltransferase complex * Nuclear matrix formation * Nucleoplasm formation * Nucleosomal dna binding * Nucleosome formation * Nucleotide excision repair * Nucleus formation * Oncogenic mapk signaling * Paradoxical activation of raf signaling by kinase inactive braf * Parasite infection pathways * Plasma membrane formation * Platelet aggregation * Positive epigenetic regulation of rrna expression * Positive regulation of cell differentiation * Positive regulation of cell population proliferation * Positive regulation of dna-templated transcription * Positive regulation of double-strand break repair * Positive regulation of double-strand break repair via homologous recombination * Positive regulation of myoblast differentiation * Positive regulation of norepinephrine uptake * Positive regulation of stem cell population maintenance * Positive regulation of t cell differentiation * Post-translational protein modification * Postsynaptic actin cytoskeleton organization * Presynapse formation * Protein-containing complex formation * Protein binding * Protein folding * Protein kinase binding * Protein localization to adherens junction * Raf/map kinase cascade * Recycling pathway of l1 * Regulation of actin dynamics for phagocytic cup formation * Regulation of apoptotic process * Regulation of cell cycle * Regulation of cyclin-dependent protein serine/threonine kinase activity * Regulation of double-strand break repair * Regulation of g0 to g1 transition * Regulation of g1/s transition of mitotic cell cycle * Regulation of mitotic metaphase/anaphase transition * Regulation of norepinephrine uptake * Regulation of nucleotide-excision repair * Regulation of protein localization to plasma membrane * Regulation of synaptic vesicle endocytosis * Regulation of transcription by rna polymerase ii * Regulation of transepithelial transport * Regulation of transmembrane transporter activity * Rhof gtpase cycle * Rho gtpase cycle * Rho gtpase effectors * Rho gtpases activate formins * Rho gtpases activate iqgaps * Rho gtpases activate wasps and waves * Ribonucleoprotein complex formation * Rsc-type complex * Schaffer collateral - ca1 synapse formation * Sensory perception * Sensory processing of sound * Sensory processing of sound by inner hair cells of the cochlea * Sensory processing of sound by outer hair cells of the cochlea * Signaling by braf and raf1 fusions * Signaling by high-kinase activity braf mutants * Signaling by moderate kinase activity braf mutants * Signaling by raf1 mutants * Signaling by ras mutants * Signaling by receptor tyrosine kinases * Signaling by rho gtpases * Signaling by rho gtpases, miro gtpases and rhobtb3 * Signaling by vegf * Signaling downstream of ras mutants * Signal transduction * Structural constituent of cytoskeleton * Structural constituent of postsynaptic actin cytoskeleton * Substantia nigra development * Swi/snf complex * Synapse formation * Tat protein binding * Tau protein binding * Tight junction formation * Translocation of slc2a4 (glut4) to the plasma membrane * Uch proteinases * Vegfa-vegfr2 pathway * Vesicle formation * Vesicle-mediated transport Note: The pathways and ontology listed above are not exhaustive and are based on the available data in the provided text.