Details for: CL0000485

Cell ID: CL0000485

Cell Name: mucosal type mast cell

Marker Score Threshold: 306
(Derived using integrated single-cell and genomic data)

Description: Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype.

Synonyms: MC(T), MCT, T mast cells

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.12
    Ensembl ID: ENSG00000075624
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.93
    Ensembl ID: ENSG00000156508
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.79
    Ensembl ID: ENSG00000127184
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.63
    Ensembl ID: ENSG00000108654
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.53
    Ensembl ID: ENSG00000131143
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.5
    Ensembl ID: ENSG00000167658
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.5
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.24
    Ensembl ID: ENSG00000145741
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.21
    Ensembl ID: ENSG00000164919
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 2.16
    Ensembl ID: ENSG00000156976
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.09
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.08
    Ensembl ID: ENSG00000110955
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.01
    Ensembl ID: ENSG00000114942
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.99
    Ensembl ID: ENSG00000112695
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.98
    Ensembl ID: ENSG00000155368
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.94
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.88
    Ensembl ID: ENSG00000070831
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.86
    Ensembl ID: ENSG00000110321
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.83
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.82
    Ensembl ID: ENSG00000077549
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.79
    Ensembl ID: ENSG00000067082
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.75
    Ensembl ID: ENSG00000169020
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.74
    Ensembl ID: ENSG00000063046
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.73
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.71
    Ensembl ID: ENSG00000154723
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.68
    Ensembl ID: ENSG00000161203
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.67
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.64
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.63
    Ensembl ID: ENSG00000185650
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.63
    Ensembl ID: ENSG00000131174
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.58
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.55
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.55
    Ensembl ID: ENSG00000085224
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.55
    Ensembl ID: ENSG00000215301
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.55
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.53
    Ensembl ID: ENSG00000160213
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.53
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.52
    Ensembl ID: ENSG00000168036
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.49
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.46
    Ensembl ID: ENSG00000113712
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.45
    Ensembl ID: ENSG00000213719
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.41
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.4
    Ensembl ID: ENSG00000116489
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.38
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.37
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.36
    Ensembl ID: ENSG00000196776
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1.36
    Ensembl ID: ENSG00000110367
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.34
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.34
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.34
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.34
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.32
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.32
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.32
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143727
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.3
    Ensembl ID: ENSG00000128951
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.29
    Ensembl ID: ENSG00000197102
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.26
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.25
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 1.23
    Ensembl ID: ENSG00000164733
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.22
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CD55 (ENSG00000196352)
    Fold Change: 1.22
    Ensembl ID: ENSG00000196352
  • Gene Symbol: EIF4E (ENSG00000151247)
    Fold Change: 1.22
    Ensembl ID: ENSG00000151247
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.22
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.21
    Ensembl ID: ENSG00000042753
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.21
    Ensembl ID: ENSG00000177879
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.2
    Ensembl ID: ENSG00000122218
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.19
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.19
    Ensembl ID: ENSG00000148700
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.18
    Ensembl ID: ENSG00000108561
  • Gene Symbol: DGUOK (ENSG00000114956)
    Fold Change: 1.18
    Ensembl ID: ENSG00000114956
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.17
    Ensembl ID: ENSG00000107262
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.16
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.16
    Ensembl ID: ENSG00000134480
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.16
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CYB5R3 (ENSG00000100243)
    Fold Change: 1.15
    Ensembl ID: ENSG00000100243
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.14
    Ensembl ID: ENSG00000153922
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.14
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.13
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.12
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.1
    Ensembl ID: ENSG00000006125
  • Gene Symbol: DYNC1I2 (ENSG00000077380)
    Fold Change: 1.1
    Ensembl ID: ENSG00000077380
  • Gene Symbol: DECR1 (ENSG00000104325)
    Fold Change: 1.07
    Ensembl ID: ENSG00000104325
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 1.07
    Ensembl ID: ENSG00000257923
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.07
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.07
    Ensembl ID: ENSG00000141367
  • Gene Symbol: DARS1 (ENSG00000115866)
    Fold Change: 1.06
    Ensembl ID: ENSG00000115866
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.05
    Ensembl ID: ENSG00000112576
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 1.04
    Ensembl ID: ENSG00000044115
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.04
    Ensembl ID: ENSG00000175416
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.03
    Ensembl ID: ENSG00000183255
  • Gene Symbol: DHX15 (ENSG00000109606)
    Fold Change: 1.03
    Ensembl ID: ENSG00000109606
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.02
    Ensembl ID: ENSG00000137845
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **Serine protease trypase**: The primary granule component of MC(T) cells, responsible for degrading proteins and initiating immune responses. 2. **Mucosal localization**: MC(T) cells are primarily found in mucosal tissue, such as the intestinal mucosa and alveoli, where they play a key role in immune responses. 3. **T-cell dependence**: The development of MC(T) cells depends on T-cells, which suggests a complex interplay between mast cells and other immune cells. 4. **Limited granule content**: MC(T) cells contain only trypase in their granules, which is distinct from other mast cell subtypes that contain a variety of granule components. 5. **Unique signaling pathways**: MC(T) cells have distinct signaling pathways that are involved in immune responses, including the activation of T-cells and the production of cytokines. **Clinical Significance** 1. **Allergic reactions**: MC(T) cells play a key role in allergic reactions, particularly in the context of respiratory allergies and asthma. 2. **Inflammatory processes**: MC(T) cells are involved in inflammatory processes, including the production of cytokines and the activation of immune cells. 3. **Mucosal immunity**: MC(T) cells are essential for mucosal immunity, particularly in the context of respiratory and gastrointestinal diseases. 4. **Immunotherapy**: MC(T) cells have been identified as a potential target for immunotherapy, particularly in the context of allergy and asthma treatment. 5. **Disease association**: MC(T) cells have been associated with various diseases, including asthma, allergies, and inflammatory bowel disease. **Pathways/Ontology** MC(T) cells are involved in a variety of signaling pathways, including: 1. **Actin cytoskeleton**: MC(T) cells regulate actin dynamics to facilitate immune responses. 2. **Adherens junction**: MC(T) cells interact with adherens junctions to regulate cell-cell interactions and immune responses. 3. **Apical junction complex**: MC(T) cells regulate apical junction complex formation to control cell-cell interactions. 4. **Autophagy**: MC(T) cells regulate autophagy to control cellular homeostasis and immune responses. 5. **Cell-cell communication**: MC(T) cells regulate cell-cell communication to facilitate immune responses. Overall, the mucosal type mast cell is a complex and multifunctional cell type that plays a critical role in immune responses, particularly in the context of allergic reactions and inflammatory processes.