Details for: CL0000501

Cell ID: CL0000501

Cell Name: granulosa cell

Marker Score Threshold: 10063
(Derived using integrated single-cell and genomic data)

Description: A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors.

Synonyms: granulosa cell of ovary

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.87
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.86
    Ensembl ID: ENSG00000166710
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 2.85
    Ensembl ID: ENSG00000135409
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.85
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.84
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.79
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.72
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.72
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.68
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.62
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.61
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.59
    Ensembl ID: ENSG00000004059
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.58
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.57
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.53
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.52
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.51
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.49
    Ensembl ID: ENSG00000172270
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.47
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.43
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.37
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.34
    Ensembl ID: ENSG00000185883
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.32
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.28
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.22
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.21
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.21
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.21
    Ensembl ID: ENSG00000169020
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 2.18
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.1
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.08
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 2.07
    Ensembl ID: ENSG00000085662
  • Gene Symbol: FOXL2 (ENSG00000183770)
    Fold Change: 2.03
    Ensembl ID: ENSG00000183770
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 2.01
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 2
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.97
    Ensembl ID: ENSG00000070961
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.96
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.95
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.91
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.82
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.81
    Ensembl ID: ENSG00000105552
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.81
    Ensembl ID: ENSG00000084234
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.79
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.77
    Ensembl ID: ENSG00000177556
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.75
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ARL4D (ENSG00000175906)
    Fold Change: 1.73
    Ensembl ID: ENSG00000175906
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.73
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.72
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.7
    Ensembl ID: ENSG00000087274
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.69
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.67
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.63
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.61
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.57
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.55
    Ensembl ID: ENSG00000148700
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.52
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.52
    Ensembl ID: ENSG00000004455
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.51
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.49
    Ensembl ID: ENSG00000130707
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.48
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.47
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.47
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.46
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.43
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.42
    Ensembl ID: ENSG00000071553
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.39
    Ensembl ID: ENSG00000106605
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160710
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.37
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.36
    Ensembl ID: ENSG00000141522
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100300
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198356
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.34
    Ensembl ID: ENSG00000002330
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.32
    Ensembl ID: ENSG00000149131
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.28
    Ensembl ID: ENSG00000060982
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104763
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.26
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.21
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.16
    Ensembl ID: ENSG00000213465
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.16
    Ensembl ID: ENSG00000151746
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.15
    Ensembl ID: ENSG00000196961
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.13
    Ensembl ID: ENSG00000087088
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.13
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.11
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.09
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.08
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.07
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.07
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.07
    Ensembl ID: ENSG00000120805
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.05
    Ensembl ID: ENSG00000171791
  • Gene Symbol: AK4 (ENSG00000162433)
    Fold Change: 1.04
    Ensembl ID: ENSG00000162433
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.04
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.04
    Ensembl ID: ENSG00000060971
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.03
    Ensembl ID: ENSG00000006125
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.03
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.02
    Ensembl ID: ENSG00000164904
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.01
    Ensembl ID: ENSG00000131100
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Origin**: Granulosa cells develop from the coelomic epithelial cells of the gonadal ridge. 2. **Location**: Granulosa cells are found in the ovaries of mammals, specifically in the primordial ovarian follicle and Graafian follicle. 3. **Structure**: Granulosa cells form a single layer around the oocyte in the primordial ovarian follicle and eventually develop into a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. 4. **Function**: Granulosa cells produce steroids, such as estrogen and progesterone, and LH receptors, which are essential for ovulation, fertilization, and embryogenesis. 5. **Gene Expression**: Granulosa cells express a range of genes involved in cell growth, differentiation, and survival, including genes involved in the regulation of the cell cycle, apoptosis, and DNA repair. **Clinical Significance** 1. **Ovarian Function**: Granulosa cells play a crucial role in the development and maturation of the female gamete, and any dysfunction in these cells can lead to ovulatory disorders, such as anovulatory infertility. 2. **Steroid Production**: Granulosa cells produce essential steroids, such as estrogen and progesterone, which are necessary for the development and maintenance of female reproductive tissues. 3. **LH Receptor Expression**: Granulosa cells express LH receptors, which are essential for ovulation and fertilization. 4. **Cancer**: Granulosa cell tumors are a type of ovarian cancer that arises from the granulosa cells in the ovaries. 5. **Reproductive Health**: Understanding the function and regulation of granulosa cells is essential for the development of effective treatments for reproductive health disorders, such as anovulatory infertility and ovarian cancer. In conclusion, granulosa cells are a critical component of the female reproductive system, and their dysfunction can lead to a range of reproductive health disorders. Further research into the function and regulation of granulosa cells is essential for the development of effective treatments for these disorders.