Cell ID: CL0000510

Cell Name: paneth cell

CSI Thresholds:

Select	Context	Threshold
	Overall	10.3451
	Intestinal mucosa	118.4122
	Intestinal mucosa + Healthy	118.2117
	Colon + Healthy	40.0998
	Sigmoid colon	37.9592
	Sigmoid colon + Crohn disease	37.9366
	Right colon	33.5490
	Right colon + Crohn disease	33.2069
	Colon + Crohn disease	33.1985
	Colon	31.2777
	Intestine	30.6721
	Lamina propria of mucosa of colon	29.9856
	Lamina propria of mucosa of colon + Crohn disease	29.6864
	Colonic epithelium + Crohn disease	26.1995
	Colonic epithelium	26.1594
	Caecum epithelium + Crohn disease	25.7240
	Caecum epithelium	25.4612
	Ileal epithelium + Healthy	22.5911
	Lamina propria of small intestine + Digestive system disorder	22.0118
	Digestive system disorder	21.9350
	Small intestine + Crohn disease	20.9465
	Lamina propria of small intestine	20.3138
	Ileal epithelium + Crohn disease	18.8738
	Ileum	17.9766
	Ileal epithelium	16.7893
	Crohn disease	16.1836
	Epithelium of small intestine + Crohn disease	12.2045
	Small intestine	12.1055
	Epithelium of small intestine	12.0369
	Healthy	10.4195
	Left colon	8.9833
	Left colon + Crohn disease	8.5335
	Ileum + Crohn disease	7.8662
	Intestine + Healthy	6.1099
	Lamina propria of small intestine + Crohn disease	5.2904
	Small intestine + Healthy	5.0604
	Ileum + Healthy	-53.1498

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(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix.