Details for: CL0000510

Cell ID: CL0000510

Cell Name: paneth cell

Marker Score Threshold: 696
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.99
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.51
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.09
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.96
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.84
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.8
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.77
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.62
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.53
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.42
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.42
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.4
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.4
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.35
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.19
    Ensembl ID: ENSG00000099622
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.16
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 2.13
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.08
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.08
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2.05
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.05
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.93
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.9
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.89
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.87
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.84
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.83
    Ensembl ID: ENSG00000070831
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.82
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.79
    Ensembl ID: ENSG00000019582
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.77
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.76
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.73
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.69
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.69
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.64
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.64
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.64
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.63
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.62
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.58
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.57
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.55
    Ensembl ID: ENSG00000143153
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.54
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.53
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 1.51
    Ensembl ID: ENSG00000118971
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.48
    Ensembl ID: ENSG00000162772
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.48
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.47
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.46
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.45
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130402
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.4
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.4
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 1.4
    Ensembl ID: ENSG00000120885
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.37
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.36
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.36
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.35
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.35
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.34
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.34
    Ensembl ID: ENSG00000141367
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.33
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.31
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.3
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.3
    Ensembl ID: ENSG00000085224
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.28
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CDKN1C (ENSG00000129757)
    Fold Change: 1.27
    Ensembl ID: ENSG00000129757
  • Gene Symbol: COPA (ENSG00000122218)
    Fold Change: 1.24
    Ensembl ID: ENSG00000122218
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.22
    Ensembl ID: ENSG00000013441
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.22
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.21
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.21
    Ensembl ID: ENSG00000072110
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.21
    Ensembl ID: ENSG00000090013
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.21
    Ensembl ID: ENSG00000177697
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.2
    Ensembl ID: ENSG00000149823
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.18
    Ensembl ID: ENSG00000108561
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.17
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.15
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.14
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.14
    Ensembl ID: ENSG00000165092
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.14
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.13
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.11
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.1
    Ensembl ID: ENSG00000120805
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198898
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.09
    Ensembl ID: ENSG00000122545
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.09
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.09
    Ensembl ID: ENSG00000196975
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.08
    Ensembl ID: ENSG00000172216
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100852
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.06
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.05
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CDX2 (ENSG00000165556)
    Fold Change: 1.04
    Ensembl ID: ENSG00000165556
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.03
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.01
    Ensembl ID: ENSG00000111642
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1
    Ensembl ID: ENSG00000105810
Hovered Details

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Hovered Details

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**Key Characteristics** * **Location**: Paneth cells are found in the basal part of the intestinal glands (crypts of Lieberkuhn) and the appendix. * **Granules**: Large acidophilic granules containing lysozyme and cryptdins, which are antimicrobial peptides. * **Apical microvilli**: Irregular apical microvilli, which are involved in the absorption of nutrients and the secretion of antimicrobial peptides. * **Membrane-bound vacuoles**: Prominent membrane-bound vacuoles containing matrix, which are involved in the storage and secretion of antimicrobial peptides. * **Zinc content**: Rich in zinc, which is essential for the synthesis and secretion of lysozyme and cryptdins. * **Surface molecules**: Express a range of surface molecules and receptors that facilitate interactions with the immune system, including MHC class I and II molecules. **Clinical Significance** Paneth cells play a crucial role in maintaining the intestinal homeostasis and defense against pathogens. Dysregulation of Paneth cell function has been implicated in various gastrointestinal disorders, including: * **Irritable bowel syndrome (IBS)**: Abnormal Paneth cell function has been linked to the development of IBS. * **Inflammatory bowel disease (IBD)**: Paneth cell dysfunction has been implicated in the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. * **Cancer**: Paneth cell dysregulation has been associated with various types of cancer, including colorectal cancer. * **Immunodeficiency disorders**: Paneth cell dysfunction has been linked to immunodeficiency disorders, such as celiac disease and autoimmune disorders. In addition, Paneth cells are involved in various immune responses, including: * **Antigen processing and presentation**: Paneth cells process and present antigens to T cells, which is essential for the activation of immune responses. * **Cytokine production**: Paneth cells produce cytokines, which are essential for the regulation of immune responses. * **Immune cell activation**: Paneth cells activate immune cells, including T cells and natural killer cells, which is essential for the defense against pathogens. Overall, Paneth cells play a crucial role in maintaining the intestinal homeostasis and defense against pathogens, and dysregulation of Paneth cell function has been implicated in various gastrointestinal disorders.