CL0000525 - syncytiotrophoblast cell details

Details for: CL0000525

Cell ID: CL0000525

Cell Name: syncytiotrophoblast cell

Marker Score Threshold: 821
(Derived using integrated single-cell and genomic data)

Description: A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.

Synonyms: syncytial trophoblast cell, syncytiotrophoblastic cell, plasmidotrophoblast cell, syntrophoblast cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: RERE (ENSG00000142599)
Fold Change: 5.32
Ensembl ID: ENSG00000142599
Gene Symbol: APP (ENSG00000142192)
Fold Change: 4.89
Ensembl ID: ENSG00000142192
Gene Symbol: CDKN1C (ENSG00000129757)
Fold Change: 4.68
Ensembl ID: ENSG00000129757
Gene Symbol: ADK (ENSG00000156110)
Fold Change: 4.5
Ensembl ID: ENSG00000156110
Gene Symbol: APBB2 (ENSG00000163697)
Fold Change: 3.79
Ensembl ID: ENSG00000163697
Gene Symbol: LRBA (ENSG00000198589)
Fold Change: 3.71
Ensembl ID: ENSG00000198589
Gene Symbol: ANK3 (ENSG00000151150)
Fold Change: 3.55
Ensembl ID: ENSG00000151150
Gene Symbol: BCL2 (ENSG00000171791)
Fold Change: 3.54
Ensembl ID: ENSG00000171791
Gene Symbol: BRAF (ENSG00000157764)
Fold Change: 3.16
Ensembl ID: ENSG00000157764
Gene Symbol: ZFHX3 (ENSG00000140836)
Fold Change: 3.07
Ensembl ID: ENSG00000140836
Gene Symbol: CDK6 (ENSG00000105810)
Fold Change: 2.71
Ensembl ID: ENSG00000105810
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 2.67
Ensembl ID: ENSG00000084234
Gene Symbol: CAMK2G (ENSG00000148660)
Fold Change: 2.66
Ensembl ID: ENSG00000148660
Gene Symbol: ALDH7A1 (ENSG00000164904)
Fold Change: 2.5
Ensembl ID: ENSG00000164904
Gene Symbol: CDH1 (ENSG00000039068)
Fold Change: 2.39
Ensembl ID: ENSG00000039068
Gene Symbol: STS (ENSG00000101846)
Fold Change: 2.37
Ensembl ID: ENSG00000101846
Gene Symbol: ATP2B1 (ENSG00000070961)
Fold Change: 2.35
Ensembl ID: ENSG00000070961
Gene Symbol: ANXA1 (ENSG00000135046)
Fold Change: 2.33
Ensembl ID: ENSG00000135046
Gene Symbol: COL4A2 (ENSG00000134871)
Fold Change: 2.32
Ensembl ID: ENSG00000134871
Gene Symbol: ACKR2 (ENSG00000144648)
Fold Change: 2.31
Ensembl ID: ENSG00000144648
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 2.08
Ensembl ID: ENSG00000072778
Gene Symbol: BMPR2 (ENSG00000204217)
Fold Change: 2.05
Ensembl ID: ENSG00000204217
Gene Symbol: CALD1 (ENSG00000122786)
Fold Change: 2.03
Ensembl ID: ENSG00000122786
Gene Symbol: FOXN3 (ENSG00000053254)
Fold Change: 2.02
Ensembl ID: ENSG00000053254
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.99
Ensembl ID: ENSG00000130402
Gene Symbol: CAST (ENSG00000153113)
Fold Change: 1.84
Ensembl ID: ENSG00000153113
Gene Symbol: ALB (ENSG00000163631)
Fold Change: 1.82
Ensembl ID: ENSG00000163631
Gene Symbol: CHD2 (ENSG00000173575)
Fold Change: 1.77
Ensembl ID: ENSG00000173575
Gene Symbol: BSG (ENSG00000172270)
Fold Change: 1.77
Ensembl ID: ENSG00000172270
Gene Symbol: ZFP36L1 (ENSG00000185650)
Fold Change: 1.71
Ensembl ID: ENSG00000185650
Gene Symbol: MAPK14 (ENSG00000112062)
Fold Change: 1.7
Ensembl ID: ENSG00000112062
Gene Symbol: ABL1 (ENSG00000097007)
Fold Change: 1.62
Ensembl ID: ENSG00000097007
Gene Symbol: CSF2RA (ENSG00000198223)
Fold Change: 1.57
Ensembl ID: ENSG00000198223
Gene Symbol: COL3A1 (ENSG00000168542)
Fold Change: 1.56
Ensembl ID: ENSG00000168542
Gene Symbol: CALR (ENSG00000179218)
Fold Change: 1.55
Ensembl ID: ENSG00000179218
Gene Symbol: ANXA5 (ENSG00000164111)
Fold Change: 1.53
Ensembl ID: ENSG00000164111
Gene Symbol: ADCY2 (ENSG00000078295)
Fold Change: 1.52
Ensembl ID: ENSG00000078295
Gene Symbol: CLTC (ENSG00000141367)
Fold Change: 1.51
Ensembl ID: ENSG00000141367
Gene Symbol: BMPR1A (ENSG00000107779)
Fold Change: 1.48
Ensembl ID: ENSG00000107779
Gene Symbol: CGA (ENSG00000135346)
Fold Change: 1.45
Ensembl ID: ENSG00000135346
Gene Symbol: DST (ENSG00000151914)
Fold Change: 1.44
Ensembl ID: ENSG00000151914
Gene Symbol: ASPH (ENSG00000198363)
Fold Change: 1.44
Ensembl ID: ENSG00000198363
Gene Symbol: CREBBP (ENSG00000005339)
Fold Change: 1.43
Ensembl ID: ENSG00000005339
Gene Symbol: AGL (ENSG00000162688)
Fold Change: 1.42
Ensembl ID: ENSG00000162688
Gene Symbol: CLDN4 (ENSG00000189143)
Fold Change: 1.41
Ensembl ID: ENSG00000189143
Gene Symbol: BMP7 (ENSG00000101144)
Fold Change: 1.4
Ensembl ID: ENSG00000101144
Gene Symbol: CLIC1 (ENSG00000213719)
Fold Change: 1.38
Ensembl ID: ENSG00000213719
Gene Symbol: ATP5PF (ENSG00000154723)
Fold Change: 1.37
Ensembl ID: ENSG00000154723
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 1.37
Ensembl ID: ENSG00000184009
Gene Symbol: CBLB (ENSG00000114423)
Fold Change: 1.37
Ensembl ID: ENSG00000114423
Gene Symbol: ATP5F1B (ENSG00000110955)
Fold Change: 1.36
Ensembl ID: ENSG00000110955
Gene Symbol: B2M (ENSG00000166710)
Fold Change: 1.36
Ensembl ID: ENSG00000166710
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 1.32
Ensembl ID: ENSG00000135390
Gene Symbol: ATP5F1E (ENSG00000124172)
Fold Change: 1.31
Ensembl ID: ENSG00000124172
Gene Symbol: CAPZB (ENSG00000077549)
Fold Change: 1.3
Ensembl ID: ENSG00000077549
Gene Symbol: ATP2B4 (ENSG00000058668)
Fold Change: 1.29
Ensembl ID: ENSG00000058668
Gene Symbol: CLN3 (ENSG00000188603)
Fold Change: 1.29
Ensembl ID: ENSG00000188603
Gene Symbol: ATP5F1A (ENSG00000152234)
Fold Change: 1.28
Ensembl ID: ENSG00000152234
Gene Symbol: ARHGAP6 (ENSG00000047648)
Fold Change: 1.27
Ensembl ID: ENSG00000047648
Gene Symbol: ATP5MC3 (ENSG00000154518)
Fold Change: 1.27
Ensembl ID: ENSG00000154518
Gene Symbol: COL1A1 (ENSG00000108821)
Fold Change: 1.26
Ensembl ID: ENSG00000108821
Gene Symbol: COX7B (ENSG00000131174)
Fold Change: 1.26
Ensembl ID: ENSG00000131174
Gene Symbol: ATP5PO (ENSG00000241837)
Fold Change: 1.25
Ensembl ID: ENSG00000241837
Gene Symbol: COL4A1 (ENSG00000187498)
Fold Change: 1.25
Ensembl ID: ENSG00000187498
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 1.24
Ensembl ID: ENSG00000165629
Gene Symbol: COX7C (ENSG00000127184)
Fold Change: 1.24
Ensembl ID: ENSG00000127184
Gene Symbol: RHOA (ENSG00000067560)
Fold Change: 1.24
Ensembl ID: ENSG00000067560
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 1.23
Ensembl ID: ENSG00000075624
Gene Symbol: BTF3 (ENSG00000145741)
Fold Change: 1.22
Ensembl ID: ENSG00000145741
Gene Symbol: COX7A2 (ENSG00000112695)
Fold Change: 1.22
Ensembl ID: ENSG00000112695
Gene Symbol: COX4I1 (ENSG00000131143)
Fold Change: 1.21
Ensembl ID: ENSG00000131143
Gene Symbol: COX6A1 (ENSG00000111775)
Fold Change: 1.2
Ensembl ID: ENSG00000111775
Gene Symbol: ARRB1 (ENSG00000137486)
Fold Change: 1.2
Ensembl ID: ENSG00000137486
Gene Symbol: CCND3 (ENSG00000112576)
Fold Change: 1.2
Ensembl ID: ENSG00000112576
Gene Symbol: ATP5PB (ENSG00000116459)
Fold Change: 1.19
Ensembl ID: ENSG00000116459
Gene Symbol: CIRBP (ENSG00000099622)
Fold Change: 1.17
Ensembl ID: ENSG00000099622
Gene Symbol: ANXA2 (ENSG00000182718)
Fold Change: 1.15
Ensembl ID: ENSG00000182718
Gene Symbol: CHD1 (ENSG00000153922)
Fold Change: 1.15
Ensembl ID: ENSG00000153922
Gene Symbol: SLC25A6 (ENSG00000169100)
Fold Change: 1.14
Ensembl ID: ENSG00000169100
Gene Symbol: COX5B (ENSG00000135940)
Fold Change: 1.14
Ensembl ID: ENSG00000135940
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 1.14
Ensembl ID: ENSG00000169020
Gene Symbol: BTG1 (ENSG00000133639)
Fold Change: 1.14
Ensembl ID: ENSG00000133639
Gene Symbol: COX6C (ENSG00000164919)
Fold Change: 1.14
Ensembl ID: ENSG00000164919
Gene Symbol: TMEM258 (ENSG00000134825)
Fold Change: 1.13
Ensembl ID: ENSG00000134825
Gene Symbol: CFL1 (ENSG00000172757)
Fold Change: 1.13
Ensembl ID: ENSG00000172757
Gene Symbol: ADD3 (ENSG00000148700)
Fold Change: 1.12
Ensembl ID: ENSG00000148700
Gene Symbol: COX6B1 (ENSG00000126267)
Fold Change: 1.12
Ensembl ID: ENSG00000126267
Gene Symbol: ATP5F1D (ENSG00000099624)
Fold Change: 1.11
Ensembl ID: ENSG00000099624
Gene Symbol: BCKDHB (ENSG00000083123)
Fold Change: 1.11
Ensembl ID: ENSG00000083123
Gene Symbol: ACYP2 (ENSG00000170634)
Fold Change: 1.1
Ensembl ID: ENSG00000170634
Gene Symbol: ATP6AP1 (ENSG00000071553)
Fold Change: 1.08
Ensembl ID: ENSG00000071553
Gene Symbol: CLTA (ENSG00000122705)
Fold Change: 1.07
Ensembl ID: ENSG00000122705
Gene Symbol: CALM1 (ENSG00000198668)
Fold Change: 1.04
Ensembl ID: ENSG00000198668
Gene Symbol: PTTG1IP (ENSG00000183255)
Fold Change: 1.03
Ensembl ID: ENSG00000183255
Gene Symbol: CANX (ENSG00000127022)
Fold Change: 1.03
Ensembl ID: ENSG00000127022
Gene Symbol: BCAT1 (ENSG00000060982)
Fold Change: 1.03
Ensembl ID: ENSG00000060982
Gene Symbol: SLC25A5 (ENSG00000005022)
Fold Change: 1.03
Ensembl ID: ENSG00000005022
Gene Symbol: ANXA4 (ENSG00000196975)
Fold Change: 1.02
Ensembl ID: ENSG00000196975
Gene Symbol: CD63 (ENSG00000135404)
Fold Change: 1.02
Ensembl ID: ENSG00000135404
Gene Symbol: ATP6V0B (ENSG00000117410)
Fold Change: 1.01
Ensembl ID: ENSG00000117410

Gene representation (1490)
Gene/Pathway representation (1490)

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**Key Characteristics** * **Cell Type**: Syncytiotrophoblast cell * **Location**: Outer syncytial layer of the trophoblast of an early mammalian embryo * **Function**: Maintains maternal blood supply and supports embryonic development * **Secretion**: Human chorionic gonadotropin (hCG) * **Genes**: + Gene Symbol: RERE + Ensembl ID: ENSG00000142599 + Gene Symbol: APP + Ensembl ID: ENSG00000142192 + Gene Symbol: CDKN1C + Ensembl ID: ENSG00000129757 **Clinical Significance** The syncytiotrophoblast cell has been implicated in several diseases, including: * **Cancer**: The cell's genes, including APP and CDKN1C, have been studied in the context of cancer, particularly in the development of neurodegenerative diseases. * **Neurodegenerative Diseases**: The cell's genes have been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. * **Immune System Disorders**: The cell's genes have been implicated in immune system disorders, including autoimmune diseases and inflammatory conditions. * **Placental Disorders**: The cell's genes have been implicated in placental disorders, including preeclampsia and intrauterine growth restriction. The syncytiotrophoblast cell's role in maintaining the maternal blood supply and supporting embryonic development highlights the importance of understanding its function and regulation in the context of pregnancy and fetal development. **Pathways and Ontologies** The syncytiotrophoblast cell's genes have been implicated in various signaling pathways, including: * **Branching Morphogenesis of a Nerve** * **Cerebellar Granule Cell Precursor Proliferation** * **Cerebellar Purkinje Cell Layer Maturation** * **Chromatin Binding** * **Chromatin Remodeling** * **Dendrite Morphogenesis** * **Histone Deacetylase Complex** * **Metal Ion Binding** * **Negative Regulation of DNA-templated Transcription** * **Nuclear Body** * **Nucleoplasm** * **Nucleus** * **Positive Regulation of DNA-templated Transcription** * **Protein Binding** * **Radial Glia Guided Migration of Purkinje Cell** * **Sequence-specific DNA Binding** * **Transcription Coactivator Activity** * **Transcription Corepressor Activity** The cell's genes have also been implicated in various ontologies, including: * **Adult Locomotory Behavior** * **Advanced Glycosylation Endproduct Receptor Signaling** * **Amyloid Fiber Formation** * **Amyloid Fibril Formation** * **Apical Part of Cell** * **Astrocyte Activation** * **Astrocyte Activation Involved in Immune Response** * **Axo-dendritic Transport** * **Axon** * **Axon Midline Choice Point Recognition** * **Axonogenesis** * **Cell-cell Junction** * **Cell Adhesion** * **Cell Recruitment (pro-inflammatory response)** * **Cell Surface** * **Cellular Response to Amyloid-beta** * **Central Nervous System Development** * **Cholesterol Metabolic Process** * **Ciliary Rootlet** * **Class a/1 (rhodopsin-like receptors)** * **Clathrin-coated Pit** * **Cognition** * **Collateral Sprouting in Absence of Injury** * **Copii-coated ER to Golgi Transport Vesicle** * **Cytokine Signaling in Immune System** * **Cytoplasm** * **Cytoplasmic Polyadenylation** * **Cytosol** * **Ddx58/ifih1-mediated Induction of Interferon-alpha/beta** * **Defective Intrinsic Pathway for Apoptosis** * **Dendrite Development** * **Dendritic Shaft** * **Dendritic Spine** * **Deregulated Cdk5 Triggers Multiple Neurodegenerative Pathways in Alzheimer's Disease Models** * **Disease** * **Diseases of Programmed Cell Death** * **DNA Binding** * **Early Endosome** * **Ecm Proteoglycans** * **Endocytosis** * **Endoplasmic Reticulum** * **Endoplasmic Reticulum Lumen** * **Endosome** * **Endosome Lumen** * **Enzyme Binding** * **Extracellular Exosome** * **Extracellular Matrix Organization** * **Extracellular Region** * **Extracellular Space** * **Forebrain Development** * **Formyl Peptide Receptors Bind Formyl Peptides and Many Other Ligands** * **G2/m Transition of Mitotic Cell Cycle** * **G alpha (i) Signalling Events** * **G alpha (q) Signalling Events** * **Golgi-associated Vesicle** * **Golgi Apparatus** * **Golgi Lumen** * **Gpcr Downstream Signalling** * **Gpcr Ligand Binding** * **Growth Cone** * **Hemostasis** * **Heparin Binding** * **Identical Protein Binding** * **Immune System** * **Infectious Disease** * **Inflammasomes** * **Innate Immune System** * **Insertion of Tail-anchored Proteins into the Endoplasmic Reticulum Membrane** * **Interleukin-1 Family Signalling** * **Interleukin-1 Signalling** * **Intracellular Copper Ion Homeostasis** * **Ionotropic Glutamate Receptor Signalling Pathway** * **Learning** * **Learning or Memory** * **Leishmania Infection** * **Locomotory Behaviour** * **Lysosome Vesicle Biogenesis** * **Mating Behaviour** * **Membrane** * **Membrane Raft** * **Membrane Trafficking** * **Metabolism of Proteins** * **Microglia Development** * **Microglial Cell Activation** * **Mitochondrial Protein Degradation** * **Modulation of Excitatory Postsynaptic Potential** * **Mrna Polyadenylation** * **Myd88 Cascade Initiated on Plasma Membrane** * **Myd88-dependent Cascade Initiated on Endosome** * **Myd88-independent TLR4 Cascade** * **Myd88:Mal(TIRAP) Cascade Initiated on Plasma Membrane** * **Negative Regulation of Cell Population Proliferation** * **Negative Regulation of Gene Expression** * **Negative Regulation of Long-term Synaptic Potentiation** * **Negative Regulation of Low-density Lipoprotein Receptor Activity** * **Negative Regulation of Neuron Differentiation** * **Neurodegenerative Diseases** * **Neuromuscular Junction** * **Neuromuscular Process Controlling Balance** * **Neuron Apoptotic Process** * **Neuron Cellular Homeostasis** * **Neuron Projection Development** * **Neuron Projection Maintenance** * **Neuron Remodeling** * **Notch Signalling Pathway** * **Nuclear Envelope Lumen** * **Nucleotide-binding Domain, Leucine-rich Repeat Containing Receptor (NLR) Signalling Pathways** * **Parasitic Infection Pathways** * **Peptide Ligand-binding Receptors** * **Perikaryon** * **Perinuclear Region of Cytoplasm** * **Plasma Membrane** * **Platelet Activation, Signalling and Aggregation** * **Platelet alpha Granule Lumen** * **Platelet Degranulation** * **Positive Regulation of Amyloid Fibril Formation** * **Positive Regulation of Calcium-mediated Signalling** * **Positive Regulation of Chemokine Production** * **Positive Regulation of DNA-binding Transcription Factor Activity** * **Positive Regulation of Erk1 and Erk2 Cascade** * **Positive Regulation of G2/m Transition of Mitotic Cell Cycle** * **Positive Regulation of Gene Expression** * **Positive Regulation of Glycolytic Process** * **Positive Regulation of Inflammatory Response** * **Positive Regulation of Interleukin-1 Beta Production** * **Positive Regulation of Interleukin-6 Production** * **Positive Regulation of JNK Cascade** * **Positive Regulation of Long-term Synaptic Potentiation** * **Positive Regulation of Mitotic Cell Cycle** * **Positive Regulation of Non-canonical NF-kB Signalling** * **Positive Regulation of Peptidyl-serine Phosphorylation** * **Positive Regulation of Peptidyl-threonine Phosphorylation** * **Positive Regulation of Protein Binding** * **Positive Regulation of Protein Metabolic Process** * **Positive Regulation of Protein Phosphorylation** * **Positive Regulation of T Cell Migration** * **Positive Regulation of Transcription by RNA Polymer

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.