Details for: CL0000546

Cell ID: CL0000546

Cell Name: T-helper 2 cell

Marker Score Threshold: 411
(Derived using integrated single-cell and genomic data)

Description: A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4.

Synonyms: T helper cells type 2, T(H)-2 cell, Th2 T cell, Th2 T lymphocyte, Th2 T-cell, Th2 T-lymphocyte, Th2 cell, helper T cell type 2

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.74
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.61
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.61
    Ensembl ID: ENSG00000156508
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.3
    Ensembl ID: ENSG00000108654
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.26
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.24
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.22
    Ensembl ID: ENSG00000169100
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.2
    Ensembl ID: ENSG00000167658
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.19
    Ensembl ID: ENSG00000172757
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.18
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.15
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.11
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.03
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.03
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.94
    Ensembl ID: ENSG00000135390
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.92
    Ensembl ID: ENSG00000156976
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.9
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.89
    Ensembl ID: ENSG00000124172
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.87
    Ensembl ID: ENSG00000114942
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.87
    Ensembl ID: ENSG00000133639
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.78
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.75
    Ensembl ID: ENSG00000067560
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.75
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.75
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.75
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.71
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.71
    Ensembl ID: ENSG00000135940
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.62
    Ensembl ID: ENSG00000067082
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.62
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.61
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.61
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.6
    Ensembl ID: ENSG00000169020
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.58
    Ensembl ID: ENSG00000120129
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.57
    Ensembl ID: ENSG00000176340
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.5
    Ensembl ID: ENSG00000154723
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.48
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.48
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.47
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.46
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.45
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.44
    Ensembl ID: ENSG00000213719
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.44
    Ensembl ID: ENSG00000134825
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.43
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.43
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.41
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.41
    Ensembl ID: ENSG00000051523
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.4
    Ensembl ID: ENSG00000155368
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.38
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.36
    Ensembl ID: ENSG00000160213
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.35
    Ensembl ID: ENSG00000215301
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.34
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.34
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.33
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.33
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.32
    Ensembl ID: ENSG00000122705
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.32
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.32
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.31
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.3
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.27
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.27
    Ensembl ID: ENSG00000165629
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.25
    Ensembl ID: ENSG00000157514
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.25
    Ensembl ID: ENSG00000173674
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.24
    Ensembl ID: ENSG00000101439
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.24
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.22
    Ensembl ID: ENSG00000013441
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.22
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.21
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.2
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.19
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.19
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.17
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.16
    Ensembl ID: ENSG00000117984
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.16
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.16
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.16
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.15
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.15
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.14
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.13
    Ensembl ID: ENSG00000168036
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.12
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.1
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.1
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.09
    Ensembl ID: ENSG00000173575
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.07
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.07
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.07
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.06
    Ensembl ID: ENSG00000122359
  • Gene Symbol: EIF2S3 (ENSG00000130741)
    Fold Change: 1.06
    Ensembl ID: ENSG00000130741
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149925
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.05
    Ensembl ID: ENSG00000197102
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.03
    Ensembl ID: ENSG00000159199
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.02
    Ensembl ID: ENSG00000053254
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.02
    Ensembl ID: ENSG00000128951
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072778
  • Gene Symbol: EIF4A1 (ENSG00000161960)
    Fold Change: 1.01
    Ensembl ID: ENSG00000161960
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1
    Ensembl ID: ENSG00000108561
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1
    Ensembl ID: ENSG00000110367
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **CD4-positive, alpha-beta T cells**: Th2 cells are a subset of CD4-positive T cells, which are a type of T lymphocyte that plays a central role in the adaptive immune response. 2. **GATA-3-positive**: Th2 cells express the transcription factor GATA-3, which is necessary for the development and function of Th2 cells. 3. **CXCR3-negative**: Th2 cells do not express the chemokine receptor CXCR3, which is typically expressed by Th1 cells. 4. **CCR6-negative**: Th2 cells do not express the chemokine receptor CCR6, which is typically expressed by Th17 cells and other subsets of T cells. 5. **IL-4 production**: Th2 cells are capable of producing the cytokine IL-4, which is a key regulator of the immune response against parasites and in the pathogenesis of allergic diseases. 6. **Th2 cytokine profile**: Th2 cells produce a distinct cytokine profile, including IL-4, IL-5, and IL-13, which contribute to their effector functions. **Clinical Significance** 1. **Allergic diseases**: Th2 cells play a key role in the pathogenesis of allergic diseases, such as asthma, atopic dermatitis, and allergic rhinitis. 2. **Parasitic infections**: Th2 cells are involved in the regulation of immune responses against parasites, such as hookworms and roundworms. 3. **Autoimmune diseases**: Th2 cells have been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Cancer**: Th2 cells have been shown to contribute to the development and progression of certain types of cancer, such as breast cancer and lung cancer. 5. **Immunotherapy**: Th2 cells are a target for immunotherapy, as they are involved in the regulation of immune responses against tumors and other diseases. In conclusion, the T-helper 2 cell is a critical subset of CD4-positive, alpha-beta T cells that plays a key role in the regulation of immune responses against parasites and in the pathogenesis of allergic diseases. Understanding the characteristics and clinical significance of Th2 cells is essential for the development of effective immunotherapies and treatments for a range of diseases.