Details for: CL0000547

Cell ID: CL0000547

Cell Name: proerythroblast

Marker Score Threshold: 678
(Derived using integrated single-cell and genomic data)

Description: An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.

Synonyms: rubriblast, pronormoblast

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.02
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.99
    Ensembl ID: ENSG00000159199
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.98
    Ensembl ID: ENSG00000130208
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.97
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.97
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.93
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.93
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.91
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.89
    Ensembl ID: ENSG00000198931
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.84
    Ensembl ID: ENSG00000106605
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.83
    Ensembl ID: ENSG00000143933
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.83
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.8
    Ensembl ID: ENSG00000029534
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.79
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.78
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.77
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.76
    Ensembl ID: ENSG00000241837
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.74
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.73
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.71
    Ensembl ID: ENSG00000075239
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.7
    Ensembl ID: ENSG00000004455
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.69
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.69
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.67
    Ensembl ID: ENSG00000116459
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.67
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CA2 (ENSG00000104267)
    Fold Change: 1.65
    Ensembl ID: ENSG00000104267
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.63
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ALAD (ENSG00000148218)
    Fold Change: 1.6
    Ensembl ID: ENSG00000148218
  • Gene Symbol: ADSL (ENSG00000239900)
    Fold Change: 1.59
    Ensembl ID: ENSG00000239900
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.59
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1.59
    Ensembl ID: ENSG00000138363
  • Gene Symbol: ALAS2 (ENSG00000158578)
    Fold Change: 1.57
    Ensembl ID: ENSG00000158578
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.56
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.54
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.53
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.52
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: 1.52
    Ensembl ID: ENSG00000136518
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.5
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.49
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.49
    Ensembl ID: ENSG00000204574
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.47
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.46
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: 1.43
    Ensembl ID: ENSG00000075340
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.43
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.42
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.42
    Ensembl ID: ENSG00000198668
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.42
    Ensembl ID: ENSG00000166710
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.42
    Ensembl ID: ENSG00000006125
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.41
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.35
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.35
    Ensembl ID: ENSG00000100300
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.34
    Ensembl ID: ENSG00000164062
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.31
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.31
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.3
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AP2A1 (ENSG00000196961)
    Fold Change: 1.29
    Ensembl ID: ENSG00000196961
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.29
    Ensembl ID: ENSG00000060982
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.29
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.29
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.28
    Ensembl ID: ENSG00000168374
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.27
    Ensembl ID: ENSG00000067560
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.27
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BLMH (ENSG00000108578)
    Fold Change: 1.26
    Ensembl ID: ENSG00000108578
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.25
    Ensembl ID: ENSG00000015475
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.25
    Ensembl ID: ENSG00000104765
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.24
    Ensembl ID: ENSG00000143799
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.24
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.24
    Ensembl ID: ENSG00000117410
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.24
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 1.22
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: 1.2
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.2
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.19
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.18
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.18
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: 1.18
    Ensembl ID: ENSG00000131473
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.17
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BMI1 (ENSG00000168283)
    Fold Change: 1.16
    Ensembl ID: ENSG00000168283
  • Gene Symbol: BRCA1 (ENSG00000012048)
    Fold Change: 1.15
    Ensembl ID: ENSG00000012048
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.14
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACY1 (ENSG00000243989)
    Fold Change: 1.12
    Ensembl ID: ENSG00000243989
  • Gene Symbol: ATF1 (ENSG00000123268)
    Fold Change: 1.11
    Ensembl ID: ENSG00000123268
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.11
    Ensembl ID: ENSG00000163399
  • Gene Symbol: POLR3D (ENSG00000168495)
    Fold Change: 1.11
    Ensembl ID: ENSG00000168495
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.09
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.09
    Ensembl ID: ENSG00000069849
  • Gene Symbol: BCAT2 (ENSG00000105552)
    Fold Change: 1.08
    Ensembl ID: ENSG00000105552
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.07
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.05
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.04
    Ensembl ID: ENSG00000149311
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.02
    Ensembl ID: ENSG00000142188
  • Gene Symbol: BCS1L (ENSG00000074582)
    Fold Change: 1.02
    Ensembl ID: ENSG00000074582
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.02
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP7A (ENSG00000165240)
    Fold Change: 1.02
    Ensembl ID: ENSG00000165240
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.01
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.01
    Ensembl ID: ENSG00000174437
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** 1. **CD71-positive expression**: The proerythroblast expresses CD71, a marker of erythroid progenitor cells. 2. **Nucleated and nucleolus present**: The proerythroblast has a nucleus and nucleolus, indicating its immaturity. 3. **Lack of hematopoietic lineage markers**: The proerythroblast lacks markers of other hematopoietic lineages, such as CD34 and CD133. 4. **Biliverdin reductase activity**: The proerythroblast is involved in the reduction of biliverdin to bilirubin, a crucial step in heme degradation. 5. **Mitochondrial function**: The proerythroblast has a functional mitochondrion, necessary for ATP synthesis and energy production. **Clinical Significance** 1. **Erythropoiesis disorders**: Dysfunction of the proerythroblast can lead to various erythropoiesis disorders, such as anemia, polycythemia, and leukemias. 2. **Hematological malignancies**: Abnormalities in the proerythroblast can contribute to the development of hematological malignancies, such as acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). 3. **Organ dysfunction**: Severe dysfunction of the proerythroblast can lead to organ dysfunction, particularly in the kidneys and brain. **Pathways Involved** 1. **Biliberdin reductase activity**: The proerythroblast is involved in the reduction of biliverdin to bilirubin, a crucial step in heme degradation. 2. **Mitochondrial biogenesis and function**: The proerythroblast has a functional mitochondrion, necessary for ATP synthesis and energy production. 3. **Apoptosis and cell survival**: The proerythroblast is involved in apoptosis and cell survival pathways, regulating the number of red blood cells produced. 4. **Immune response**: The proerythroblast is involved in the immune response, particularly in the regulation of complement activation and apoptosis. **Genes and Enzymes Involved** 1. **BLVRB gene**: The BLVRB gene encodes the biliverdin reductase enzyme, necessary for heme degradation. 2. **ATP5MC1 gene**: The ATP5MC1 gene encodes the ATP synthase complex, necessary for mitochondrial energy production. 3. **APOC1 gene**: The APOC1 gene encodes the apolipoprotein C1 protein, involved in lipid metabolism and transport. 4. **C1QBP gene**: The C1QBP gene encodes the C1q-binding protein, involved in complement activation and apoptosis. 5. **BSG gene**: The BSG gene encodes the basigin protein, involved in cell surface interactions and adhesion. 6. **ATP5ME and ATP5MC3 genes**: These genes encode the ATP synthase complex, necessary for mitochondrial energy production. **Conclusion** The proerythroblast is a crucial stage in the development of red blood cells, and its dysfunction can lead to various hematological disorders. Understanding the key characteristics, clinical significance, and pathways involved in the function of the proerythroblast is essential for the diagnosis and treatment of hematological disorders.