Details for: CL0000553

Cell ID: CL0000553

Cell Name: megakaryocyte progenitor cell

Marker Score Threshold: 279
(Derived using integrated single-cell and genomic data)

Description: The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).

Synonyms: CFU-Meg, Meg-CFC, MkP, colony-forming unit-megakaryocyte, megacaryoblast, megacaryocyte progenitor cell, megakaryoblast, megakaryocytic progenitor cell, promegacaryocyte, promegakaryocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.58
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.18
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.9
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.78
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.71
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.69
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.58
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.54
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.45
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.39
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.33
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.26
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.16
    Ensembl ID: ENSG00000152518
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.13
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.1
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.08
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.01
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.96
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.91
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.91
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.89
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.86
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.84
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.83
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.8
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.77
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.7
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.7
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.69
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.69
    Ensembl ID: ENSG00000149925
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.67
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.64
    Ensembl ID: ENSG00000182718
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.63
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.59
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.58
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.58
    Ensembl ID: ENSG00000164111
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1.56
    Ensembl ID: ENSG00000105810
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.54
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.49
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.48
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.47
    Ensembl ID: ENSG00000196776
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.47
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.46
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.44
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.43
    Ensembl ID: ENSG00000173575
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.4
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.38
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.37
    Ensembl ID: ENSG00000141522
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.36
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.36
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.35
    Ensembl ID: ENSG00000198898
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.35
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.35
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.34
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.33
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CKS2 (ENSG00000123975)
    Fold Change: 1.33
    Ensembl ID: ENSG00000123975
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.32
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.28
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.27
    Ensembl ID: ENSG00000177556
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.26
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.26
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.24
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.24
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.23
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.21
    Ensembl ID: ENSG00000070961
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.21
    Ensembl ID: ENSG00000134480
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.21
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.21
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.19
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.18
    Ensembl ID: ENSG00000072778
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.17
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.17
    Ensembl ID: ENSG00000172216
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.15
    Ensembl ID: ENSG00000204472
  • Gene Symbol: CKS1B (ENSG00000173207)
    Fold Change: 1.15
    Ensembl ID: ENSG00000173207
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.13
    Ensembl ID: ENSG00000162909
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.13
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.12
    Ensembl ID: ENSG00000149311
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.12
    Ensembl ID: ENSG00000053254
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.11
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.1
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.1
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.1
    Ensembl ID: ENSG00000169442
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142192
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.08
    Ensembl ID: ENSG00000160710
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.07
    Ensembl ID: ENSG00000108561
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.06
    Ensembl ID: ENSG00000155366
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.06
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.05
    Ensembl ID: ENSG00000130303
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.05
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.03
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.03
    Ensembl ID: ENSG00000112576
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.03
    Ensembl ID: ENSG00000107262
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.02
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.01
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.01
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.01
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CASP3 (ENSG00000164305)
    Fold Change: 1.01
    Ensembl ID: ENSG00000164305
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 1
    Ensembl ID: ENSG00000110848
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Cellular origin**: Megakaryocyte progenitor cell is the earliest cytologically identifiable precursor in the thrombocytic series. 2. **Endomitosis**: This cell is capable of endomitosis, a type of cell division that involves the replication of the entire genome without the separation of chromosomes. 3. **Lin-negative**: The megakaryocyte progenitor cell lacks expression of hematopoietic lineage markers (lin-negative). 4. **Differentiation**: This cell differentiates into megakaryocytes, which are responsible for the production of platelets. 5. **Endomitosis**: Megakaryocytes undergo endomitosis to produce megakaryocytes, and eventually, platelets. **Clinical Significance** 1. **Thrombocytopenia**: Megakaryocyte progenitor cell dysfunction or deficiency can lead to thrombocytopenia, a condition characterized by low platelet counts. 2. **Thrombocytosis**: Overproduction of megakaryocytes can lead to thrombocytosis, a condition characterized by high platelet counts. 3. **Platelet disorders**: Megakaryocyte progenitor cell dysfunction or deficiency can lead to various platelet disorders, including thrombocytopenia, thrombocytosis, and platelet function disorders. 4. **Cancer**: Megakaryocyte progenitor cell dysfunction or deficiency has been implicated in various types of cancer, including leukemia and lymphoma. 5. **Regenerative medicine**: Understanding the role of megakaryocyte progenitor cells in platelet production and development can provide insights into regenerative medicine approaches for the treatment of thrombocytopenia and other platelet disorders. **Pathways and Ontology** 1. **Actin cytoskeleton**: Megakaryocyte progenitor cells are involved in the regulation of actin cytoskeleton dynamics. 2. **Adherens junctions**: Megakaryocyte progenitor cells form adherens junctions with other cells, which are essential for platelet production and development. 3. **Apical junction complex**: Megakaryocyte progenitor cells are involved in the formation of apical junction complexes, which are essential for platelet production and development. 4. **Brahma complex**: Megakaryocyte progenitor cells are involved in the regulation of chromatin structure and gene expression through the Brahma complex. 5. **Nucleus**: Megakaryocyte progenitor cells are involved in the regulation of gene expression and cell cycle progression through the nucleus. **Gene Symbol and Ensembl ID** 1. **Gene Symbol**: ACTB 2. **Ensembl ID**: ENSG00000075624 **Pathways and Ontology (B2M)** 1. **Adaptive immune system**: Megakaryocyte progenitor cells are involved in the adaptive immune system. 2. **Amyloid fiber formation**: Megakaryocyte progenitor cells are involved in the formation of amyloid fibers. 3. **Antigen presentation**: Megakaryocyte progenitor cells are involved in the presentation of antigens to T cells. 4. **Cytokine signaling**: Megakaryocyte progenitor cells are involved in cytokine signaling in the immune system. 5. **Disease**: Megakaryocyte progenitor cells are involved in the development of various diseases, including cancer and autoimmune disorders.