Details for: CL0000557

Cell ID: CL0000557

Cell Name: granulocyte monocyte progenitor cell

Marker Score Threshold: 634
(Derived using integrated single-cell and genomic data)

Description: A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.

Synonyms: CFU-C , Colony forming unit in culture, colony forming unit granulocyte macrophage, granulocyte-macrophage progenitor, granulocyte/monocyte precursor, granulocyte/monocyte progenitor, CFU-GM, GMP

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.97
    Ensembl ID: ENSG00000075624
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.8
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.79
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.4
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.39
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AGTR2 (ENSG00000180772)
    Fold Change: 1.38
    Ensembl ID: ENSG00000180772
  • Gene Symbol: ADCYAP1 (ENSG00000141433)
    Fold Change: 1.38
    Ensembl ID: ENSG00000141433
  • Gene Symbol: NR0B1 (ENSG00000169297)
    Fold Change: 1.38
    Ensembl ID: ENSG00000169297
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.38
    Ensembl ID: ENSG00000163286
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.38
    Ensembl ID: ENSG00000111348
  • Gene Symbol: PHOX2A (ENSG00000165462)
    Fold Change: 1.38
    Ensembl ID: ENSG00000165462
  • Gene Symbol: NAT2 (ENSG00000156006)
    Fold Change: 1.38
    Ensembl ID: ENSG00000156006
  • Gene Symbol: ALOX12B (ENSG00000179477)
    Fold Change: 1.38
    Ensembl ID: ENSG00000179477
  • Gene Symbol: ADRB3 (ENSG00000188778)
    Fold Change: 1.38
    Ensembl ID: ENSG00000188778
  • Gene Symbol: AQP2 (ENSG00000167580)
    Fold Change: 1.38
    Ensembl ID: ENSG00000167580
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.38
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ART4 (ENSG00000111339)
    Fold Change: 1.38
    Ensembl ID: ENSG00000111339
  • Gene Symbol: ASMT (ENSG00000196433)
    Fold Change: 1.38
    Ensembl ID: ENSG00000196433
  • Gene Symbol: APLNR (ENSG00000134817)
    Fold Change: 1.37
    Ensembl ID: ENSG00000134817
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: 1.37
    Ensembl ID: ENSG00000110881
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 1.37
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ADORA1 (ENSG00000163485)
    Fold Change: 1.37
    Ensembl ID: ENSG00000163485
  • Gene Symbol: ASCL1 (ENSG00000139352)
    Fold Change: 1.37
    Ensembl ID: ENSG00000139352
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 1.37
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ADRA1B (ENSG00000170214)
    Fold Change: 1.37
    Ensembl ID: ENSG00000170214
  • Gene Symbol: ADRA2A (ENSG00000150594)
    Fold Change: 1.37
    Ensembl ID: ENSG00000150594
  • Gene Symbol: AGTR1 (ENSG00000144891)
    Fold Change: 1.37
    Ensembl ID: ENSG00000144891
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.37
    Ensembl ID: ENSG00000171094
  • Gene Symbol: ANXA13 (ENSG00000104537)
    Fold Change: 1.37
    Ensembl ID: ENSG00000104537
  • Gene Symbol: FASLG (ENSG00000117560)
    Fold Change: 1.37
    Ensembl ID: ENSG00000117560
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 1.37
    Ensembl ID: ENSG00000161798
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 1.37
    Ensembl ID: ENSG00000152092
  • Gene Symbol: ADORA2A (ENSG00000128271)
    Fold Change: 1.37
    Ensembl ID: ENSG00000128271
  • Gene Symbol: ACAN (ENSG00000157766)
    Fold Change: 1.37
    Ensembl ID: ENSG00000157766
  • Gene Symbol: ASPA (ENSG00000108381)
    Fold Change: 1.37
    Ensembl ID: ENSG00000108381
  • Gene Symbol: AQP7 (ENSG00000165269)
    Fold Change: 1.37
    Ensembl ID: ENSG00000165269
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: 1.36
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.36
    Ensembl ID: ENSG00000145362
  • Gene Symbol: APBA1 (ENSG00000107282)
    Fold Change: 1.36
    Ensembl ID: ENSG00000107282
  • Gene Symbol: APLP1 (ENSG00000105290)
    Fold Change: 1.36
    Ensembl ID: ENSG00000105290
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 1.36
    Ensembl ID: ENSG00000196616
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 1.36
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ABCD2 (ENSG00000173208)
    Fold Change: 1.36
    Ensembl ID: ENSG00000173208
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163017
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.35
    Ensembl ID: ENSG00000084234
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.35
    Ensembl ID: ENSG00000189058
  • Gene Symbol: SHROOM2 (ENSG00000146950)
    Fold Change: 1.35
    Ensembl ID: ENSG00000146950
  • Gene Symbol: ALDH1A3 (ENSG00000184254)
    Fold Change: 1.35
    Ensembl ID: ENSG00000184254
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100823
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.34
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.33
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.27
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.25
    Ensembl ID: ENSG00000130402
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.24
    Ensembl ID: ENSG00000204472
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.22
    Ensembl ID: ENSG00000072778
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.22
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.19
    Ensembl ID: ENSG00000128272
  • Gene Symbol: AHCY (ENSG00000101444)
    Fold Change: 1.17
    Ensembl ID: ENSG00000101444
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.17
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.17
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.16
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.15
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.13
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.12
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APOA2 (ENSG00000158874)
    Fold Change: 1.12
    Ensembl ID: ENSG00000158874
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AIRE (ENSG00000160224)
    Fold Change: 1.11
    Ensembl ID: ENSG00000160224
  • Gene Symbol: AMPH (ENSG00000078053)
    Fold Change: 1.11
    Ensembl ID: ENSG00000078053
  • Gene Symbol: AQP9 (ENSG00000103569)
    Fold Change: 1.11
    Ensembl ID: ENSG00000103569
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.11
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ADORA3 (ENSG00000282608)
    Fold Change: 1.11
    Ensembl ID: ENSG00000282608
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ALDH3A1 (ENSG00000108602)
    Fold Change: 1.1
    Ensembl ID: ENSG00000108602
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.09
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.09
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.09
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AFP (ENSG00000081051)
    Fold Change: 1.08
    Ensembl ID: ENSG00000081051
  • Gene Symbol: AMHR2 (ENSG00000135409)
    Fold Change: 1.08
    Ensembl ID: ENSG00000135409
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.08
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: 1.07
    Ensembl ID: ENSG00000167972
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.07
    Ensembl ID: ENSG00000177105
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: 1.06
    Ensembl ID: ENSG00000129673
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.06
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: 1.06
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.05
    Ensembl ID: ENSG00000163631
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.04
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.03
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ADRA2B (ENSG00000274286)
    Fold Change: 1.02
    Ensembl ID: ENSG00000274286
  • Gene Symbol: ADRA2C (ENSG00000184160)
    Fold Change: 1.02
    Ensembl ID: ENSG00000184160
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.02
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.02
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.02
    Ensembl ID: ENSG00000137845
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.01
    Ensembl ID: ENSG00000173020
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATIC (ENSG00000138363)
    Fold Change: 1
    Ensembl ID: ENSG00000138363
Hovered Details

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Hovered Details

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**Key Characteristics** * CD123-positive expression * Lack of Gata1 and Gata2 expression * Expression of C/EBPa and Pu.1 * Can differentiate into granulocytes and monocytes * Can form colonies in culture * Involved in the development of the innate immune system **Clinical Significance** The GMP is an important cell type in the development of various diseases, including: * Leukemia: GMPs can give rise to leukemia cells, particularly acute myeloid leukemia (AML). * Lymphoma: GMPs can also contribute to lymphoma development. * Autoimmune disorders: GMPs can contribute to autoimmune disorders, such as rheumatoid arthritis and lupus. * Infections: GMPs play a crucial role in the development of infections, such as sepsis and pneumonia. * Cancer: GMPs can contribute to cancer development, particularly in the context of bone marrow transplantation. The GMP is also an important cell type in the development of various therapeutic strategies, including: * Bone marrow transplantation: GMPs are used to repopulate the bone marrow in patients with leukemia or other hematological disorders. * Immunotherapy: GMPs can be used to stimulate the immune system in patients with cancer or autoimmune disorders. * Stem cell transplantation: GMPs are used to repopulate the bone marrow in patients with severe combined immunodeficiency (SCID) or other immunodeficiency disorders. Overall, the GMP is an important cell type that plays a crucial role in the development of the innate immune system and various diseases, and has significant implications for the development of therapeutic strategies.