Details for: CL0000558

Cell ID: CL0000558

Cell Name: reticulocyte

Marker Score Threshold: 422
(Derived using integrated single-cell and genomic data)

Description: An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.45
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.21
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.19
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.17
    Ensembl ID: ENSG00000075624
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.16
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.15
    Ensembl ID: ENSG00000169100
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.15
    Ensembl ID: ENSG00000108654
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.09
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.09
    Ensembl ID: ENSG00000149806
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.05
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.04
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.96
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.95
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.9
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 1.88
    Ensembl ID: ENSG00000167658
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 1.87
    Ensembl ID: ENSG00000114942
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.74
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 1.69
    Ensembl ID: ENSG00000074800
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.67
    Ensembl ID: ENSG00000077549
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.67
    Ensembl ID: ENSG00000156976
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.66
    Ensembl ID: ENSG00000164919
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.65
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.61
    Ensembl ID: ENSG00000067560
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.57
    Ensembl ID: ENSG00000067082
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.53
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.53
    Ensembl ID: ENSG00000122545
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.51
    Ensembl ID: ENSG00000120129
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.5
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.48
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.48
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.48
    Ensembl ID: ENSG00000169020
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.48
    Ensembl ID: ENSG00000176340
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.47
    Ensembl ID: ENSG00000051523
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.47
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.47
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.47
    Ensembl ID: ENSG00000143933
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.46
    Ensembl ID: ENSG00000063046
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.46
    Ensembl ID: ENSG00000135940
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.45
    Ensembl ID: ENSG00000154518
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.45
    Ensembl ID: ENSG00000112695
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.45
    Ensembl ID: ENSG00000110321
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.44
    Ensembl ID: ENSG00000179218
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.42
    Ensembl ID: ENSG00000134825
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.4
    Ensembl ID: ENSG00000126267
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.38
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.38
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.37
    Ensembl ID: ENSG00000099624
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.37
    Ensembl ID: ENSG00000111775
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.35
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TSC22D3 (ENSG00000157514)
    Fold Change: 1.35
    Ensembl ID: ENSG00000157514
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.34
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.33
    Ensembl ID: ENSG00000019582
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.31
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ERH (ENSG00000100632)
    Fold Change: 1.3
    Ensembl ID: ENSG00000100632
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.3
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.27
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.27
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.27
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.25
    Ensembl ID: ENSG00000215301
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.25
    Ensembl ID: ENSG00000173674
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.22
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.21
    Ensembl ID: ENSG00000241837
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.2
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.19
    Ensembl ID: ENSG00000182718
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.19
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 1.18
    Ensembl ID: ENSG00000120690
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.18
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.17
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ENSA (ENSG00000143420)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143420
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.16
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.16
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CTSD (ENSG00000117984)
    Fold Change: 1.14
    Ensembl ID: ENSG00000117984
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.1
    Ensembl ID: ENSG00000168036
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.1
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 1.09
    Ensembl ID: ENSG00000171634
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.09
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.09
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196776
  • Gene Symbol: EIF2S3 (ENSG00000130741)
    Fold Change: 1.08
    Ensembl ID: ENSG00000130741
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.08
    Ensembl ID: ENSG00000116459
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.08
    Ensembl ID: ENSG00000128951
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.07
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160014
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.06
    Ensembl ID: ENSG00000100300
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.05
    Ensembl ID: ENSG00000197102
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.04
    Ensembl ID: ENSG00000159199
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.04
    Ensembl ID: ENSG00000129562
  • Gene Symbol: EIF4A1 (ENSG00000161960)
    Fold Change: 1.03
    Ensembl ID: ENSG00000161960
  • Gene Symbol: EWSR1 (ENSG00000182944)
    Fold Change: 1.03
    Ensembl ID: ENSG00000182944
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.03
    Ensembl ID: ENSG00000111348
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.02
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.02
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.01
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.01
    Ensembl ID: ENSG00000123505
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.01
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ECH1 (ENSG00000104823)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104823
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1
    Ensembl ID: ENSG00000146731
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Reticulocyte**: CL0000558 is an immature erythrocyte that undergoes significant changes to mature into a functional red blood cell. 2. **Exosome formation and extrusion**: The cell forms and extrudes exosomes, which remove specific proteins from the plasma membrane. 3. **Protein removal**: The type of protein removed differs between species, but the removal of the transferrin receptor is apparent in mammals and birds. 4. **Gene symbol: B2M**: The gene symbol for this cell is B2M, which is involved in various cellular processes. 5. **Ensembl ID: ENSG00000166710**: The Ensembl ID for this cell is ENSG00000166710, which provides a unique identifier for the cell in the Ensembl database. **Clinical Significance** 1. **Anemia**: CL0000558 is involved in the production of red blood cells, which are essential for transporting oxygen throughout the body. Anemia, a condition characterized by a deficiency in red blood cells, can lead to symptoms such as fatigue, weakness, and shortness of breath. 2. **Iron deficiency**: The cell plays a role in iron ion homeostasis, which is essential for the production of hemoglobin, a protein in red blood cells that carries oxygen. Iron deficiency can lead to anemia and other health problems. 3. **Infectious diseases**: CL0000558 is involved in the adaptive immune system, which is responsible for defending against infectious diseases. The cell's ability to remove specific proteins from the plasma membrane can help to prevent the entry of pathogens into the body. 4. **Cytokine signaling**: The cell is involved in cytokine signaling, which is a critical process in the immune response. Cytokines are signaling molecules that help to coordinate the immune response and promote the production of antibodies. 5. **Disease associations**: CL0000558 has been associated with various diseases, including anemia, iron deficiency, and infectious diseases. The cell's dysfunction can contribute to the development of these diseases, highlighting the importance of understanding its role in cellular processes.