Details for: CL0000559

Cell ID: CL0000559

Cell Name: promonocyte

Marker Score Threshold: 644
(Derived using integrated single-cell and genomic data)

Description: A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.79
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.45
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.19
    Ensembl ID: ENSG00000184009
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.02
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.02
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.86
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.77
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.67
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.66
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.63
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.49
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.44
    Ensembl ID: ENSG00000135404
  • Gene Symbol: AZU1 (ENSG00000172232)
    Fold Change: 2.4
    Ensembl ID: ENSG00000172232
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.39
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.37
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.25
    Ensembl ID: ENSG00000169020
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.25
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.19
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.16
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.15
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.15
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.14
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.13
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.12
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.05
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.98
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.96
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.95
    Ensembl ID: ENSG00000152234
  • Gene Symbol: MS4A3 (ENSG00000149516)
    Fold Change: 1.91
    Ensembl ID: ENSG00000149516
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.86
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.84
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.83
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.83
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.83
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.81
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.79
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.76
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.76
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.73
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.73
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.71
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.71
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.69
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.68
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.67
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.66
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.62
    Ensembl ID: ENSG00000122359
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.61
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.61
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.61
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.61
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.61
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.6
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.56
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.48
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.46
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.46
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.45
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.45
    Ensembl ID: ENSG00000165527
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.44
    Ensembl ID: ENSG00000146731
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.44
    Ensembl ID: ENSG00000108561
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.4
    Ensembl ID: ENSG00000142192
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.39
    Ensembl ID: ENSG00000123505
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.37
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.35
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.35
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.34
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.34
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.33
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.32
    Ensembl ID: ENSG00000138279
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.32
    Ensembl ID: ENSG00000162909
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.32
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.32
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.31
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.27
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.27
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.27
    Ensembl ID: ENSG00000087274
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.25
    Ensembl ID: ENSG00000183255
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.25
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.21
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.19
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.16
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.16
    Ensembl ID: ENSG00000197894
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.16
    Ensembl ID: ENSG00000143799
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.1
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.1
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.1
    Ensembl ID: ENSG00000197043
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.09
    Ensembl ID: ENSG00000104765
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.08
    Ensembl ID: ENSG00000004455
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142599
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.05
    Ensembl ID: ENSG00000149823
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.04
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.03
    Ensembl ID: ENSG00000128595
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 1.02
    Ensembl ID: ENSG00000136250
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.02
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1
    Ensembl ID: ENSG00000174437
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics:** 1. **CD11b positivity**: Promonocytes express CD11b, a surface molecule involved in cell adhesion and immune responses. 2. **Fine azurophil granules**: Promonocytes contain azurophil granules, which are involved in the storage and release of antimicrobial peptides and enzymes. 3. **Actin cytoskeleton regulation**: Promonocytes regulate the actin cytoskeleton, which is essential for cell motility, phagocytosis, and cell signaling. 4. **Cell-cell junction organization**: Promonocytes are involved in the organization of cell-cell junctions, which are critical for tissue structure and immune responses. 5. **Immune responses**: Promonocytes participate in immune responses by producing cytokines, chemokines, and other immune-related molecules. **Clinical Significance:** 1. **Infectious diseases**: Promonocytes are involved in the immune response to infections, including bacterial, viral, and parasitic infections. 2. **Autoimmune disorders**: Promonocytes can contribute to autoimmune disorders, such as rheumatoid arthritis and lupus, by promoting inflammation and tissue damage. 3. **Cancer**: Promonocytes can be involved in the development and progression of various cancers, including leukemia and lymphoma, by promoting tumor growth and metastasis. 4. **Immunodeficiency disorders**: Promonocytes can be impaired in immunodeficiency disorders, such as HIV/AIDS, leading to increased susceptibility to infections. 5. **Regenerative medicine**: Promonocytes have the potential to be used as a source of stem cells for regenerative medicine, particularly for tissue repair and replacement. **Pathways/Ontology:** Promonocytes are involved in various cellular processes, including: 1. **Actin cytoskeleton regulation**: Promonocytes regulate the actin cytoskeleton, which is essential for cell motility, phagocytosis, and cell signaling. 2. **Cell-cell junction organization**: Promonocytes are involved in the organization of cell-cell junctions, which are critical for tissue structure and immune responses. 3. **Immune responses**: Promonocytes participate in immune responses by producing cytokines, chemokines, and other immune-related molecules. 4. **Apoptosis**: Promonocytes can regulate apoptosis, or programmed cell death, which is essential for tissue homeostasis and immune responses. 5. **DNA damage repair**: Promonocytes can participate in DNA damage repair, which is critical for maintaining genome stability and preventing cancer. Overall, promonocytes play a crucial role in the immune system and are involved in various cellular processes, including actin cytoskeleton regulation, cell-cell junction organization, and immune responses. Their dysregulation can contribute to various diseases, including infectious diseases, autoimmune disorders, and cancers.