Details for: CL0000573

Cell ID: CL0000573

Cell Name: retinal cone cell

Marker Score Threshold: 2870
(Derived using integrated single-cell and genomic data)

Description: One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.

Synonyms: cone

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CRYAA (ENSG00000160202)
    Fold Change: 4.02
    Ensembl ID: ENSG00000160202
  • Gene Symbol: CDK3 (ENSG00000250506)
    Fold Change: 3.96
    Ensembl ID: ENSG00000250506
  • Gene Symbol: CD5 (ENSG00000110448)
    Fold Change: 3.95
    Ensembl ID: ENSG00000110448
  • Gene Symbol: CNGA4 (ENSG00000132259)
    Fold Change: 3.94
    Ensembl ID: ENSG00000132259
  • Gene Symbol: DRD3 (ENSG00000151577)
    Fold Change: 3.94
    Ensembl ID: ENSG00000151577
  • Gene Symbol: COL19A1 (ENSG00000082293)
    Fold Change: 3.93
    Ensembl ID: ENSG00000082293
  • Gene Symbol: CHRM5 (ENSG00000184984)
    Fold Change: 3.93
    Ensembl ID: ENSG00000184984
  • Gene Symbol: RUNX2 (ENSG00000124813)
    Fold Change: 3.9
    Ensembl ID: ENSG00000124813
  • Gene Symbol: CFTR (ENSG00000001626)
    Fold Change: 3.9
    Ensembl ID: ENSG00000001626
  • Gene Symbol: C9 (ENSG00000113600)
    Fold Change: 3.88
    Ensembl ID: ENSG00000113600
  • Gene Symbol: CPB2 (ENSG00000080618)
    Fold Change: 3.87
    Ensembl ID: ENSG00000080618
  • Gene Symbol: ALOX12 (ENSG00000108839)
    Fold Change: 3.85
    Ensembl ID: ENSG00000108839
  • Gene Symbol: CLC (ENSG00000105205)
    Fold Change: 3.85
    Ensembl ID: ENSG00000105205
  • Gene Symbol: CR1L (ENSG00000197721)
    Fold Change: 3.83
    Ensembl ID: ENSG00000197721
  • Gene Symbol: C6 (ENSG00000039537)
    Fold Change: 3.53
    Ensembl ID: ENSG00000039537
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 3.53
    Ensembl ID: ENSG00000091138
  • Gene Symbol: ATP12A (ENSG00000075673)
    Fold Change: 3.52
    Ensembl ID: ENSG00000075673
  • Gene Symbol: CPA2 (ENSG00000158516)
    Fold Change: 3.51
    Ensembl ID: ENSG00000158516
  • Gene Symbol: CAV3 (ENSG00000182533)
    Fold Change: 3.5
    Ensembl ID: ENSG00000182533
  • Gene Symbol: CKM (ENSG00000104879)
    Fold Change: 3.38
    Ensembl ID: ENSG00000104879
  • Gene Symbol: BHMT (ENSG00000145692)
    Fold Change: 3.35
    Ensembl ID: ENSG00000145692
  • Gene Symbol: CD6 (ENSG00000013725)
    Fold Change: 3.3
    Ensembl ID: ENSG00000013725
  • Gene Symbol: BMX (ENSG00000102010)
    Fold Change: 3.24
    Ensembl ID: ENSG00000102010
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 3.21
    Ensembl ID: ENSG00000136250
  • Gene Symbol: CRYBA1 (ENSG00000108255)
    Fold Change: 3.19
    Ensembl ID: ENSG00000108255
  • Gene Symbol: CYP3A7 (ENSG00000160870)
    Fold Change: 3.18
    Ensembl ID: ENSG00000160870
  • Gene Symbol: CCR3 (ENSG00000183625)
    Fold Change: 3.12
    Ensembl ID: ENSG00000183625
  • Gene Symbol: CRHR1 (ENSG00000120088)
    Fold Change: 2.94
    Ensembl ID: ENSG00000120088
  • Gene Symbol: AMBN (ENSG00000178522)
    Fold Change: 2.91
    Ensembl ID: ENSG00000178522
  • Gene Symbol: CASP10 (ENSG00000003400)
    Fold Change: 2.81
    Ensembl ID: ENSG00000003400
  • Gene Symbol: CDH4 (ENSG00000179242)
    Fold Change: 2.75
    Ensembl ID: ENSG00000179242
  • Gene Symbol: DCC (ENSG00000187323)
    Fold Change: 2.69
    Ensembl ID: ENSG00000187323
  • Gene Symbol: ARG1 (ENSG00000118520)
    Fold Change: 2.65
    Ensembl ID: ENSG00000118520
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 2.65
    Ensembl ID: ENSG00000188641
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.63
    Ensembl ID: ENSG00000140945
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 2.62
    Ensembl ID: ENSG00000198821
  • Gene Symbol: COL10A1 (ENSG00000123500)
    Fold Change: 2.6
    Ensembl ID: ENSG00000123500
  • Gene Symbol: ALX3 (ENSG00000156150)
    Fold Change: 2.57
    Ensembl ID: ENSG00000156150
  • Gene Symbol: CD4 (ENSG00000010610)
    Fold Change: 2.55
    Ensembl ID: ENSG00000010610
  • Gene Symbol: CXCR5 (ENSG00000160683)
    Fold Change: 2.5
    Ensembl ID: ENSG00000160683
  • Gene Symbol: CCR6 (ENSG00000112486)
    Fold Change: 2.46
    Ensembl ID: ENSG00000112486
  • Gene Symbol: ASIP (ENSG00000101440)
    Fold Change: 2.39
    Ensembl ID: ENSG00000101440
  • Gene Symbol: C2 (ENSG00000166278)
    Fold Change: 2.37
    Ensembl ID: ENSG00000166278
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 2.37
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ARSD (ENSG00000006756)
    Fold Change: 2.36
    Ensembl ID: ENSG00000006756
  • Gene Symbol: CENPA (ENSG00000115163)
    Fold Change: 2.31
    Ensembl ID: ENSG00000115163
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: 2.31
    Ensembl ID: ENSG00000155897
  • Gene Symbol: BLK (ENSG00000136573)
    Fold Change: 2.27
    Ensembl ID: ENSG00000136573
  • Gene Symbol: CEL (ENSG00000170835)
    Fold Change: 2.21
    Ensembl ID: ENSG00000170835
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 2.11
    Ensembl ID: ENSG00000012779
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.03
    Ensembl ID: ENSG00000165092
  • Gene Symbol: CACNG1 (ENSG00000108878)
    Fold Change: 2
    Ensembl ID: ENSG00000108878
  • Gene Symbol: CHRNA7 (ENSG00000175344)
    Fold Change: 1.99
    Ensembl ID: ENSG00000175344
  • Gene Symbol: CDH8 (ENSG00000150394)
    Fold Change: 1.9
    Ensembl ID: ENSG00000150394
  • Gene Symbol: CLDN4 (ENSG00000189143)
    Fold Change: 1.88
    Ensembl ID: ENSG00000189143
  • Gene Symbol: DOCK1 (ENSG00000150760)
    Fold Change: 1.83
    Ensembl ID: ENSG00000150760
  • Gene Symbol: AQP9 (ENSG00000103569)
    Fold Change: 1.8
    Ensembl ID: ENSG00000103569
  • Gene Symbol: CYP3A4 (ENSG00000160868)
    Fold Change: 1.79
    Ensembl ID: ENSG00000160868
  • Gene Symbol: BRDT (ENSG00000137948)
    Fold Change: 1.7
    Ensembl ID: ENSG00000137948
  • Gene Symbol: CDC25C (ENSG00000158402)
    Fold Change: 1.63
    Ensembl ID: ENSG00000158402
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.54
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.54
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.51
    Ensembl ID: ENSG00000170017
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.48
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CHRM2 (ENSG00000181072)
    Fold Change: 1.46
    Ensembl ID: ENSG00000181072
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.37
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ADORA2B (ENSG00000170425)
    Fold Change: 1.36
    Ensembl ID: ENSG00000170425
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 1.29
    Ensembl ID: ENSG00000108654
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 1.29
    Ensembl ID: ENSG00000131143
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 1.28
    Ensembl ID: ENSG00000127184
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.27
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.27
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.23
    Ensembl ID: ENSG00000099622
  • Gene Symbol: DOCK2 (ENSG00000134516)
    Fold Change: 1.22
    Ensembl ID: ENSG00000134516
  • Gene Symbol: DNAH8 (ENSG00000124721)
    Fold Change: 1.19
    Ensembl ID: ENSG00000124721
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.19
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.18
    Ensembl ID: ENSG00000135390
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.17
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.16
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.16
    Ensembl ID: ENSG00000126267
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.16
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.15
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.13
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.13
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.11
    Ensembl ID: ENSG00000135404
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.1
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CACNA1E (ENSG00000198216)
    Fold Change: 1.07
    Ensembl ID: ENSG00000198216
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143761
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.06
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.05
    Ensembl ID: ENSG00000179218
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.04
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CPN1 (ENSG00000120054)
    Fold Change: 1.03
    Ensembl ID: ENSG00000120054
  • Gene Symbol: CHI3L2 (ENSG00000064886)
    Fold Change: 1.03
    Ensembl ID: ENSG00000064886
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.02
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.02
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.01
    Ensembl ID: ENSG00000101439
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.01
    Ensembl ID: ENSG00000005022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.01
    Ensembl ID: ENSG00000134825
Hovered Details

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Hovered Details

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**Key Characteristics** * **Photoreceptor cells**: Retinal cone cells are one of the two types of photoreceptor cells in the vertebrate retina. * **Color vision**: Cones are responsible for color vision and high spatial and temporal acuity. * **Photopigments**: Cones contain photopigments in invaginations of the cell membrane of the outer segment. * **Less sensitive to light**: Cones are less sensitive to light compared to rods. * **Gene encoding**: Cones are encoded by several genes, including CRYAA, CDK3, CD5, CNGA4, DRD3, COL19A1, CHRM5, and RUNX2. * **Cellular processes**: Cones are involved in various cellular processes such as visual perception, cell recognition, and development. **Clinical Significance** * **Color vision deficiency**: Cone cells are responsible for color vision, and defects in these cells can lead to color vision deficiency, also known as color blindness. * **Retinitis pigmentosa**: Cone cells are affected in retinitis pigmentosa, a genetic disorder that causes progressive vision loss. * **Age-related macular degeneration**: Cone cells are affected in age-related macular degeneration, a condition that causes vision loss in older adults. * **Genetic disorders**: Cone cells are encoded by several genes, and mutations in these genes can lead to genetic disorders such as Leber congenital amaurosis and retinitis pigmentosa. * **Visual perception**: Cones play a critical role in visual perception, and defects in these cells can affect visual acuity and color perception. In conclusion, retinal cone cells are essential for color vision and high spatial and temporal acuity, and defects in these cells can lead to various visual disorders. Understanding the characteristics and clinical significance of cone cells is crucial for the diagnosis and treatment of visual disorders.