Cell ID: CL0000583

Cell Name: alveolar macrophage

CSI Thresholds:

Select	Context	Threshold
	Overall	8.8107
	Lymphangioleiomyomatosis	225.7374
	Lung + Lymphangioleiomyomatosis	225.6896
	Non-specific interstitial pneumonia	160.3554
	Lung + Non-specific interstitial pneumonia	160.3465
	Lung parenchyma + Healthy	94.6416
	Lung + Chronic obstructive pulmonary disease	94.0826
	Lung parenchyma	93.1396
	Chronic obstructive pulmonary disease	81.4305
	Alveolus of lung	79.3143
	Lung + Hypersensitivity pneumonitis	76.6059
	Hypersensitivity pneumonitis	76.5336
	Lung + Lung adenocarcinoma	73.2067
	Alveolus of lung + Pulmonary emphysema	73.1628
	Pulmonary emphysema	73.0447
	Lung + Healthy	71.8047
	Alveolus of lung + Healthy	70.9268
	Pleural effusion + Lung adenocarcinoma	69.1355
	Pleural effusion	57.3735
	Interstitial lung disease	57.0920
	Lung + Interstitial lung disease	57.0650
	Omentum	48.6154
	Pulmonary sarcoidosis	42.2250
	Lung + Pulmonary sarcoidosis	42.2092
	Pulmonary fibrosis	41.5333
	Lung + Pulmonary fibrosis	41.5193
	Caecum + Healthy	39.8134
	Lung adenocarcinoma	39.1704
	Squamous cell lung carcinoma	37.9916
	Lung + Squamous cell lung carcinoma	37.9562
	Non-small cell lung carcinoma	35.8977
	Lung + Non-small cell lung carcinoma	35.8543
	Upper lobe of left lung	35.3548
	Upper lobe of left lung + Healthy	35.3535
	Ileum + Healthy	34.2644
	Lung + Pneumonia	33.9477
	Pneumonia	33.9325
	Transverse colon	30.7981
	Blood	30.1760
	Ileum	29.6528
	Transverse colon + Healthy	24.6952
	Thoracic lymph node + Healthy	24.2977
	Thoracic lymph node	24.2647
	Bone marrow + Healthy	24.1584
	Lingula of left lung	22.6428
	Lingula of left lung + Healthy	22.5235
	Lymph node	21.6562
	Lymph node + Lung adenocarcinoma	19.4365
	Respiratory airway + Healthy	18.6805
	Respiratory airway	18.5802
	Mesenteric lymph node + Healthy	18.0197
	Mesenteric lymph node	18.0175
	Lamina propria + Healthy	17.9743
	Lamina propria	17.9636
	Brain + Lung adenocarcinoma	17.7236
	Lower lobe of left lung + Healthy	15.0362
	Lower lobe of left lung	15.0295
	Jejunal epithelium + Healthy	13.2926
	Omentum + Healthy	13.2032
	Jejunal epithelium	12.9310
	Blood + Healthy	12.4705
	Liver + Healthy	11.6587
	Healthy	11.4784
	Duodenum	10.5300
	Lung + COVID-19	10.4078
	Duodenum + Healthy	9.4861
	Skeletal muscle tissue + Healthy	9.3979
	Skeletal muscle tissue	9.3272
	Spleen	9.0221
	Spleen + Healthy	9.0093
	Brain	8.9528
	Bone marrow	8.8900
	Lung	8.6636
	Liver	8.5479
	COVID-19	8.3689
	Caecum	7.9683
	Lung + Pleomorphic carcinoma	7.6918
	Pleomorphic carcinoma	7.6442
	Lung + Lung large cell carcinoma	5.8739
	Lung large cell carcinoma	5.8568
	Nose + Healthy	4.9441
	Nose	3.5099
	Bronchus	2.5299
	Bronchus + Healthy	2.4739
	Trachea + Healthy	2.4717
	Trachea	1.9671
	Chronic rhinitis	1.8440
	Nose + Chronic rhinitis	1.7190
	Sigmoid colon + Healthy	-0.7992
	Sigmoid colon	-5.1639

Select

(Cell Significance Index is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers.)

Description: A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative.

Synonyms: dust cell, MF.Lu