Details for: CL0000583

Cell ID: CL0000583

Cell Name: alveolar macrophage

Marker Score Threshold: 25611
(Derived using integrated single-cell and genomic data)

Description: A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative.

Synonyms: dust cell, MF.Lu

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 3.05
    Ensembl ID: ENSG00000130208
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.03
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.01
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 2.97
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 2.95
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.9
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.88
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.87
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.86
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.86
    Ensembl ID: ENSG00000135046
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 2.86
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.85
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.82
    Ensembl ID: ENSG00000117410
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.82
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.81
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.78
    Ensembl ID: ENSG00000149925
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 2.77
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.72
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.71
    Ensembl ID: ENSG00000169100
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 2.71
    Ensembl ID: ENSG00000147872
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.64
    Ensembl ID: ENSG00000084234
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.61
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.56
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.54
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.54
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.46
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 2.44
    Ensembl ID: ENSG00000140379
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 2.43
    Ensembl ID: ENSG00000012779
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 2.4
    Ensembl ID: ENSG00000071553
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.39
    Ensembl ID: ENSG00000143878
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 2.36
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.35
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.32
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.3
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.28
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.25
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.25
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 2.18
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.16
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.16
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 2.08
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.07
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 2.06
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 2.06
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.04
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 2
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 2
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.97
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.96
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.96
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 1.93
    Ensembl ID: ENSG00000143153
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.89
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.88
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.86
    Ensembl ID: ENSG00000196975
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.81
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.8
    Ensembl ID: ENSG00000072778
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.78
    Ensembl ID: ENSG00000165272
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.76
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.72
    Ensembl ID: ENSG00000072110
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.69
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.67
    Ensembl ID: ENSG00000138279
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.62
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.58
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.57
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.57
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.56
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.54
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.49
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.49
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.39
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.39
    Ensembl ID: ENSG00000114573
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.38
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.37
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.36
    Ensembl ID: ENSG00000162772
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.34
    Ensembl ID: ENSG00000156273
  • Gene Symbol: AGRP (ENSG00000159723)
    Fold Change: 1.32
    Ensembl ID: ENSG00000159723
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.32
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.31
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.31
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.31
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ALAS1 (ENSG00000023330)
    Fold Change: 1.25
    Ensembl ID: ENSG00000023330
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.24
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.22
    Ensembl ID: ENSG00000075239
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.2
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.19
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.15
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.12
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.11
    Ensembl ID: ENSG00000143149
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 1.07
    Ensembl ID: ENSG00000109321
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.07
    Ensembl ID: ENSG00000004059
  • Gene Symbol: PARP4 (ENSG00000102699)
    Fold Change: 1.07
    Ensembl ID: ENSG00000102699
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.07
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.06
    Ensembl ID: ENSG00000072210
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.06
    Ensembl ID: ENSG00000174437
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.03
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.03
    Ensembl ID: ENSG00000155097
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.03
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 1.02
    Ensembl ID: ENSG00000139567
Hovered Details

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Hovered Details

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**Key Characteristics** * Tissue-resident macrophage found in the alveoli of the lungs * Ingests small inhaled particles and degrades them * Presents antigens to immunocompetent cells * Characterized by expression of specific markers, including: + F4/80 + CD11b + CD11c + CD68 + Sialoadhesin + Dectin-1 + MR * Involved in regulation of cholesterol efflux and metabolism * Interacts with other immune cells, such as T cells and dendritic cells **Clinical Significance** The alveolar macrophage plays a critical role in the innate immune response and has been implicated in various diseases, including: * Asthma: Alveolar macrophages are involved in the regulation of airway inflammation and hyperresponsiveness. * Chronic obstructive pulmonary disease (COPD): Alveolar macrophages are involved in the regulation of airway inflammation and clearance of inhaled particles. * Lung cancer: Alveolar macrophages have been shown to interact with cancer cells and contribute to the development of lung cancer. * Pulmonary fibrosis: Alveolar macrophages are involved in the regulation of fibrosis and scarring in the lungs. * COVID-19: Alveolar macrophages have been shown to interact with SARS-CoV-2 and contribute to the development of COVID-19. The alveolar macrophage is also involved in the regulation of cholesterol efflux and metabolism, and has been shown to interact with other immune cells, such as T cells and dendritic cells. This highlights the importance of the alveolar macrophage in the regulation of the immune response and the development of diseases. **Pathways and Ontology** The alveolar macrophage is involved in various pathways and ontologies, including: * Cholesterol efflux and metabolism * Antigen presentation and processing * Innate immune response * Adaptive immune response * Cytokine signaling * Cell signaling * Protein binding and homodimerization * Gene expression and transcription * Chromatin organization and remodeling These pathways and ontologies highlight the complex role of the alveolar macrophage in the regulation of the immune response and the development of diseases.