Details for: CL0000584

Cell ID: CL0000584

Cell Name: enterocyte

Marker Score Threshold: 4799
(Derived using integrated single-cell and genomic data)

Description: An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen.

Synonyms: differentiated enterocyte, mature enterocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.44
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.4
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.38
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.37
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.09
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 3.09
    Ensembl ID: ENSG00000166825
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.08
    Ensembl ID: ENSG00000169100
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.07
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.04
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 3.01
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.98
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.91
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.86
    Ensembl ID: ENSG00000143153
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: 2.85
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.8
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.79
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.75
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2.72
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.71
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 2.66
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.55
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.55
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.51
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.5
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.49
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.48
    Ensembl ID: ENSG00000111275
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.4
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.39
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: 2.38
    Ensembl ID: ENSG00000122971
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 2.37
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.33
    Ensembl ID: ENSG00000143761
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.33
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.29
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASL (ENSG00000126522)
    Fold Change: 2.12
    Ensembl ID: ENSG00000126522
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.12
    Ensembl ID: ENSG00000141522
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.11
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 2.1
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 2.08
    Ensembl ID: ENSG00000130707
  • Gene Symbol: APOA1 (ENSG00000118137)
    Fold Change: 2.05
    Ensembl ID: ENSG00000118137
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.05
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 2.01
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.98
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.9
    Ensembl ID: ENSG00000165092
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.9
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.89
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.86
    Ensembl ID: ENSG00000004455
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: 1.83
    Ensembl ID: ENSG00000161533
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.82
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.8
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.79
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 1.79
    Ensembl ID: ENSG00000110245
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.78
    Ensembl ID: ENSG00000142192
  • Gene Symbol: APOA4 (ENSG00000110244)
    Fold Change: 1.72
    Ensembl ID: ENSG00000110244
  • Gene Symbol: APOB (ENSG00000084674)
    Fold Change: 1.68
    Ensembl ID: ENSG00000084674
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.66
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.66
    Ensembl ID: ENSG00000197894
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.66
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.64
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ALDOB (ENSG00000136872)
    Fold Change: 1.63
    Ensembl ID: ENSG00000136872
  • Gene Symbol: ADH1C (ENSG00000248144)
    Fold Change: 1.59
    Ensembl ID: ENSG00000248144
  • Gene Symbol: AADAC (ENSG00000114771)
    Fold Change: 1.58
    Ensembl ID: ENSG00000114771
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.53
    Ensembl ID: ENSG00000148700
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.45
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.45
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.45
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA13 (ENSG00000104537)
    Fold Change: 1.44
    Ensembl ID: ENSG00000104537
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.43
    Ensembl ID: ENSG00000072210
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.4
    Ensembl ID: ENSG00000127837
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.37
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.36
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.35
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.32
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.29
    Ensembl ID: ENSG00000004059
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.24
    Ensembl ID: ENSG00000115963
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.24
    Ensembl ID: ENSG00000151729
  • Gene Symbol: ANG (ENSG00000214274)
    Fold Change: 1.23
    Ensembl ID: ENSG00000214274
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.23
    Ensembl ID: ENSG00000134287
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.19
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.18
    Ensembl ID: ENSG00000023445
  • Gene Symbol: APEH (ENSG00000164062)
    Fold Change: 1.18
    Ensembl ID: ENSG00000164062
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.18
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.17
    Ensembl ID: ENSG00000143149
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.16
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.16
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.14
    Ensembl ID: ENSG00000204574
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.14
    Ensembl ID: ENSG00000177105
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.12
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.1
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.1
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.1
    Ensembl ID: ENSG00000095139
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.09
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.08
    Ensembl ID: ENSG00000198363
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.08
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.07
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CRYBG1 (ENSG00000112297)
    Fold Change: 1.06
    Ensembl ID: ENSG00000112297
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.01
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.01
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 1.01
    Ensembl ID: ENSG00000122729
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1
    Ensembl ID: ENSG00000110330
Hovered Details

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Hovered Details

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**Key Characteristics** * **Epithelial cell**: Enterocytes are a type of epithelial cell that lines the small intestine. * **Microvilli**: The apical plasma membrane of enterocytes is folded into microvilli, increasing the surface area for nutrient absorption. * **Actin cytoskeleton**: The actin cytoskeleton plays a crucial role in maintaining cell shape, cell motility, and intracellular transport. * **Adherens junctions**: Adherens junctions are involved in cell-cell adhesion and the maintenance of tissue structure. * **Apical protein localization**: The localization of proteins to the apical surface of enterocytes is crucial for nutrient absorption and cellular function. **Clinical Significance** * **Nutrient absorption**: Enterocytes play a critical role in the absorption of nutrients from the intestinal lumen, which is essential for maintaining proper nutrition and overall health. * **Gastrointestinal disorders**: Alterations in enterocyte function or structure can lead to various gastrointestinal disorders, such as malabsorption syndromes, inflammatory bowel disease, and cancer. * **Infectious diseases**: Enterocytes can be involved in the pathogenesis of infectious diseases, such as Leishmania phagocytosis, which is a type of parasitic infection. * **Cancer**: Abnormalities in enterocyte function or structure have been implicated in the development of certain types of cancer, such as colorectal cancer. **Relationships with Other Genes and Pathways** * **Gene symbol ACTB**: The gene symbol ACTB is associated with various cellular processes, including actin cytoskeleton dynamics, adherens junction assembly, and apical protein localization. * **Pathways involved**: The pathways involved in enterocyte function include actin cytoskeleton dynamics, adherens junction assembly, apical protein localization, and membrane trafficking. * **Interactions with other genes**: Enterocytes interact with other genes and pathways, including those involved in nutrient absorption, cell-cell adhesion, and intracellular transport. **Regulation of Gene Expression** * **Positive regulation**: The expression of genes involved in enterocyte function is positively regulated by various signaling pathways, including those involved in nutrient absorption and cell-cell adhesion. * **Negative regulation**: The expression of genes involved in enterocyte function is also negatively regulated by various signaling pathways, including those involved in cell motility and intracellular transport. **Clinical Implications** * **Disease diagnosis**: The study of enterocyte function and structure can provide insights into the diagnosis and treatment of various gastrointestinal disorders. * **Therapeutic targeting**: The identification of specific genes and pathways involved in enterocyte function can provide targets for therapeutic intervention in diseases such as malabsorption syndromes and inflammatory bowel disease. * **Nutritional interventions**: The study of enterocyte function and structure can provide insights into the development of nutritional interventions to improve nutrient absorption and overall health.