Details for: CL0000595

Cell ID: CL0000595

Cell Name: enucleate erythrocyte

Marker Score Threshold: 394
(Derived using integrated single-cell and genomic data)

Description: An erythrocyte lacking a nucleus.

Synonyms: red blood cell, RBC

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.75
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.62
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.62
    Ensembl ID: ENSG00000156508
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.42
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.38
    Ensembl ID: ENSG00000172757
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.36
    Ensembl ID: ENSG00000169100
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.36
    Ensembl ID: ENSG00000127184
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.35
    Ensembl ID: ENSG00000167658
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.33
    Ensembl ID: ENSG00000108654
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.31
    Ensembl ID: ENSG00000104529
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.31
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.24
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.13
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.12
    Ensembl ID: ENSG00000135390
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.07
    Ensembl ID: ENSG00000114942
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.07
    Ensembl ID: ENSG00000164919
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.01
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2
    Ensembl ID: ENSG00000124172
  • Gene Symbol: EIF4A2 (ENSG00000156976)
    Fold Change: 1.98
    Ensembl ID: ENSG00000156976
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.94
    Ensembl ID: ENSG00000126267
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 1.92
    Ensembl ID: ENSG00000112695
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.89
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.86
    Ensembl ID: ENSG00000135940
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.85
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.8
    Ensembl ID: ENSG00000135404
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.77
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.75
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.74
    Ensembl ID: ENSG00000179218
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.74
    Ensembl ID: ENSG00000110321
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 1.73
    Ensembl ID: ENSG00000120129
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.73
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.71
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.64
    Ensembl ID: ENSG00000154723
  • Gene Symbol: EIF4B (ENSG00000063046)
    Fold Change: 1.63
    Ensembl ID: ENSG00000063046
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.63
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.6
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.58
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.58
    Ensembl ID: ENSG00000213719
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.58
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.57
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.57
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.57
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 1.55
    Ensembl ID: ENSG00000051523
  • Gene Symbol: DBI (ENSG00000155368)
    Fold Change: 1.53
    Ensembl ID: ENSG00000155368
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.52
    Ensembl ID: ENSG00000110955
  • Gene Symbol: COX7B (ENSG00000131174)
    Fold Change: 1.51
    Ensembl ID: ENSG00000131174
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.49
    Ensembl ID: ENSG00000160213
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.46
    Ensembl ID: ENSG00000152234
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.45
    Ensembl ID: ENSG00000127022
  • Gene Symbol: DAD1 (ENSG00000129562)
    Fold Change: 1.43
    Ensembl ID: ENSG00000129562
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.42
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.41
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.4
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.38
    Ensembl ID: ENSG00000128272
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.38
    Ensembl ID: ENSG00000198931
  • Gene Symbol: DDX3X (ENSG00000215301)
    Fold Change: 1.38
    Ensembl ID: ENSG00000215301
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.36
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.36
    Ensembl ID: ENSG00000085224
  • Gene Symbol: EIF1AX (ENSG00000173674)
    Fold Change: 1.31
    Ensembl ID: ENSG00000173674
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.28
    Ensembl ID: ENSG00000160014
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.27
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.26
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.26
    Ensembl ID: ENSG00000161203
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.24
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.23
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.23
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.21
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 1.21
    Ensembl ID: ENSG00000113712
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.21
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.2
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 1.18
    Ensembl ID: ENSG00000101439
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.18
    Ensembl ID: ENSG00000182718
  • Gene Symbol: EIF2S3 (ENSG00000130741)
    Fold Change: 1.18
    Ensembl ID: ENSG00000130741
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.17
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.17
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.16
    Ensembl ID: ENSG00000172270
  • Gene Symbol: DUT (ENSG00000128951)
    Fold Change: 1.13
    Ensembl ID: ENSG00000128951
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.13
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.13
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CTNNB1 (ENSG00000168036)
    Fold Change: 1.12
    Ensembl ID: ENSG00000168036
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.12
    Ensembl ID: ENSG00000042753
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.12
    Ensembl ID: ENSG00000108561
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.11
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.1
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.1
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.09
    Ensembl ID: ENSG00000146731
  • Gene Symbol: DYNC1H1 (ENSG00000197102)
    Fold Change: 1.09
    Ensembl ID: ENSG00000197102
  • Gene Symbol: EIF4A1 (ENSG00000161960)
    Fold Change: 1.09
    Ensembl ID: ENSG00000161960
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.08
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.07
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ECH1 (ENSG00000104823)
    Fold Change: 1.07
    Ensembl ID: ENSG00000104823
  • Gene Symbol: DDT (ENSG00000099977)
    Fold Change: 1.06
    Ensembl ID: ENSG00000099977
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.04
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CYC1 (ENSG00000179091)
    Fold Change: 1.03
    Ensembl ID: ENSG00000179091
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.02
    Ensembl ID: ENSG00000110651
  • Gene Symbol: DDX6 (ENSG00000110367)
    Fold Change: 1.01
    Ensembl ID: ENSG00000110367
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.01
    Ensembl ID: ENSG00000115307
Hovered Details

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Hovered Details

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**Key Characteristics** The enucleate erythrocyte has several key characteristics that enable it to perform its primary function: 1. **Anucleate structure**: The enucleate erythrocyte lacks a nucleus, which allows it to maintain a fluid environment and avoid the constraints of a nucleus. 2. **Biconcave disk shape**: The enucleate erythrocyte's biconcave disk shape allows it to navigate through narrow blood vessels and increase its surface area for gas exchange. 3. **Unique gene expression profile**: The enucleate erythrocyte has a distinct gene expression profile that includes genes involved in cell signaling, adhesion, and cytoskeletal organization. 4. **Actin cytoskeleton**: The enucleate erythrocyte has a dynamic actin cytoskeleton that plays a crucial role in cell shape, movement, and function. 5. **Adherens junctions**: The enucleate erythrocyte has adherens junctions that help maintain its shape and prevent cell-cell adhesion. **Clinical Significance** The enucleate erythrocyte plays a crucial role in maintaining the circulatory system, and its dysfunction can lead to various clinical conditions, including: 1. **Anemia**: A decrease in the number of enucleate erythrocytes can lead to anemia, a condition characterized by a decrease in red blood cell mass. 2. **Sickle cell disease**: A mutation in the HBB gene can lead to sickle cell disease, a condition characterized by an abnormal enucleate erythrocyte shape that can cause vaso-occlusion. 3. **Thalassemia**: A mutation in the HBA1 or HBB genes can lead to thalassemia, a condition characterized by a decrease in enucleate erythrocyte production. 4. **Leukemia**: The enucleate erythrocyte can be involved in leukemia, a type of cancer that affects the blood and bone marrow. In conclusion, the enucleate erythrocyte is a unique cell type that plays a crucial role in the circulatory system. Its dysfunction can lead to various clinical conditions, and understanding its biology is essential for the diagnosis and treatment of these conditions.