Details for: CL0000644

Cell ID: CL0000644

Cell Name: Bergmann glial cell

Marker Score Threshold: 408
(Derived using integrated single-cell and genomic data)

Description: Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses.

Synonyms: Bergmann astrocyte, Bergmann glial cell of cerebellum

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.1
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.42
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.02
    Ensembl ID: ENSG00000198668
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.67
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.62
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.56
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.41
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.32
    Ensembl ID: ENSG00000185650
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.29
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.27
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.25
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.25
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.25
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.19
    Ensembl ID: ENSG00000154723
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.19
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.11
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.09
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.08
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.01
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.99
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.99
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.98
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.97
    Ensembl ID: ENSG00000149925
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.93
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.88
    Ensembl ID: ENSG00000117410
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.85
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.82
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.8
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.76
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.75
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.73
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.71
    Ensembl ID: ENSG00000116459
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.69
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.67
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.65
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.57
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.55
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.55
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.51
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.5
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.5
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104763
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.49
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.49
    Ensembl ID: ENSG00000182718
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.48
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.46
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.44
    Ensembl ID: ENSG00000138279
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.44
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.4
    Ensembl ID: ENSG00000159199
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.4
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.37
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.34
    Ensembl ID: ENSG00000148700
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.34
    Ensembl ID: ENSG00000189058
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 1.34
    Ensembl ID: ENSG00000171885
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 1.33
    Ensembl ID: ENSG00000129244
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.32
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.31
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.31
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.29
    Ensembl ID: ENSG00000163399
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.28
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.27
    Ensembl ID: ENSG00000145362
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.27
    Ensembl ID: ENSG00000142192
  • Gene Symbol: MPPED1 (ENSG00000186732)
    Fold Change: 1.27
    Ensembl ID: ENSG00000186732
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.25
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1.25
    Ensembl ID: ENSG00000018625
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: 1.23
    Ensembl ID: ENSG00000196136
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.22
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: 1.19
    Ensembl ID: ENSG00000117054
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.19
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.18
    Ensembl ID: ENSG00000197894
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.18
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 1.18
    Ensembl ID: ENSG00000135298
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.17
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.14
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.13
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.13
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.13
    Ensembl ID: ENSG00000060971
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.12
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110330
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177556
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.1
    Ensembl ID: ENSG00000004455
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.1
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.09
    Ensembl ID: ENSG00000196975
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.07
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.07
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.06
    Ensembl ID: ENSG00000087088
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.06
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.05
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.04
    Ensembl ID: ENSG00000128595
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.04
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ASNS (ENSG00000070669)
    Fold Change: 1.02
    Ensembl ID: ENSG00000070669
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.02
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.02
    Ensembl ID: ENSG00000035687
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.01
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.01
    Ensembl ID: ENSG00000174437
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1
    Ensembl ID: ENSG00000101966
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** * **Location**: BGCs are found in the cerebellar cortex, specifically in the Purkinje cell layer. * **Structure**: BGCs have a radial morphology, with their cell bodies located in the Purkinje cell layer and processes extending into the molecular layer. * **Function**: BGCs play a crucial role in the development and maintenance of the cerebellum, particularly in the early stages of cerebellar formation. * **Expression of glutamate transporters**: BGCs express high densities of glutamate transporters, which limit the diffusion of glutamate during its release from synaptic terminals. * **Participation in synapse formation and pruning**: BGCs participate in the pruning or addition of synapses in the cerebellum. **Clinical Significance** Bergmann glial cells have been implicated in various neurological disorders, including: * **Cerebellar ataxia**: BGCs have been shown to be involved in the development of cerebellar ataxia, a condition characterized by impaired coordination and balance. * **Cerebral ischemia**: BGCs have been shown to play a role in the pathogenesis of cerebral ischemia, a condition characterized by reduced blood flow to the brain. * **Neurodegenerative diseases**: BGCs have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In addition, BGCs have been shown to have potential therapeutic applications in the treatment of neurological disorders, including: * **Glial cell transplantation**: BGCs have been shown to be a potential source of cells for transplantation in the treatment of neurological disorders. * **Gene therapy**: BGCs have been shown to be a potential target for gene therapy in the treatment of neurological disorders. * **Stem cell therapy**: BGCs have been shown to be a potential source of stem cells for the treatment of neurological disorders. Overall, Bergmann glial cells are an important component of the cerebellum and play a crucial role in the development and maintenance of the cerebellum. Further research is needed to fully understand the role of BGCs in neurological disorders and to explore their potential therapeutic applications.